Results 91 to 100 of about 12,622 (280)

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

High basal serum allopregnanolone levels in overweight girls [PDF]

International Journal of Obesity, 2006
Several studies demonstrated that obese subjects have a hyperactive hypothalamic-pituitary-adrenal axis and that sex steroid hormones have been closely related to the regulation of adiposity, either through direct or indirect physiological mechanisms. Allopregnanolone (3alpha-hydroxy-5alpha-pregn-20-one; AP) is a circulating neuroactive steroid hormone
PREDIERI, Barbara, Luisi S, Casarosa E, De Simone M, BALLI, Fiorella, Bernasconi S, Rossi M, Petraglia F, IUGHETTI, Lorenzo   +8 more
openaire   +4 more sources

Status epilepticus: Updates on mechanisms and treatments

Epilepsia Open, EarlyView.
Abstract Status epilepticus (SE) consists of prolonged, self‐sustaining seizures and is a common neurological emergency that causes respiratory compromise and neuronal injury. Without prompt treatment, the seizures can become resistant to benzodiazepines, leading to the progressive evolution of established, refractory, and super‐refractory SE.
Suchitra Joshi, Jaideep Kapur
wiley   +1 more source

Progesterone and Allopregnanolone Rapidly Attenuate Estrogen-Associated Mechanical Allodynia in Rats with Persistent Temporomandibular Joint Inflammation

Frontiers in Integrative Neuroscience, 2020
Temporomandibular joint disorder (TMD) is associated with pain in the joint (temporomandibular joint, TMJ) and muscles involved in mastication. TMD pain dissipates following menopause but returns in some women undergoing estrogen replacement therapy ...
Rebecca S Hornung, W. Benton, S. Tongkhuya, L. Uphouse, P. Kramer, D. Averitt   +5 more
semanticscholar   +1 more source

Peak visual gamma frequency is modified across the healthy menstrual cycle [PDF]

, 2018
Fluctuations in gonadal hormones over the course of the menstrual cycle are known to cause functional brain changes and are thought to modulate changes in the balance of cortical excitation and inhibition.
McMilllan, Rebecca L., Muthukumaraswamy, Suresh D., Shaw, Alexander D., Singh, Krish D., Sumner, Rachael L., Sundram, Fred   +5 more
core   +2 more sources

Psychosocial and menstrual correlates of premenstrual disorders: A community‐based study

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective To assess the background, psychosocial, and menstrual factors associated with premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD) in a community‐based cohort. Methods A prospective cohort study was conducted using data from users of a menstrual tracking application.
Shiori Itoi, Makiko Sampei, Takayuki Tatsumi, Yutaka Osuga, Kaori Koga, Satoshi Narumi, Naho Morisaki   +6 more
wiley   +1 more source

FIGO best practice recommendations for the mental health of women at menopausal age

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Mental health during the menopausal transition requires focused attention to ensure supportive experiences for women. This review presents the International Federation of Gynecology and Obstetrics (FIGO) recommendations and summarizes the evidence, addressing 13 key questions framed by members of the FIGO Committee on Women at Menopausal Age ...
Suvarna Khadilkar, Hema Divakar, Chiara Benedetto, Andrea Genazzani, Diana Ramos, Elizabete Argale, Gandhali Deshpande, Martha Hicky, Agnaldo Lopes Da Silva Filho, Enrique Herrera, Milan Balkrishnan   +10 more
wiley   +1 more source

Divergent Transcriptomic Effects of Allopregnanolone in Postpartum Depression

Genes, 2023
Brexanolone, a formulation of the neurosteroid allopregnanolone (ALLO), is approved for treating postpartum depression (PPD) and is being investigated for therapeutic efficacy across numerous neuropsychiatric disorders. Given ALLO’s beneficial effects on mood in women with PPD compared to healthy control women, we sought to characterize and compare the
Rudzinskas, Sarah A., Mazzu, Maria A., Schiller, Crystal Edler, Meltzer-Brody, Samantha, Rubinow, David R., Schmidt, Peter J., Goldman, David   +6 more
openaire   +2 more sources

Neurosteroid involvement in threatened preterm labour

Endocrinology, Diabetes & Metabolism, 2021
Introduction The neurosteroid allopregnanolone modulates oxytocin expression in the brain, and its effects arise from its action on the GABAA receptor. Whether neurosteroid levels and the function of the GABAA receptor are involved in the risk of preterm
Sahruh Turkmen, Torbjörn Bäckström, Yvonne Kangas Flodin, Marie Bixo   +3 more
doaj   +1 more source

Gabrb2 knock-out mice exhibit double-directed PMDD-like symptoms: GABAAR subunits, neurotransmitter metabolism disruption, and allopregnanolone binding [PDF]

, 2022
Mingzhou Gao, Hao Zhang, Ya Sun, Zhan Gao, Chunyan Sun, Fengqin Wei, Dongmei Gao   +6 more
openalex   +1 more source