Results 11 to 20 of about 58,710 (306)
Inflammation, 2022 SARS-CoV-2 by the direct cytopathic effect or indirectly through the propagation of pro-inflammatory cytokines could cause endothelial dysfunction (ED) and oxidative stress (OS).
H. Al-kuraishy +6 more
semanticscholar +1 more source
Comparative Effectiveness of Allopurinol and Febuxostat in Gout Management.
NEJM Evidence, 2022 BACKGROUND The relative efficacy and safety of allopurinol and febuxostat when used according to current guidelines for the treatment of hyperuricemia are unknown. This double-blind noninferiority trial examined these issues.
J. O'dell +16 more
semanticscholar +1 more source
Annals of Internal Medicine, 2022 BACKGROUND Two recent randomized clinical trials of escalating doses of allopurinol for the progression of chronic kidney disease (CKD) reported no benefits but potentially increased risk for death.
Jie Wei +11 more
semanticscholar +1 more source
A Novel Use of Allopurinol as A Quorum-Sensing Inhibitor in Pseudomonas aeruginosa
Antibiotics, 2021 Pseudomonas aeruginosa can cause a variety of healthcare-associated infections by its arsenal of virulence factors. Virulence factor production is largely controlled by the cell-to-cell communication system termed quorum sensing (QS). Targeting QS may be
A. A. Saqr +5 more
semanticscholar +1 more source
Cardiovascular risk associated with allopurinol vs. benzbromarone in patients with gout
European Heart Journal, 2021 Aims With the high prevalence of gout and associated cardiovascular (CV) diseases, information on the comparative CV safety of individual urate-lowering drugs becomes increasingly important. However, few studies examined the CV risk of uricosuric agents.
E. Kang +4 more
semanticscholar +1 more source
Xanthine oxidase and aldehyde oxidase contribute to allopurinol metabolism in rats
Journal of Pharmaceutical Health Care and Sciences, 2022 Background Allopurinol is used to treat hyperuricemia and gout. It is metabolized to oxypurinol by xanthine oxidase (XO), and aldehyde oxidase (AO). Allopurinol and oxypurinol are potent XO inhibitors that reduce the plasma uric acid levels.
Yoshitaka Tayama +5 more
doaj +1 more source
Clinical Cardiology, 2021 The cardiovascular safety of febuxostat compared to allopurinol for the treatment of gout remains equivocal. Febuxostat had a better safety outcome compared with allopurinol. In this systematic review and meta‐analysis, we searched MEDLINE and Embase for
Linggen Gao +4 more
semanticscholar +1 more source
Allopurinol hepatotoxicity is associated with human leukocyte antigen Class I alleles
Liver international (Print), 2021 Allopurinol can cause HLA class I‐associated life‐threatening severe skin reactions. However, HLA risk and association with clinical features in allopurinol hepatotoxicity are unknown.
R. Fontana +6 more
semanticscholar +1 more source
Journal of International Medical Research, 2021 Objective Heart failure (HF) is a common and highly morbid cardiovascular disorder. Oxidative stress worsens HF, and uric acid (UA) is a useful oxidative stress marker.
Satoshi Suzuki +16 more
semanticscholar +1 more source