Results 11 to 20 of about 46,519 (250)

Response to allopurinol and febuxostat according to the fractional excretion of urate in men with gout [PDF]

Arthritis Care &Research, Accepted Article.
Background Body mass index (BMI), glomerular filtration rate (GFR), and pretreatment urate levels have been reported to influence the urate‐lowering response to allopurinol. We investigated whether the fractional excretion of urate (FEUA) also modulates this response and relates to oxypurinol concentrations. We further evaluated its potential influence
Pascal Richette, Anouk Walter‐Petrich, Quang Dinh Nguyen, Matthieu Resche-Rigon, Quang Huy Dinh Nguyen, Minh Duc Do, Thao Phuong Mai, Tuan Duc Nguyen, Fernando Pérez Ruiz, Emmanuel Letavernier, Tristan Pascart, Augustin Latourte, Hang-Korng Ea, Thomas Bardin, Pascal Richette, Anouk Walter‐Petrich, Quang Dinh Nguyen, Matthieu Resche-Rigon, Quang Huy Dinh Nguyen, Minh Duc Do, Thao Phuong Mai, Tuan Duc Nguyen, Fernando Pérez Ruiz, Emmanuel Letavernier, Tristan Pascart, Augustin Latourte, Hang-Korng Ea, Thomas Bardin   +27 more
openalex   +2 more sources

Delayed hypersensitivity reaction to allopurinol: A case report [PDF]

Malaysian Family Physician, 2023
Allopurinol is the well-known first-line treatment option for symptomatic hyperuricaemia and gout. It is cost-effective particularly for the management of chronic gout.
Mohammad Che Man, Shahidah Che Alhadi, Wan Fatimah Suriyani Wan Mahmud, Salman Amiruddin, Mohd Zhafri Mohd Razib, Rasimah Ismail   +5 more
doaj   +1 more source

Impact of Urate Level on Cardiovascular Risk in Allopurinol Treated Patients. A Nested Case-Control Study. [PDF]

PLoS ONE, 2016
BACKGROUND:Gout gives rise to increased risk of cardiovascular events. Gout attacks can be effectively prevented with urate lowering drugs, and allopurinol potentially reduces cardiovascular risk.
Kasper Søltoft Larsen, Anton Pottegård, Hanne M Lindegaard, Jesper Hallas   +3 more
doaj   +1 more source

Allopurinol Treatment Improves Cognitive Skills, Adaptive Behavior, and Biochemical Markers in Young Patients With Adenylosuccinate Lyase Deficiency. [PDF]

J Inherit Metab Dis
ABSTRACT Adenylosuccinate lyase deficiency (ADSLD) is a rare neurological disorder characterized by psychomotor retardation, autistic behaviors, and seizures, with no specific treatment available. ADSL catalyzes the transformation of succinylaminoimidazole carboxamide ribotide (SAICAr) to AICAR, and succinyl‐AMP (S‐AMP) to AMP.
Rousselot-Pailley B, Semeraro M, Marquant F, Robel L, Gitiaux C, Kaminska A, Mochel F, Bakouboula P, Elie C, Hennequin C, Ceballos-Picot I, Sanquer S, de Lonlay P.   +12 more
europepmc   +2 more sources

Allopurinol for Secondary Prevention in Patients with Cardiovascular Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Journal of Cardiovascular Development and Disease, 2023
Background: The effects of allopurinol in patients with cardiovascular disease are not well defined; therefore, the latest evidence is summarized in this study. Methods: PubMed, Embase, Cochrane Library, and ClinicalTrials.gov databases were searched for
Yuyang Ye, Guangzhi Liao, Ting Liu, Xinru Hu, Xuefeng Chen, Lin Bai, Yong Peng   +6 more
doaj   +1 more source

A case series of allopurinol-induced toxic epidermal necrolysis

Indian Journal of Dermatology, 2011
This is a case series of allopurinol-induced toxic epidermal necrolysis. Revisiting the indications of using allopurinol in asymptomatic hyperuricemia and a critical reappraisal of the safety profile of allopurinol is done in this article.
Harneet Ranu, Jackson Jiang, Pang Shiu Ming   +2 more
doaj   +1 more source

Allopurinol Versus Febuxostat Use and the Risk of Cardiovascular Disease in People With Chronic Kidney Disease: A New-User Active Comparator Cohort Study. [PDF]

Nephrology (Carlton)
This retrospective cohort study assessed the cardiovascular outcomes in people with chronic kidney disease who were newly prescribed allopurinol or febuxostat. ABSTRACT Aim Hyperuricaemia, a common comorbidity among people with chronic kidney disease, is widely treated with uric acid‐lowering agents such as allopurinol and febuxostat.
Inoue R, Yamaguchi S, Okada A, Yamauchi T, Kadowaki T, Nangaku M.   +5 more
europepmc   +2 more sources

The role of urate and xanthine oxidase in vascular oxidative stress:Future directions [PDF]

, 2009
Vascular oxidative stress has been shown to be a potent factor in the pathophysiology of endothelial dysfunction. Despite current optimal evidence-based therapy, mortality from various cardiovascular disorders remains high.
George, Jacob, Struthers, Allan
core   +5 more sources

Allopurinol use yields potentially beneficial effects on inflammatory indices in those with recent ischemic stroke: a randomized, double-blind, placebo-controlled trial [PDF]

, 2008
<p><b>Background and Purpose</b>: Elevated serum uric acid level is associated with poor outcome and increased risk of recurrent events after stroke.
Dawson, J., Harrow, C., Lees, K.R., Muir, S.W., Sattar, N., Walters, M.R., Weir, C.J.   +6 more
core   +1 more source

Evaluation of the effect of allopurinol as a protective factor in post ischemia and reperfusion inflammation in Wistar rats [PDF]

Acta Cirúrgica Brasileira, 2016
PURPOSE: To investigate the potential protective effect of allopurinol on reperfusion injury by determining the inflammatory response through the measurement of tumor necrosis factor-alpha (TNF-alpha).
Ricardo Zanetti Gomes, Gabriela Moreira Mahle Romanek, Michella Przybycien, Danielli Cristina Amaral, Hugo Genki Kagawa Akahane   +4 more
doaj   +1 more source