Results 21 to 30 of about 46,519 (250)

Gout [PDF]

, 2008
INTRODUCTION: Gout affects about 5% of men and 1% of women, with up to 80% of people experiencing a recurrent attack within 3 years. METHODS AND OUTCOMES:We conducted a systematic review and aimed to answer the following clinical questions: What are the
Underwood, Martin
core   +3 more sources

PSORS1C1 Hypomethylation Is Associated with Allopurinol-Induced Severe Cutaneous Adverse Reactions during Disease Onset Period: A Multicenter Retrospective Case-Control Clinical Study in Han Chinese

Frontiers in Pharmacology, 2018
Background: Allopurinol-induced severe cutaneous adverse reactions (SCARs), including drug rash with eosinophilia and systemic symptoms (DRESS), Stevens-Johnson syndrome (SJS) and toxic epidermal necrosis (TEN), are life-threatening autoimmune reactions.
Bao Sun, Bao Sun, Lin Cheng, Lin Cheng, Yan Xiong, Yan Xiong, Lei Hu, Zhiying Luo, Zhiying Luo, Maosong Zhou, Ji Li, Hongfu Xie, Fazhong He, Fazhong He, Xiaoqing Yuan, Xiaoqing Yuan, Xiaoping Chen, Xiaoping Chen, Hong-Hao Zhou, Hong-Hao Zhou, Zhaoqian Liu, Zhaoqian Liu, Xiang Chen, Xiang Chen, Wei Zhang, Wei Zhang   +25 more
doaj   +1 more source

Examining the use of allopurinol: Perspectives from recent drug injury relief applications

Journal of the Formosan Medical Association, 2019
Background/purpose: Previous studies have reported that the indication and starting dose of allopurinol may be associated with the incidence of hypersensitive reactions.
Chu-Han Huang, Mei-Pei Chu, Wen-Wen Chen
doaj   +1 more source

Allopurinol reduces antigen-specific and polyclonal activation of human T cells

Frontiers in Immunology, 2012
Allopurinol is the most popular commercially available xanthine oxidase inhibitor and it is widely used for treatment of symptomatic hyperuricaemia, or gout. Although, several anti-inflammatory actions of allopurinol have been demonstrated in vivo and in
Damián ePérez-Mazliah, María Cecilia Albareda, María Gabriela Alvarez, Bruno Edgardo Lococo, Graciela Luciana Bertocchi, Marcos ePetti, Rodolfo eViotti, Susana Adriana Laucella   +7 more
doaj   +1 more source

Comparative Study of Allopurinol and Uralyt-4 in patients with Hyperuricemia in Diyala Governorate.

مجلة كلية الطب, 2014
Background: Hyperuricemia represents a major public health problem; approximately most population has hyperuricemia, serum uric acid ≥6.5 mg/dL in women and ≥7.0 mg/dL in men.
Zuhir M. Hussein, Areej A. Hussein, Qutaybaa G. Hussein   +2 more
doaj   +1 more source

Effects of Allopurinol as a xanthine oxidase inhibitor on depressive-like behavior of rats and changes in serum BDNF level

IBRO Neuroscience Reports, 2022
Background: Depression is a psychiatric disorder characterized by low mood and loss of interest in daily activities. Allopurinol, a xanthine oxidase blocker, is widely administered for the treatment of hyperuricemia.
Mahsa Hadipour Jahromy, Bahareh Baghchesara, Salar Javanshir   +2 more
doaj   +1 more source

Acute kidney injury in critically ill cancer patients : an update [PDF]

, 2016
Patients with cancer represent a growing group among actual ICU admissions (up to 20 %). Due to their increased susceptibility to infectious and noninfectious complications related to the underlying cancer itself or its treatment, these patients ...
Benoit, Dominique, Lameire, Norbert, Van Biesen, Wim, Vanholder, Raymond   +3 more
core   +2 more sources

Skin rash, eosinophilia, and renal impairment in a patient recently started on allopurinol

Journal of Family Medicine and Primary Care, 2016
Allopurinol is a hypoxanthine analog which inhibits xanthine oxidase, it is a widely used medication for the treatment of hyperuricemia and gout. Allopurinol-induced drug-induced rash with eosinophilia and systemic symptoms syndrome is an infrequent ...
Ashraf Jmeian, Amer Hawatmeh, Razan Shamoon, Fayez Shamoon, Michael Guma   +4 more
doaj   +1 more source

Allopurinol-Induced Stevens–Johnson Syndrome in Javanese Men With Positive HLA‐B*58:01

Frontiers in Genetics, 2022
Background: Allopurinol is the most commonly used drug for the treatment of gout arthritis. However, the use of allopurinol is associated with severe cutaneous adverse reactions (SCARs) and life-threatening immune-mediated reactions that include Stevens ...
Astri Ferdiana, Astri Ferdiana, Astri Ferdiana, Jajah Fachiroh, Dyah Ayu Mira Oktarina, Astrid Irwanto, Caroline Mahendra, Sri Awalia Febriana, Hardyanto Soebono   +8 more
doaj   +1 more source

How to improve drug dosing for patients with renal impairment in primary care - a cluster-randomized controlled trial [PDF]

, 2012
Background: Patients with chronic kidney disease (CKD) are at increased risk for inappropriate or potentially harmful prescribing. The aim of this study was to examine whether a multifaceted intervention including the use of a software programme for the ...
Beyer, Martin, Erler, Antje, Gerlach, Ferdinand M., Haefeli, Walter E., Petersen, Juliana, Rath, Thomas, Rochon, Justine, Saal, Kristina   +7 more
core   +1 more source