Results 121 to 130 of about 12,622 (280)

Assessment of neuroactive steroids in cerebrospinal fluid comparing acute relapse and stable disease in relapsing-remitting multiple sclerosis [PDF]

, 2016
Previous studies have reported an involvement of neuroactive steroids as neuroprotective and anti-inflammatory agents in neurological disorders such as multiple sclerosis (MS); an analysis of their profile during a specific clinical phase of MS is ...
Bues, B., CALIGNANO, ANTONIO, Carotenuto, A., Cerillo, I., Mangone, G., OREFICE, GIUSEPPE, OREFICE, NICOLA SALVATORE, Rehm, R., SACCA', FRANCESCO   +8 more
core   +1 more source

Mechanisms of spinal glial activation in chemotherapy‐induced peripheral neuropathy: Focus on microglia and astrocytes

Ibrain, Volume 12, Issue 1, Page 65-85, Spring 2026.
Chemotherapy‐induced peripheral neuropathy (CIPN) remains a major clinical challenge, with central sensitization considered an important pathological mechanism in its occurrence and persistence. This review focuses on spinal astrocytes and microglia, systematically summarizing the pathological mechanisms of spinal glial cells involved in CIPN caused by
Long Gu, Song Cao, Yonghuai Feng
wiley   +1 more source

Pediatric super‐refractory status epilepticus treated with allopregnanolone [PDF]

Annals of Neurology, 2014
Super‐refractory status epilepticus is a life‐threatening condition. Resistance to benzodiazepine and barbiturate treatment for this disorder is thought to be due to internalization of synaptic γ‐aminobutyric acid (GABA)Areceptors, and withdrawal of benzodiazepines and barbiturates during treatment often triggers seizure recurrence.
Broomall, Eileen, Natale, JoAnne E, Grimason, Michele, Goldstein, Joshua, Smith, Craig M, Chang, Celia, Kanes, Stephen, Rogawski, Michael A, Wainwright, Mark S   +8 more
openaire   +4 more sources

Safety and efficacy of zuranolone in Japanese adults with major depressive disorder: An open‐label, repeated‐treatment part of a Phase 3 clinical trial

Psychiatry and Clinical Neurosciences Reports, Volume 5, Issue 1, March 2026.
Abstract Aim To evaluate the safety and tolerability of repeating 14‐day treatment with zuranolone (30 mg) followed by a 6‐week follow‐up period (one treatment cycle) for a maximum of six treatment cycles in Japanese participants with major depressive disorder. Methods This multicenter Phase 3 study was conducted in two parts (70 sites; Japan).
Masaki Kato, Kazuyuki Nakagome, Takamichi Baba, Takuhiro Sonoyama, Hiroki Fukuju, Ryosuke Shimizu, Juan Carlos Gomez, Tomoko Motomiya, Takeshi Inoue   +8 more
wiley   +1 more source

Allopregnanolone and progesterone in relation to a single electroconvulsive therapy seizure and subsequent clinical outcome: an observational cohort study

BMC Psychiatry
Background Electroconvulsive therapy (ECT) is an important treatment for several severe psychiatric conditions, yet its precise mechanism of action remains unknown.
Elin Thörnblom, Janet L. Cunningham, Malin Gingnell, Mikael Landén, Jonas Bergquist, Robert Bodén   +5 more
doaj   +1 more source

Analysis of depressive symptom trajectory patterns with zuranolone: Time‐series clustering of Japanese Phase 2 and Phase 3 trial data

Psychiatry and Clinical Neurosciences Reports, Volume 5, Issue 1, March 2026.
In this pooled analysis of Phase 2/3 trials in Japanese adults with major depressive disorder (MDD), we aimed to characterize depressive symptom trajectories following zuranolone 30 mg administration. Dynamic Time Warping–based k‐means clustering identified four distinct symptom trajectories.
Masaki Kato, Takamichi Baba, Saki Nakano, Yuto Kashiwagi, Tomoko Motomiya, Nakao Iwata   +5 more
wiley   +1 more source

Identification of compounds with anti-convulsant properties in a zebrafish model of epileptic seizures [PDF]

, 2012
The availability of animal models of epileptic seizures provides opportunities to identify novel anticonvulsants for the treatment of people with epilepsy.
Anandahan, Baraban, Baraban, Baraban, Berghmans, Bozzi, Buchholtz, Cachat, Cachat, Chang, Colman, Coyne, Cramer, Darland, Dhir, Feldman, Greenberg, Greer, Heilig, Hortopan, Hortopan, Hosie, Huang, Kaminski, Kokel, Lin, Lipsky, Loebrich, Luszczki, Löscher, Mahé, Mishra, Nalivaeva, Norton, Pack, Picazo, Reddy, Reddy, Reid, Remy, Sarang, Seeman, Stafstrom, Steenbergen, Stewart, Thisse, Thorsell, Tian, Tochman, Tutka, Vale, Von Hofsten, Wallenstein, Winter, Zhang   +54 more
core   +2 more sources

Neurosteroids as novel antidepressants and anxiolytics: GABA-A receptors and beyond

Neurobiology of Stress, 2019
The recent FDA approval of the neurosteroid, brexanolone (allopregnanolone), as a treatment for women with postpartum depression, and successful trials of a related neuroactive steroid, SGE-217, for men and women with major depressive disorder offer the ...
Charles F. Zorumski, Steven M. Paul, Douglas F. Covey, Steven Mennerick   +3 more
doaj   +1 more source

The Sooner, the Better: Neuroprotective Strategies in Fetuses With Congenital Heart Disease

Prenatal Diagnosis, Volume 46, Issue 3, Page 368-381, March 2026.
ABSTRACT Congenital heart disease (CHD) is the most frequent congenital malformation at birth and is associated with neurodevelopmental impairments. Alterations in cardiovascular physiology can lead to reduced cerebral blood perfusion and oxygenation, which negatively affects brain growth and maturation.
Maaike Nijman, Mirthe E. M. van der Meijden, Johannes M. P. J. Breur, Raymond Stegeman, Nicolaas J. G. Jansen, Mireille N. Bekker, Manon J. N. L. Benders, Nathalie H. P. Claessens   +7 more
wiley   +1 more source

Finasteride withdrawal induces anxiety‐like behavior and novelty avoidance in adult male rats

Journal of Neuroendocrinology, Volume 38, Issue 3, March 2026.
Abstract Finasteride, an inhibitor of the enzyme 5alpha‐reductase, prescribed for benign prostatic hyperplasia and androgenetic alopecia, induces a wide variety of side effects during treatment and upon withdrawal, like sexual dysfunction and cognitive and psychological disorders, inducing the so‐called post‐finasteride syndrome (PFS).
Lucia Cioffi, Silvia Diviccaro, Gabriela Chrostek, Francesco Paolo Ulloa Severino, Silvia Giatti, Diego Scheggia, Roberto Cosimo Melcangi   +6 more
wiley   +1 more source