Full-length nuclear receptor allosteric regulation [PDF]
Journal of Lipid Research, 2023 Nuclear receptors are a superfamily of transcription factors regulated by a wide range of lipids that include phospholipids, fatty acids, heme-based metabolites, and cholesterol-based steroids. Encoded as classic two-domain modular transcription factors,
Woong Jae Choi +2 more
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Insights into the Allosteric Regulation of Human Hsp90 Revealed by NMR Spectroscopy [PDF]
BiomoleculesHuman heat shock protein 90 (Hsp90) is one of the most important chaperones that play a role in the late stages of protein folding. Errors in the process of the chaperone cycle can lead to diseases such as cancer and neurodegenerative diseases. Therefore,
Tjaša Goričan +1 more
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Filamentation modulates allosteric regulation of PRPS
eLife, 2022 Phosphoribosyl pyrophosphate (PRPP) is a key intermediate in the biosynthesis of purine and pyrimidine nucleotides, histidine, tryptophan, and cofactors NAD and NADP.
Huan-Huan Hu +9 more
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Allosteric regulation of kinase activity [PDF]
eLifeThe articles in this special issue highlight how modern cellular, biochemical, biophysical and computational techniques are allowing deeper and more detailed studies of allosteric kinase regulation.
Amy H Andreotti, Volker Dötsch
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Deciphering the allosteric regulation of mycobacterial inosine-5′-monophosphate dehydrogenase [PDF]
Nature CommunicationsAllosteric regulation of inosine 5′-monophosphate dehydrogenase (IMPDH), an essential enzyme of purine metabolism, contributes to the homeostasis of adenine and guanine nucleotides. However, the precise molecular mechanism of IMPDH regulation in bacteria
Ondřej Bulvas +8 more
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Allosteric regulation of epigenetic modifying enzymes [PDF]
Current Opinion in Chemical Biology, 2017 Epigenetic enzymes including histone modifying enzymes are key regulators of gene expression in normal and disease processes. Many drug development strategies to target histone modifying enzymes have focused on ligands that bind to enzyme active sites, but allosteric pockets offer potentially attractive opportunities for therapeutic development. Recent
Beth E. Zucconi, Philip A. Cole
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Unveiling Allosteric Regulation and Binding Mechanism of BRD9 through Molecular Dynamics Simulations and Markov Modeling [PDF]
MoleculesBromodomain-containing protein 9 (BRD9) is a key player in chromatin remodeling and gene expression regulation, and it is closely associated with the development of various diseases, including cancers.
Bin Wang +5 more
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Allosteric regulation of L-lactate dehydrogenase: Beyond effector-mediated tetramerization. [PDF]
Protein SciCai H +5 more
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Coevolution-based prediction of key allosteric residues for protein function regulation
eLife, 2023 Allostery is fundamental to many biological processes. Due to the distant regulation nature, how allosteric mutations, modifications, and effector binding impact protein function is difficult to forecast.
Juan Xie +4 more
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Prediction and confirmation of a switch-like region within the N-terminal domain of hSIRT1
Biochemistry and Biophysics Reports, 2022 Many proteins display conformational changes resulting from allosteric regulation. Often only a few residues are crucial in conveying these structural and functional allosteric changes.
Angelina T. Huynh +10 more
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