Results 41 to 50 of about 12,622 (280)

Allopregnanolone concentrations and premenstrual syndrome [PDF]

European Journal of Endocrinology, 2000
OBJECTIVE: To evaluate basal allopregnanolone and progesterone in both phases of the menstrual cycle in women suffering from premenstrual syndrome (PMS) and their response to a GnRH test. DESIGN: We selected 56 women (28 patients with PMS and 28 controls) aged between 18 and 32 years. Blood samples were drawn in both follicular and phases. Twenty-eight
Monteleone, P, Luisi, S, Tonetti, A, Bernardi, F, GENAZZANI, Alessandro, Luisi, M, Petraglia, F, Genazzani, A. R.   +7 more
openaire   +6 more sources

Early postnatal allopregnanolone levels alteration and adult behavioral disruption in rats: Implication for drug abuse

Neurobiology of Stress, 2020
Several studies have highlighted the role that early postnatal levels of allopregnanolone play in the development of the CNS and adult behavior. Changes in allopregnanolone levels related to stress have been observed during early postnatal periods, and ...
Iris Bartolomé, Anna Llidó, Sònia Darbra, Marc Pallarès   +3 more
doaj   +1 more source

Allopregnanolone Concentrations in Breast Milk and Plasma from Healthy Volunteers Receiving Brexanolone Injection, With Population Pharmacokinetic Modeling of Potential Relative Infant Dose

Clinical Pharmacokinetics, 2022
Women with postpartum depression (PPD) may expose their infants to antidepressants via breast milk. Brexanolone is the only FDA-approved antidepressant specifically indicated for the treatment of PPD.
J. Wald, A. Henningsson, Eva Hanze, E. Hoffmann, Haihong Li, H. Colquhoun, K. Deligiannidis   +6 more
semanticscholar   +1 more source

Exploratory imaging outcomes of a phase 1b/2a clinical trial of allopregnanolone as a regenerative therapeutic for Alzheimer's disease: Structural effects and functional connectivity outcomes

Alzheimer's & Dementia, 2022
Allopregnanolone (ALLO), an endogenous neurosteroid, promoted neurogenesis and oligogenesis and restored cognitive function in animal models of Alzheimer's disease (AD).
A. Raikes, Gerson D. Hernandez, D. Matthews, A. Lukic, Meng Law, Yonggang Shi, L. Schneider, R. Brinton   +7 more
semanticscholar   +1 more source

Role of allopregnanolone on cerebellar granule cells neurogenesis

Developmental Brain Research, 2004
The role of allopregnanolone on immature cerebellar granule cells (CGC) proliferation was studied. Allopregnanolone (0.1-1 microM) increased [(3)H]thymidine incorporation and cell number determined by neuronal counting and by an MTT colorimetric assay.
E. Keller, Andrea L. Zamparini, Laura N. Borodinsky, Marı́a Clara Gravielle, M.L. Fiszman   +4 more
openalex   +5 more sources

Inhibition of human macrophage activation via pregnane neurosteroid interactions with toll-like receptors: Sex differences and structural requirements

Frontiers in Immunology, 2022
We recently discovered that (3α,5α)3-hydroxypregnan-20-one (allopregnanolone) inhibits pro-inflammatory toll-like receptor (TLR) activation and cytokine/chemokine production in mouse macrophage RAW264.7 cells.
Irina Balan, Laure Aurelian, Kimberly S. Williams, Brian Campbell, Rick B. Meeker, A. Leslie Morrow   +5 more
doaj   +1 more source

Allopregnanolone in premenstrual dysphoric disorder (PMDD): Evidence for dysregulated sensitivity to GABA-A receptor modulating neuroactive steroids across the menstrual cycle

Neurobiology of Stress, 2020
Premenstrual dysphoric disorder (PMDD) is a severe mood disorder with core symptoms (affective lability, irritability, depressed mood, anxiety) and increased sensitivity to stress occurring in the luteal phase of the menstrual cycle.
Liisa Hantsoo, C. Epperson
semanticscholar   +1 more source

Realising the therapeutic potential of neuroactive steroid modulators of the GABA_A receptor [PDF]

, 2020
In the 1980s particular endogenous metabolites of progesterone and of deoxycorticosterone were revealed to be potent, efficacious, positive allosteric modulators (PAMs) of the GABAA receptor (GABAAR).
Belelli, Delia, Gee, Kelvin W., Hogenkamp, Derk, Lambert, Jeremy J.   +3 more
core   +1 more source

Allopregnanolone: Metabolism, Mechanisms of Action, and Its Role in Cancer

International Journal of Molecular Sciences, 2022
Allopregnanolone (3α-THP) has been one of the most studied progesterone metabolites for decades. 3α-THP and its synthetic analogs have been evaluated as therapeutic agents for pathologies such as anxiety and depression. Enzymes involved in the metabolism
Carmen J Zamora-Sánchez, I. Camacho-Arroyo   +1 more
semanticscholar   +1 more source

The relationship between weight gain during pregnancy and allopregnanolone levels: a longitudinal study

Endocrine Connections, 2017
Objective: Large weight gain during pregnancy is a risk factor for complications for mother and fetus. Hunger and satiety are regulated in the hypothalamus, where the gamma-amino-butyric acid system (GABA) has an important role.
Anette Lundqvist, Herbert Sandström, Torbjörn Bäckström   +2 more
doaj   +1 more source