Results 71 to 80 of about 2,738 (186)

Maternal–Foetal HLA‐DQB1 Incompatibility Is Associated With Pregnancy‐Induced Hypertensive Disorders in a Genetically Isolated Population

HLA, Volume 106, Issue 2, August 2025.
ABSTRACT In pregnancy, semi‐allogenic foetal trophoblasts express a specific HLA profile mediating maternal leukocyte contact, crucial for placentation. Paradoxically, maternal immunomodulation requires foetal antigen recognition, especially involving certain HLA molecules. Pre‐eclampsia, a severe hypertensive complication, has been linked to antigenic
Liseanne J. van’t Hof, Marie‐Louise P. van der Hoorn, Selena Migdis, Geert W. Haasnoot, Emma T. M. Peereboom, Eric Spierings, Pieter J. E. van der Linden, Jacqueline D. H. Anholts, Heleen de Vreede, Winnie Ottenhof, Dave L. Roelen, Michael Eikmans, Inge B. Mathijssen, Lisa E. E. L. O. Lashley   +13 more
wiley   +1 more source

CWI‐MAPKs Regulate the Formation of Hyphopodia Required for Virulence in Ceratocystis fimbriata

Molecular Plant Pathology, Volume 26, Issue 7, July 2025.
The Slt2‐Swi6 pathway is crucial for the pathogenicity of Ceratocystis fimbriata. It regulates septin assembly at the base of the penetration peg, thereby influencing penetration peg formation—a key virulence determinant. ABSTRACT Ceratocystis fimbriata is a destructive fungal pathogen that infects various economic crops.
Kailun Lu, Hao Cong, Ru Xin, Yong Sun, Qinghe Cao, Lianwei Li, Jihong Jiang   +6 more
wiley   +1 more source

Allogeneic HLA Humoral Immunogenicity and the Prediction of Donor-Specific HLA Antibody Development

Antibodies
The development of de novo donor-specific HLA antibodies (dnDSAs) following solid organ transplantation is considered a major risk factor for poor long-term allograft outcomes.
Vadim Jucaud
doaj   +1 more source

The role of self-peptides in direct T cell allorecognition [PDF]

, 2021
Hossam A. Abdelsamed, Fadi G. Lakkis
openalex   +1 more source

Substitution of Glutamic Acid at Position 71 of DRβ1*04:01 and Collagen‐Specific Tolerance Without Alloreactivity

Arthritis &Rheumatology, Volume 77, Issue 5, Page 526-535, May 2025.
Objective The DRB1 locus is strongly associated with both susceptibility and resistance to rheumatoid arthritis (RA). DRB1 alleles encoding the VKA or VRA epitope in positions 11, 71, and 74 confer the highest risk of developing RA, whereas the allele encoding VEA is protective.
Vibha Jha, Brian M. Freed, Elizabeth R. Sunderhaus, Jessica E. Lee, Edward B. Prage, Manjula Miglani, Edward F. Rosloniec, Jennifer L. Matsuda, Marilyne G. Coulombe, Amy S. McKee, Christina L. Roark   +10 more
wiley   +1 more source

Ex Vivo Normothermic Perfusion Induces Donor-Derived Leukocyte Mobilization and Removal Prior to Renal Transplantation

Kidney International Reports, 2016
Ex vivo normothermic perfusion offers an alternative method of organ preservation, allowing donor kidneys to be reanimated and evaluated prior to transplantation.
John P. Stone, Alexandra L. Ball, William R. Critchley, Triin Major, Rebecca J. Edge, Kavit Amin, Marc J. Clancy, James E. Fildes   +7 more
doaj   +1 more source

Correction to: Multiple Alr genes exhibit allorecognition-associated variation in the colonial cnidarian Hydractinia [PDF]

, 2022
Henry Rodriguez-Valbuena, Andrea González-Muñoz, Luis F. Cadavid   +2 more
openalex   +1 more source

Unlocking Transplant Tolerance with Biomaterials

Advanced Healthcare Materials, Volume 14, Issue 5, February 18, 2025.
Transplantation holds great promise, but the lack of long‐term success outcomes highlights the need for more targeted therapeutics and insights from immune rejection mechanisms. This review delves into how biomaterials offer a versatile toolbox for engineering next‐generation therapeutics, emphasizing the inherent properties of materials that suit ...
John‐Paul A. Pham, María M. Coronel
wiley   +1 more source

Discovery of conserved peptide-MHC epitopes for directly alloreactive CD8+ T cells

Frontiers in Transplantation
Mass Spectrometry allied with in-vivo generation of activated alloreactive T cell populations and tetramer screening facilitates the identification of endogenous peptides that are directly recognised in complex with allogeneic Major Histocompatibility ...
Alexandra E. Hill, Eric T. Son, Moumita Paul-Heng, Chuanmin Wang, Shivanjali Ratnaseelan, Martina Denkova, Pouya Faridi, Asolina Braun, Anthony W. Purcell, Nicole A. Mifsud, Alexandra F. Sharland   +10 more
doaj   +1 more source

Author response: A moonlighting function of a chitin polysaccharide monooxygenase, CWR-1, in Neurospora crassa allorecognition

, 2022
Tyler C. Detomasi, Adriana M. Rico-Ramírez, Richard I. Sayler, A. Pedro Gonçalves, Michael A. Marletta, N. Louise Glass   +5 more
openalex   +1 more source