Results 21 to 30 of about 12,622 (280)

Allopregnanolone and reproductive psychiatry: an overview [PDF]

International Review of Psychiatry, 2019
Psychiatric symptoms that coincide with reproductive transitions are related to changes in sex steroids, but studies show that this relationship is governed by individual women’s vulnerability to change rather than by differences in level.
Katherine M McEvoy, L. Osborne
semanticscholar   +3 more sources

Allopregnanolone in postpartum depression: Role in pathophysiology and treatment

Neurobiology of Stress, 2020
Postpartum depression (PPD) is a unique subtype of major depressive disorder and a substantial contributor to maternal morbidity and mortality. In addition to affecting the mother, PPD can have short- and long-term consequences for the infant and partner.
Samantha Meltzer-Brody, Stephen J. Kanes
doaj   +2 more sources

Anti-apoptotic Actions of Allopregnanolone and Ganaxolone Mediated Through Membrane Progesterone Receptors (PAQRs) in Neuronal Cells

Frontiers in Endocrinology, 2020
The neurosteroids progesterone and allopregnanolone regulate numerous neuroprotective functions in neural tissues including inhibition of epileptic seizures and cell death.
Peter Thomas, Yefei Pang
doaj   +2 more sources

Distinct mechanisms of allopregnanolone and diazepam underlie neuronal oscillations and differential antidepressant effect

Frontiers in Cellular Neuroscience
The rapid relief of depressive symptoms is a major medical requirement for effective treatments for major depressive disorder (MDD). A decrease in neuroactive steroids contributes to the pathophysiological mechanisms associated with the neurological ...
Keiko Takasu, Yosuke Yawata, Ryoichi Tashima, Hiroyuki Aritomi, Shinji Shimada, Tsukasa Onodera, Teruhiko Taishi, Koichi Ogawa   +7 more
doaj   +2 more sources

Safety, tolerability, and pharmacokinetics of allopregnanolone as a regenerative therapeutic for Alzheimer's disease: A single and multiple ascending dose phase 1b/2a clinical trial

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2020
Introduction Allopregnanolone is an endogenous neurosteroid with the potential to be a novel regenerative therapeutic for Alzheimer's disease (AD). Foundations of mechanistic understanding and well‐established preclinical safety efficacy make it a viable
Gerson D. Hernandez, Christine M. Solinsky, Wendy J. Mack, Naoko Kono, Kathleen E. Rodgers, Chun‐Yi Wu, Ana R. Mollo, Claudia M. Lopez, Sonia Pawluczyk, Gerhard Bauer, Dawn Matthews, Yonggang Shi, Meng Law, Michael A. Rogawski, Lon S. Schneider, Roberta D. Brinton   +15 more
doaj   +2 more sources

Evaluation of Midazolam-Ketamine-Allopregnanolone Combination Therapy against Cholinergic-Induced Status Epilepticus in Rats [PDF]

Journal of Pharmacology and Experimental Therapeutics, 2023
Status epilepticus (SE) is a life-threatening development of self-sustaining seizures that becomes resistant to benzodiazepines when treatment is delayed.
Donna A. Nguyen, Michael F. Stone, Caroline R. Schultz, Marcio de Araujo Furtado, Jérôme Niquet, Claude G. Wasterlain, Lucille A. Lumley   +6 more
openalex   +2 more sources

Allopregnanolone-based treatments for postpartum depression: Why/how do they work?

Neurobiology of Stress, 2019
Recent FDA approval of an allopregnanolone-based treatment specifically for postpartum depression, brexanolone, now commercially called Zulresso®, is an exciting development for patients and families impacted by postpartum depression and allows us to ...
Najah Walton, Jamie Maguire
doaj   +2 more sources

Allopregnanolone mediates affective switching through modulation of oscillatory states in the basolateral amygdala [PDF]

bioRxiv, 2021
Brexanolone (allopregnanolone), was recently approved by the FDA for the treatment of post-partum depression, demonstrating long-lasting antidepressant effects.
Pantelis Antonoudiou, Phillip L.W. Colmers, Najah Walton, Grant L. Weiss, Anne C. Smith, David P. Nguyen, Michael Lewis, Michael C. Quirk, Laverne C. Melón, Jamie Maguire   +9 more
semanticscholar   +4 more sources

Allopregnanolone and Pregnanolone Are Reduced in the Hippocampus of Epileptic Rats, but Only Allopregnanolone Correlates with Seizure Frequency

Neuroendocrinology, 2020
Background: Neurosteroids modulate epileptic activity by interacting with the γ-aminobutyric acid type A receptor, but their brain levels are still undetermined.
C. Lucchi, A. Costa, C. Rustichelli, G. Biagini   +3 more
semanticscholar   +4 more sources

Neurosteroids (allopregnanolone) and alcohol use disorder: From mechanisms to potential pharmacotherapy

Pharmacology and Therapeutics, 2022
Alcohol Use Disorder (AUD) is a multifaceted relapsing disorder that is commonly comorbid with psychiatric disorders, including anxiety. Alcohol exposure produces a plethora of effects on neurobiology.
Eleonora Gatta, Diletta Camussi, James Auta, Alessandro Guidotti, Subhash C. Pandey   +4 more
openalex   +3 more sources