Allopurinol to reduce cardiovascular morbidity and mortality: A systematic review and meta-analysis
PLoS ONE, 2021 Aims To compare the effectiveness of allopurinol with no treatment or placebo for the prevention of cardiovascular events in hyperuricemic patients. Methods and results Pubmed, Web of Science and Cochrane library were searched from inception until July ...
K. H. van der Pol +5 more
semanticscholar +1 more source
Effects of Allopurinol on the Progression of Chronic Kidney Disease.
New England Journal of Medicine, 2020 BACKGROUND Elevated serum urate levels are associated with progression of chronic kidney disease. Whether urate-lowering treatment with allopurinol can attenuate the decline of the estimated glomerular filtration rate (eGFR) in patients with chronic ...
S. Badve +23 more
semanticscholar +1 more source
Serum Urate Lowering with Allopurinol and Kidney Function in Type 1 Diabetes.
New England Journal of Medicine, 2020 BACKGROUND Higher serum urate levels are associated with an increased risk of diabetic kidney disease. Lowering of the serum urate level with allopurinol may slow the decrease in the glomerular filtration rate (GFR) in persons with type 1 diabetes and ...
A. Doria +35 more
semanticscholar +1 more source
Clinical and Translational Science, 2020 The aims of this study were to determine factors that predict serum urate (SU) lowering response to allopurinol and the conversion of allopurinol to oxypurinol, and to determine a minimum therapeutic oxypurinol concentration.
Lisa K. Stamp +8 more
doaj +1 more source
An association study of ABCG2 rs2231142 on the concentrations of allopurinol and its metabolites
Clinical and Translational Science, 2022 ABCG2 is a gene that codes for the human breast cancer resistance protein (BCRP). It is established that rs2231142 G>T, a single nucleotide polymorphism of the ABCG2 gene, is associated with gout and poor response to allopurinol, a uric acid‐lowering ...
Marc‐Olivier Pilon +11 more
doaj +1 more source
Delayed hypersensitivity reaction to allopurinol: A case report [PDF]
Malaysian Family Physician, 2023 Allopurinol is the well-known first-line treatment option for symptomatic hyperuricaemia and gout. It is cost-effective particularly for the management of chronic gout.
Mohammad Che Man +5 more
doaj +1 more source
Impact of Urate Level on Cardiovascular Risk in Allopurinol Treated Patients. A Nested Case-Control Study. [PDF]
PLoS ONE, 2016 BACKGROUND:Gout gives rise to increased risk of cardiovascular events. Gout attacks can be effectively prevented with urate lowering drugs, and allopurinol potentially reduces cardiovascular risk.
Kasper Søltoft Larsen +3 more
doaj +1 more source
Uric acid enhances longevity and endurance and protects the brain against ischemia [PDF]
, 2020 Among mammals, there is a positive correlation between serum uric acid (UA) levels and life span. Humans have high levels of UA because they lack a functional urate oxidase (UOX) enzyme that is present in shorter lived mammals.
Argüelles Castilla, Sandro +6 more
core +1 more source
A case series of allopurinol-induced toxic epidermal necrolysis
Indian Journal of Dermatology, 2011 This is a case series of allopurinol-induced toxic epidermal necrolysis. Revisiting the indications of using allopurinol in asymptomatic hyperuricemia and a critical reappraisal of the safety profile of allopurinol is done in this article.
Harneet Ranu +2 more
doaj +1 more source
Role of urate, xanthine oxidase and the effects of allopurinol in vascular oxidative stress [PDF]
, 2009 Oxidative stress plays an important role in the progression of vascular endothelial dysfunction. The two major systems generating vascular oxidative stress are the NADPH oxidase and the xanthine oxidase pathways. Allopurinol, a xanthine oxidase inhibitor,
George, Jacob, Struthers, Allan D.
core +3 more sources