Results 91 to 100 of about 61,179 (292)
JEADV Clinical Practice, EarlyView.ABSTRACT Background Epidermal necrolysis (EN), including Stevens‐Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), are severe cutaneous drug reactions with high morbidity. However, the quality of life (QoL) impact during acute hospitalization is not well understood.
Jacob McFeeters +9 more
wiley +1 more source
Opposing effects of TIGAR- and RAC1-derived ROS on Wnt-driven proliferation in the mouse intestine [PDF]
, 2016 Reactive oxygen species (ROS) participate in numerous cell responses, including proliferation, DNA damage, and cell death. Based on these disparate activities, both promotion and inhibition of ROS have been proposed for cancer therapy.
Blyth, Karen +6 more
core +1 more source
The Sooner, the Better: Neuroprotective Strategies in Fetuses With Congenital Heart Disease
Prenatal Diagnosis, EarlyView.ABSTRACT Congenital heart disease (CHD) is the most frequent congenital malformation at birth and is associated with neurodevelopmental impairments. Alterations in cardiovascular physiology can lead to reduced cerebral blood perfusion and oxygenation, which negatively affects brain growth and maturation.
Maaike Nijman +7 more
wiley +1 more source
Hellenic Journal of Cardiology, 2017 Objective: To investigate the therapeutic effect of allopurinol treatment on acute coronary syndrome and to elucidate its possible mechanism. Methods: Patients with acute coronary syndrome (n = 100) were recruited as research subjects in our hospital ...
Ying Huang +7 more
doaj +1 more source
Long‐term remission in gout: Challenges and future opportunities
Rheumatology &Autoimmunity, EarlyView.Prolonged hyperuricemia is a major risk factor for gout, which is now regarded as a curable disease. Awareness of the various factors that can trigger gout flares is essential for their prevention. An important determinant of treatment decisions and long‐term follow‐up is the quality of the clinician–patient relationship. The “treat‐to‐target” approach
Patapong Towiwat, Zhanguo Li
wiley +1 more source
Cancer Science, EarlyView.ABSTRACT In the randomized phase III CheckMate 77T study, perioperative nivolumab showed statistically significant and clinically meaningful improvement in event‐free survival (EFS) vs. placebo in patients with resectable, non‐metastatic non‐small cell lung cancer (NSCLC).
Fumihiro Tanaka +17 more
wiley +1 more source
Zaporožskij Medicinskij Žurnal, 2017 Objective – to study the effectiveness of Allopurinol and Quercetin inclusion in a complex treatment of stable angina pectoris and peculiarities of biomarkers and homeostatic indices changes. Materials and Methods.
V.K. Tashchuk +2 more
doaj +1 more source
Diabetes Care, 2019 OBJECTIVE Higher serum uric acid (SUA) is associated with diabetic kidney disease (DKD). Preventing Early Renal Loss in Diabetes (PERL) evaluates whether lowering SUA with allopurinol slows glomerular filtration rate (GFR) loss in people with type 1 ...
M. Afkarian +33 more
semanticscholar +1 more source
Climate change and the kidney [PDF]
, 2019 The worldwide increase in temperature has resulted in a marked increase in heat waves (heat extremes) that carries a markedly increased risk for morbidity and mortality.
Butler-Dawson, Jaime +12 more
core +1 more source
Cell Proliferation, EarlyView.Supplementing the liver preservation solution with agrimoniin protects donation after cardiac death (DCD) grafts by activating the Nrf‐2 pathway. This reduces ferroptosis, oxidative stress, and inflammation during cold storage, significantly improving graft viability.
Enqiang Chang +5 more
wiley +1 more source