Results 81 to 90 of about 255,027 (296)

The Importance of HLA Assessment in “Off-the-Shelf” Allogeneic Mesenchymal Stem Cells Based-Therapies

International Journal of Molecular Sciences, 2019
The need for more effective therapies of chronic and acute diseases has led to the attempts of developing more adequate and less invasive treatment methods. Regenerative medicine relies mainly on the therapeutic potential of stem cells.
M. Kot, M. Baj-Krzyworzeka, R. Szatanek, Aleksandra Musiał-Wysocka, Magdalena Suda-Szczurek, M. Majka   +5 more
semanticscholar   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

The Role of Anti-Thymocyte Globulin or Alemtuzumab-Based Serotherapy in the Prophylaxis and Management of Graft-Versus-Host Disease

Biomedicines, 2017
Allogeneic hematopoietic stem cell transplant is an established treatment modality for hematologic and non-hematologic diseases. However, it is associated with acute and long-term sequelae which can translate into mortality.
Robert Ali, Jeremy Ramdial, Sandra Algaze, Amer Beitinjaneh   +3 more
doaj   +1 more source

Understanding bio‐based polymers: A study of origins, properties, biodegradation and their impact on health and the environment

FEBS Open Bio, EarlyView.
This review provides an overview of bio‐based polymer sources, their unique functional properties and their environmental impact, and addresses their role as sustainable alternatives. It discusses end‐of‐life options, including composting and anaerobic digestion for renewable energy.
Sabina Kolbl Repinc, Blaž Stres, Mirica Karlovits, Igor Karlovits, Petra Jerič, Ondrej Panák, Anja Verbič, Blaž Likozar, Uroš Novak   +8 more
wiley   +1 more source

Corrigendum: Phase I trial outcome of amnion cell therapy in patients with ischemic stroke (I-ACT)

Frontiers in Neuroscience, 2023
Thanh G. Phan, Thanh G. Phan, Rebecca Lim, Rebecca Lim, Mirja Krause, Mirja Krause, Siow T. Chan, Siow T. Chan, Hannah McDonald, Hannah McDonald, Poh-Yi Gan, Poh-Yi Gan, Shenpeng R. Zhang, Liz J. Barreto Arce, Jason Vuong, Jason Vuong, Tharani Thirugnanachandran, Tharani Thirugnanachandran, Benjamin Clissold, Benjamin Clissold, John Ly, John Ly, Shaloo Singhal, Shaloo Singhal, Marie Veronic Hervet, Marie Veronic Hervet, Hyun Ah Kim, Grant R. Drummond, Euan M. Wallace, Euan M. Wallace, Henry Ma, Henry Ma, Christopher G. Sobey   +32 more
doaj   +1 more source

Dissecting Allo-Sensitization After Local Administration of Human Allogeneic Adipose Mesenchymal Stem Cells in Perianal Fistulas of Crohn's Disease Patients

Frontiers in Immunology, 2019
Adipose mesenchymal stem cells (ASC) are considered minimally immunogenic. This is due to the low expression of human leukocyte antigens I (HLA-I), lack of HLA-II expression and low expression of co-stimulatory molecules such as CD40 and CD80.
Alvaro Avivar-Valderas, Cristina Martín-Martín, Cristina Ramírez, Borja Del Río, Ramón Menta, Pablo Mancheño-Corvo, Maitane Ortiz-Virumbrales, Ángel Herrero-Méndez, Julián Panés, Damián García-Olmo, José Luís Castañer, Itziar Palacios, Eleuterio Lombardo, Wilfried Dalemans, Olga DelaRosa   +14 more
doaj   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Genetically modified CD7-targeting allogeneic CAR-T cell therapy with enhanced efficacy for relapsed/refractory CD7-positive hematological malignancies: a phase I clinical study

Cell Research, 2022
Yong-xian Hu, Yali Zhou, Mingming Zhang, Houli Zhao, G. Wei, Wengang Ge, Q. Cui, Qi-tian Mu, Gong Chen, Luwei Han, Tingting Guo, Jiazhen Cui, Xiaoyan Jiang, Xiujun Zheng, Shuhui Yu, Xiaolong Li, Xingwang Zhang, Mingxi Chen, Xiujuan Li, M. Gao, Kangyan Wang, Cheng Zu, Hao Zhang, Xiao-peng He, Yanbin Wang, Dongrui Wang, Jiangtao Ren, He Huang   +27 more
semanticscholar   +1 more source

Local immunomodulation with Fas ligand-engineered biomaterials achieves allogeneic islet graft acceptance

Nature Materials, 2018
Islet transplantation is a promising therapy for type 1 diabetes. However, chronic immunosuppression to control rejection of allogeneic islets induces morbidities and impairs islet function.
Devon Headen, K. Woodward, María M. Coronel, P. Shrestha, J. Weaver, Hong Zhao, Min Tan, Michael D. Hunckler, W. Bowen, Christopher T. Johnson, L. Shea, E. Yolcu, Andrés J. García, H. Shirwan   +13 more
semanticscholar   +1 more source