Results 21 to 30 of about 61,179 (292)
A Novel Use of Allopurinol as A Quorum-Sensing Inhibitor in Pseudomonas aeruginosa
Antibiotics, 2021 Pseudomonas aeruginosa can cause a variety of healthcare-associated infections by its arsenal of virulence factors. Virulence factor production is largely controlled by the cell-to-cell communication system termed quorum sensing (QS). Targeting QS may be
A. A. Saqr +5 more
semanticscholar +1 more source
Effect of allopurinol on phosphocreatine recovery and muscle function in older people with impaired physical function:a randomised controlled trial [PDF]
, 2020 Background: Allopurinol has vascular antioxidant effects and participates in purinergic signalling within muscle. We tested whether allopurinol could improve skeletal muscle energetics and physical function in older people with impaired physical ...
Cavin, Ian +10 more
core +2 more sources
Clinical Cardiology, 2021 The cardiovascular safety of febuxostat compared to allopurinol for the treatment of gout remains equivocal. Febuxostat had a better safety outcome compared with allopurinol. In this systematic review and meta‐analysis, we searched MEDLINE and Embase for
Linggen Gao +4 more
semanticscholar +1 more source
Delayed hypersensitivity reaction to allopurinol: A case report [PDF]
Malaysian Family Physician, 2023 Allopurinol is the well-known first-line treatment option for symptomatic hyperuricaemia and gout. It is cost-effective particularly for the management of chronic gout.
Mohammad Che Man +5 more
doaj +1 more source
Journal of International Medical Research, 2021 Objective Heart failure (HF) is a common and highly morbid cardiovascular disorder. Oxidative stress worsens HF, and uric acid (UA) is a useful oxidative stress marker.
Satoshi Suzuki +16 more
semanticscholar +1 more source
Clinical and Translational Science, 2020 The aims of this study were to determine factors that predict serum urate (SU) lowering response to allopurinol and the conversion of allopurinol to oxypurinol, and to determine a minimum therapeutic oxypurinol concentration.
Lisa K. Stamp +8 more
doaj +1 more source
Allopurinol hepatotoxicity is associated with human leukocyte antigen Class I alleles
Liver international (Print), 2021 Allopurinol can cause HLA class I‐associated life‐threatening severe skin reactions. However, HLA risk and association with clinical features in allopurinol hepatotoxicity are unknown.
R. Fontana +6 more
semanticscholar +1 more source
Impact of Urate Level on Cardiovascular Risk in Allopurinol Treated Patients. A Nested Case-Control Study. [PDF]
PLoS ONE, 2016 BACKGROUND:Gout gives rise to increased risk of cardiovascular events. Gout attacks can be effectively prevented with urate lowering drugs, and allopurinol potentially reduces cardiovascular risk.
Kasper Søltoft Larsen +3 more
doaj +1 more source
Allopurinol to reduce cardiovascular morbidity and mortality: A systematic review and meta-analysis
PLoS ONE, 2021 Aims To compare the effectiveness of allopurinol with no treatment or placebo for the prevention of cardiovascular events in hyperuricemic patients. Methods and results Pubmed, Web of Science and Cochrane library were searched from inception until July ...
K. H. van der Pol +5 more
semanticscholar +1 more source
Journal of Cardiovascular Development and Disease, 2023 Background: The effects of allopurinol in patients with cardiovascular disease are not well defined; therefore, the latest evidence is summarized in this study. Methods: PubMed, Embase, Cochrane Library, and ClinicalTrials.gov databases were searched for
Yuyang Ye +6 more
doaj +1 more source