Novel receptor targets for production and action of allopregnanolone in the central nervous system: a focus on pregnane xenobiotic receptor [PDF]
Frontiers in Cellular Neuroscience, 2014 Neurosteroids are cholesterol-based hormones that can be produced in the brain, independent of secretion from peripheral endocrine glands, such as the gonads and adrenals.
Cheryl A Frye +2 more
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Effect of progesterone administration in male and female smokers on nicotine withdrawal and neural response to smoking cues: role of progesterone conversion to allopregnanolone [PDF]
Biology of Sex Differences, 2022 Highlights Progesterone has sex-dependent effects on smoking measures in individuals with Tobacco Use Disorder. Higher conversion of progesterone to allopregnanolone (as indicated by the allopregnanolone:progesterone ratio) was associated with lower ...
Andrew M. Novick +10 more
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Allopregnanolone reinstates tyrosine hydroxylase immunoreactive neurons and motor performance in an MPTP-lesioned mouse model of Parkinson's disease. [PDF]
PLoS ONE, 2012 Restorative/protective therapies to restore dopamine neurons in the substantia nigra pars compacta (SNpc) are greatly needed to effectively change the debilitating course of Parkinson's disease.
Samuel O Adeosun +17 more
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The Role of Allopregnanolone in Pregnancy in Predicting Postpartum Anxiety Symptoms [PDF]
Frontiers in Psychology, 2019 Postpartum depression is a serious illness affecting up to 15% of women worldwide after childbirth, and our understanding of its biology is limited. Postpartum anxiety is perhaps more prevalent and less understood.
Lauren M. Osborne +6 more
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Allopregnanolone relieves paclitaxel induced mechanical hypersensitivity via inhibiting spinal cord PGE2-EP2 mediated microglia-neuron signaling [PDF]
IBRO Neuroscience ReportsChemotherapy-induced neuropathic pain (CINP) is a serious adverse effect of commonly used chemotherapeutics. Neurosteroid allopregnanolone is suggested to modulate the expression of various receptors or enzymes that involved in pain perception ...
Kunlin Guo +5 more
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Age and sex effects of a validated LC-MS/MS method for the simultaneous quantification of testosterone, allopregnanolone, and its isomers in human serum [PDF]
Scientific ReportsDespite the great relevance of the neurosteroid allopregnanolone and related isomers to various health conditions, quantification typically involves immunoassay, which suffers from serious issues with cross-reactivity of closely related molecules.
Khalisa Amir Hamzah +6 more
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Allopregnanolone-induced rise in intracellular calcium in embryonic hippocampal neurons parallels their proliferative potential [PDF]
, 2008 Background Factors that regulate intracellular calcium concentration are known to play a critical role in brain function and neural development, including neural plasticity and neurogenesis.
Jun Ming Wang, Roberta Dı́az Brinton
openalex +5 more sources
Interactions of L-3,5,3'-Triiodothyronine, Allopregnanolone, and Ivermectin with the GABAA Receptor: Evidence for Overlapping Intersubunit Binding Modes [PDF]
, 2015 Structural mechanisms of modulation of γ-aminobutyric acid (GABA) type A receptors by neurosteroids and hormones remain unclear. The thyroid hormone L-3,5,3'-triiodothyronine (T3) inhibits GABAA receptors at micromolar concentrations and has common ...
Thomas Westergard +3 more
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Allopregnanolone Decreases Evoked Dopamine Release Differently in Rats by Sex and Estrous Stage
Frontiers in Pharmacology, 2021 Mesolimbic dopamine transmission is dysregulated in multiple psychiatric disorders, including addiction. Previous studies found that the endogenous GABAergic steroid (3α,5α)-3-hydroxy-5-pregnan-20-one (allopregnanolone) modulates dopamine levels in the ...
Ana Paula S. Dornellas +12 more
doaj +1 more source
Modulating fatty acid signaling to restore allopregnanolone balance: a novel strategy for anxiety disorders [PDF]
Signal Transduct Target TherBi Z, Xie Y, Han N, Hua Z, Zhuang H.
europepmc +2 more sources