Results 181 to 190 of about 6,010 (206)
Some of the next articles are maybe not open access.
Reinforcing effects of the neurosteroid allopregnanolone in rats
Pharmacology Biochemistry and Behavior, 2002The GABA(A) receptor positive modulator allopregnanolone (3alpha-hydroxy-5alpha-pregnan-20-one) is a potent neurosteroid with behavioral and biochemical characteristics similar to ethanol, barbiturates, and benzodiazepines. This suggests that neurosteroids may provide an alternative class of sedative/hypnotic, anticonvulsant, and anxiolytic ...
Rachna S, Sinnott +2 more
openaire +2 more sources
Anticonvulsant action of allopregnanolone in immature rats
Epilepsy Research, 2006Anticonvulsant activity of allopregnanolone, a neurosteroid allosterically modulating GABA(A) receptor was tested in a model of motor seizures elicited by pentetrazol in immature rats. Rats 7, 12, 18, 25 or 90 days old were pretreated with allopregnanolone in doses from 5 to 40 mg/kg i.p.
P, Mares +3 more
openaire +2 more sources
Physiological markers of rapid antidepressant effects of allopregnanolone
Journal of Neuroendocrinology, 2021Abstract The rise of ketamine and brexanolone as rapid antidepressant treatments raises the question of common mechanisms. Both drugs act without the long onset time of traditional antidepressants such as selective serotonin reuptake inhibitors.
Peter M. Lambert +3 more
openaire +2 more sources
Olanzapine increases allopregnanolone in the rat cerebral cortex
Biological Psychiatry, 2000The neurosteroid allopregnanolone (3alpha-hydroxy-5alpha-pregnan-20-one) has anxiolytic and anticonvulsant properties, potentiating GABA(A) receptor chloride channel function with 20-fold higher potency than benzodiazepines. Behavioral studies demonstrate that olanzapine has anxiolyticlike properties in animals, but the mechanism responsible for these ...
Christine E Marx +2 more
exaly +3 more sources
Multifunctional aspects of allopregnanolone in stress and related disorders
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2014Allopregnanolone (3α-hydroxy-5α-pregnan-20-one) is a major cholesterol-derived neurosteroid in the central nervous system and is synthesized from progesterone by steroidogenic enzymes, 5α-reductase (the rate-limiting enzyme) and 3α-hydroxysteroid dehydrogenase.
Anjana, Bali, Amteshwar Singh, Jaggi
openaire +2 more sources
Allopregnanolone and pregnanolone are produced by the human corpus luteum
Molecular and Cellular Endocrinology, 2005Using a dispersed human luteal cell culture model, progesterone, allopregnanolone and pregnanolone release following treatment by incremental doses of human chorionic gonadotrophin (hCG) were evaluated. Corpus luteum tissues, obtained from 48 healthy women scheduled for benign surgery, were grouped according to luteal age and tissue concentration of ...
Ulrika, Ottander +5 more
openaire +2 more sources
On the anticonvulsant effect of allopregnanolone (a neurosteroid) in neonatal rats
Life Sciences, 2015Allopregnanolone has shown potent anticonvulsant activity in the adult brain. However, none of the studies have shown its effect in neonatal animal models of seizures. The current study explored the effect of allopregnanolone in animal models of neonatal status epilepticus.Allopregnanolone was administered 10min before administration of kainic acid or ...
Ashish, Dhir, Kanwaljit, Chopra
openaire +2 more sources
Levels of Testosterone, Allopregnanolone and Homocysteine in Severe Hypothyroidism
Clinical Chemistry and Laboratory Medicine, 2002Hypothyroidism is very often associated with cardiovascular diseases and neurological complications. Recently, homocysteine has been studied as an independent risk factor for atherosclerosis which negatively affects vascular endothelial cells. Because homocysteine metabolism is related to thyroid and steroid hormones, we studied these relationships in ...
Marie, Bicíková +5 more
openaire +2 more sources
Progesterone metabolite allopregnanolone in women with premenstrual syndrome
Obstetrics & Gynecology, 1997To evaluate the anxiolytic 3alpha-5alpha-reduced progesterone metabolite allopregnanolone in the luteal phase of the menstrual cycle in women with premenstrual syndrome (PMS) and controls.Thirty-five women with prospectively documented PMS and 36 controls were evaluated.
A J, Rapkin +5 more
openaire +2 more sources
Aggressive behavior as a reinforcer in mice: activation by allopregnanolone
Psychopharmacology, 2002The neurobiological mechanisms that underlie the motivation to engage in an aggressive confrontation remain to be investigated.The objective was to develop a method to differentiate pharmacologically the performance elements of aggressive behavior from behaviors that precede an aggressive encounter.Male CFW mice were housed as "residents" and trained ...
Eric W, Fish +2 more
openaire +2 more sources