Results 11 to 20 of about 12,622 (280)
Allopregnanolone in Postpartum Depression
Frontiers in Global Women's Health, 2022 Postpartum depression (PPD) is a debilitating psychiatric disorder characterized by a high worldwide prevalence and serious long-term negative outcomes for both mothers and children.
G. Pinna, F. B. Almeida, John M. Davis
semanticscholar +4 more sources
Allopregnanolone: An overview on its synthesis and effects [PDF]
Journal of Neuroendocrinology, 2021 Allopregnanolone, a 3α,5α‐progesterone metabolite, acts as a potent allosteric modulator of the γ‐aminobutyric acid type A receptor. In the present review, the synthesis of this neuroactive steroid occurring in the nervous system is discussed with ...
S. Diviccaro +4 more
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Allopregnanolone: From molecular pathophysiology to therapeutics. A historical perspective
Neurobiology of Stress, 2020 Allopregnanolone is synthesized in the central nervous system either de novo from cholesterol or from steroid hormone precursors like progesterone and pregnenolone. Over the past 30 years, direct and rapid, non-genomic actions of allopregnanolone and its
Steven M Paul +2 more
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Allopregnanolone: Regenerative therapeutic to restore neurological health
Neurobiology of Stress, 2022 Chronic stress has been proposed as a driver of altered brain structure and function, including the pathogenesis of neurodegenerative diseases and a driver of disease progression.
Gerson D. Hernandez, R. Brinton
semanticscholar +4 more sources
Biomolecules, 2023 Background: Allopregnanolone is one of the most studied neuroactive steroids; yet, despite its relevance to neuropsychiatric research, it is not known how it, as well as its ratio to progesterone, varies across all six subphases of the menstrual cycle ...
Ajna Hamidovic +4 more
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Allopregnanolone in mood disorders: mechanism and therapeutic development.
Pharmacological Research, 2021 The neuroactive steroid allopregnanolone (ALLO) is an endogenous positive allosteric modulator of GABA type A receptor (GABAAR), and the down-regulation of its biosynthesis have been attributed to the development of mood disorders, such as depression ...
Shiyi Chen, Lijuan Gao, Xiaoyu Li, Y. Ye
semanticscholar +3 more sources
The role of allopregnanolone in depressive-like behaviors: Focus on neurotrophic proteins
Neurobiology of Stress, 2020 Allopregnanolone (3α,5α-tetrahydroprogesterone; pharmaceutical formulation: brexanolone) is a neurosteroid that has recently been approved for the treatment of postpartum depression, promising to fill part of a long-lasting gap in the effectiveness of ...
Felipe Borges Almeida +2 more
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The Allopregnanolone Response to Acute Stress in Females: Preclinical and Clinical Studies
Biomolecules, 2022 The neuroactive steroid allopregnanolone ((3α,5α)-3-hydroxypregnan-20-one or 3α,5α-THP) plays a key role in the response to stress, by normalizing hypothalamic-pituitary-adrenal (HPA) axis function to restore homeostasis. Most studies have been conducted
Maria Giuseppina Pisu +4 more
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Biosynthesis and biological action of pineal allopregnanolone [PDF]
Frontiers in Cellular Neuroscience, 2014 The pineal gland transduces photoperiodic changes to the neuroendocrine system by rhythmic secretion of melatonin. We recently provided new evidence that the pineal gland is a major neurosteroidogenic organ and actively produces a variety of ...
Kazuyoshi eTsutsui, Shogo eHaraguchi
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Pleiotropic actions of allopregnanolone underlie therapeutic benefits in stress-related disease
Neurobiology of Stress, 2020 For several years, research from around the world has suggested that the neuroactive steroid (3α,5α)-3-hydroxypregnan-20-one (allopregnanolone) may have therapeutic potential for treatment of various stress-related diseases including post-traumatic ...
Giorgia Boero +2 more
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