Results 31 to 40 of about 12,622 (280)

Maternal Milk Allopregnanolone May Buffer Negative Associations Between Maternal Postpartum Psychological Distress and Infant Regulatory Capacity. [PDF]

Dev Psychobiol
ABSTRACT Maternal psychological distress during pregnancy and the early postpartum period is a risk factor for dysregulated affective and regulatory function in young infants. Animal models suggest that perinatal stress may alter offspring development via allopregnanolone (ALLO) exposure.
Werchan DM, Susskind B, Carpio R, Howell BR, Brito NH, Thomason ME.   +5 more
europepmc   +2 more sources

Animal Models of PTSD: The Socially Isolated Mouse and the Biomarker Role of Allopregnanolone

Frontiers in Behavioral Neuroscience, 2019
Post-traumatic stress disorder (PTSD) is a debilitating undertreated condition that affects 8%–13% of the general population and 20%–30% of military personnel.
Graziano Pinna
doaj   +2 more sources

Allopregnanolone Assays [PDF]

Journal of Clinical Endocrinology & Metabolism, 2001
Author's Response: Allopregnanolone ...
Pearson Murphy, Beverley E., Petraglia, Felice   +1 more
openaire   +2 more sources

Preclinical and clinical pharmacology of brexanolone (allopregnanolone) for postpartum depression: a landmark journey from concept to clinic in neurosteroid replacement therapy

Psychopharmacology, 2023
This article describes the critical role of neurosteroids in postpartum depression (PPD) and outlines the landmark pharmacological journey of brexanolone as a first-in-class neurosteroid antidepressant with significant advantages over traditional ...
D. Reddy, Robert H. Mbilinyi, Emily Estes   +2 more
semanticscholar   +1 more source

The Role of HPA Axis and Allopregnanolone on the Neurobiology of Major Depressive Disorders and PTSD

International Journal of Molecular Sciences, 2021
Under stressful conditions, the hypothalamic-pituitary-adrenal (HPA) axis acts to promote transitory physiological adaptations that are often resolved after the stressful stimulus is no longer present. In addition to corticosteroids (e.g., cortisol), the
F. B. Almeida, G. Pinna, H. Barros
semanticscholar   +1 more source

Allopregnanolone Is Associated with a Stress-Induced Reduction of Heart Rate Variability in Premenstrual Dysphoric Disorder

Journal of Clinical Medicine, 2023
Human survival and wellbeing require appropriate responses to stress, including a highly coordinated and efficient nervous system control of the heart rhythm.
A. Hamidovic, John Davis, Fatimata Soumare, Aamina Naveed, Yaseen Ghani, Selma Semiz, D. Khalil, Margaret C. Wardle   +7 more
semanticscholar   +1 more source

Serum levels of allopregnanolone, progesterone and testosterone in menstrually-related and postmenopausal migraine: A cross-sectional study [PDF]

Cephalalgia, 2020
Background Reduced blood or cerebrospinal fluid levels of allopregnanolone are involved in menstrual cycle-linked CNS disorders, such as catamenial epilepsy.
Cecilia Rustichelli, Elisa Bellei, Stefania Bergamini, Emanuela Monari, Carlo Baraldi, Flavia Lo Castro, Aldo Tomasi, Anna Ferrari   +7 more
openalex   +2 more sources

Exploring Novel Therapeutic Approaches for Depressive Disorders: The Role of Allopregnanolone Agonists

Cureus, 2023
Depressive disorders are caused due to the impaired functioning of important brain networks. Recent studies have also shown that it is caused by a significant reduction in the levels of allopregnanolone, which is a progesterone metabolite.
Najeeha A Bhatti, Anna Jobilal, Kainat Asif, Mateo Jaramillo Villegas, Priyanka Pandey, Ayzal Noor Tahir, Neeharika Balla, Maryoreht Paola Arellano Camargo, Sana Ahmad, Janvi Kataria, Z. Abdin, M. Ayyan   +11 more
semanticscholar   +1 more source

Neurosteroid Activation of GABA-A Receptors: A Potential Treatment Target for Symptoms in Primary Biliary Cholangitis?

Canadian Journal of Gastroenterology and Hepatology, 2022
Background and Aims. A third of patients with primary biliary cholangitis (PBC) experience poorly understood cognitive symptoms, with a significant impact on quality of life (QOL), and no effective medical treatment.
Aaron Wetten, Laura Ogle, George Mells, Vinod S. Hegade, Laura Jopson, Margaret Corrigan, Jeremy Palmer, Maja Johansson, Torbjörn Bäckström, Magnus Doverskog, David E. J. Jones, Jessica K. Dyson   +11 more
doaj   +1 more source

Reduced neurosteroid potentiation of GABAA receptors in epilepsy and depolarized hippocampal neurons [PDF]

, 2020
OBJECTIVE: Neurosteroids regulate neuronal excitability by potentiating γ-aminobutyric acid type-A receptors (GABARs). In animal models of temporal lobe epilepsy, the neurosteroid sensitivity of GABARs is diminished and GABAR subunit composition is ...
Jansen, Laura A, Joshi, Suchitra, Kapur, Jaideep, Roden, William H   +3 more
core   +2 more sources