Results 51 to 60 of about 66,858 (295)

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Unveiling the alkyne-π interaction using metal-organic cage compounds

Communications Chemistry
Alkynes play a crucial role in chemical synthesis, bio-imaging, and drug design. Despite their significance, the intermolecular interactions involving alkynes have been largely unexplored.
Junrui Liu, Shujun Ning, Ting Chen, Zi-Ang Nan, Zhe-Ning Chen, Luyao Liu, Zhu Zhuo, Qing Li, Wei Wang, Lu Zhang, You-Gui Huang   +10 more
doaj   +1 more source

Regio- and Stereoselective Allylindation of Alkynes Using InBr3 and Allylic Silanes: Synthesis, Characterization, and Application of 1,4-Dienylindiums toward Skipped Dienes

Molecules, 2018
Regioselective anti-allylindation of alkynes was achieved using InBr3 and allylic silanes. Various types of alkynes and allylic silanes were applicable to the present allylindation.
Yoshihiro Nishimoto, Junyi Yi, Tatsuaki Takata, Akio Baba, Makoto Yasuda   +4 more
doaj   +1 more source

Decarboxylative Hydroalkylation of Alkynes [PDF]

Journal of the American Chemical Society, 2018
The merger of open- and closed-shell elementary organometallic steps has enabled the selective intermolecular addition of nucleophilic radicals to unactivated alkynes. A range of carboxylic acids can be subjected to a CO2 extrusion, nickel capture, migratory insertion sequence with terminal and internal alkynes to generate stereodefined functionalized ...
Nicholas A. Till, Russell T. Smith, David W. C. MacMillan   +2 more
openaire   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

X-H Bond Insertion Promoted by Heterogeneous Dirhodium Metal–Organic Cage with Alkynes as Safe Carbene Precursors

Molecules, 2023
A facile and efficient methodology for the generation of the C-X (X = Si, B) bond through a carbene insertion process was demonstrated using a dirhodium metal–organic cage, MOC-Rh-1, as a heterogeneous catalyst.
Lianfen Chen, Chaoyi Zhao, Weixian Mo, Chunsheng Li, Xiaoming Lin   +4 more
doaj   +1 more source

Intermolecular Hydroaminoalkylation of Alkynes

Chemistry – A European Journal, 2021
AbstractIntermolecular hydroaminoalkylation reactions of alkynes with secondary amines, which selectively give access to allylic amines with E configuration of the alkene unit, are achieved in the presence of titanium catalysts. Successful reactions of symmetrically substituted diaryl‐ and dialkylalkynes as well as a terminal alkyne take place with N ...
Tobias Kaper, Malte Fischer, Hermann Thye, Dennis Geik, Marc Schmidtmann, Ruediger Beckhaus, Sven Doye   +6 more
openaire   +2 more sources

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Crystal structure and Hirshfeld surface analysis of N-(tert-butyl)-2-(phenylethynyl)imidazo[1,2-a]pyridin-3-amine

Acta Crystallographica Section E: Crystallographic Communications, 2019
The bicyclic imidazo[1,2-a]pyridine core of the title compound, C19H19N3, is relatively planar with an r.m.s. deviation of 0.040 Å. The phenyl ring is inclined to the mean plane of the imidazo[1,2-a]pyridine unit by 18.2 (1)°.
Zahira Tber, Sevgi Kansiz, Mohamed El Hafi, Mohamed Loubidi, Jabrane Jouha, Necmi Dege, El Mokhtar Essassi, Joel T. Mague   +7 more
doaj   +1 more source

Alkyne-Tagged PLGA Allows Direct Visualization of Nanoparticles In Vitro and Ex Vivo by Stimulated Raman Scattering Microscopy

, 2019
Polymeric nanoparticles (NPs) are attractive candidates for the controlled and targeted delivery of therapeutics in vitro and in vivo. However, detailed understanding of the uptake, location, and ultimate cellular fate of the NPs is necessary to satisfy ...
Martin Lee (4786263), Anna Williams (124124), Valerie G. Brunton (7325402), Stefan A. Cairns, Lida Zoupi, Sally Vanden-Hehir, Michael P. Shaver, Martin Lee, Alison N. Hulme (1336164), Anna Williams, Sally Vanden-Hehir (7325393), Valerie G. Brunton, Alison N. Hulme, Lida Zoupi (7325399), Stefan A. Cairns (7325396), Michael P. Shaver (1569409)   +15 more
core   +1 more source