Allosteric regulation of kinase activity [PDF]
The articles in this special issue highlight how modern cellular, biochemical, biophysical and computational techniques are allowing deeper and more detailed studies of allosteric kinase regulation.
Amy H Andreotti, Volker Dötsch
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Filamentation modulates allosteric regulation of PRPS [PDF]
Phosphoribosyl pyrophosphate (PRPP) is a key intermediate in the biosynthesis of purine and pyrimidine nucleotides, histidine, tryptophan, and cofactors NAD and NADP.
Huan-Huan Hu+9 more
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Modeling the contribution of allosteric regulation for flux control in the central carbon metabolism of E. coli [PDF]
Modeling metabolism is fundamental for cell factory design. Central carbon metabolism (CCM) is particularly important as it provides the energy and precursors for other biological processes.
Daniel eMachado+2 more
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Insights into the Allosteric Regulation of Human Hsp90 Revealed by NMR Spectroscopy [PDF]
Human heat shock protein 90 (Hsp90) is one of the most important chaperones that play a role in the late stages of protein folding. Errors in the process of the chaperone cycle can lead to diseases such as cancer and neurodegenerative diseases. Therefore,
Tjaša Goričan+1 more
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Full-length nuclear receptor allosteric regulation [PDF]
Nuclear receptors are a superfamily of transcription factors regulated by a wide range of lipids that include phospholipids, fatty acids, heme-based metabolites, and cholesterol-based steroids. Encoded as classic two-domain modular transcription factors,
Woong Jae Choi+2 more
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Deciphering the allosteric regulation of mycobacterial inosine-5′-monophosphate dehydrogenase [PDF]
Allosteric regulation of inosine 5′-monophosphate dehydrogenase (IMPDH), an essential enzyme of purine metabolism, contributes to the homeostasis of adenine and guanine nucleotides. However, the precise molecular mechanism of IMPDH regulation in bacteria
Ondřej Bulvas+8 more
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Unveiling Allosteric Regulation and Binding Mechanism of BRD9 through Molecular Dynamics Simulations and Markov Modeling [PDF]
Bromodomain-containing protein 9 (BRD9) is a key player in chromatin remodeling and gene expression regulation, and it is closely associated with the development of various diseases, including cancers.
Bin Wang+5 more
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Coevolution-based prediction of key allosteric residues for protein function regulation
Allostery is fundamental to many biological processes. Due to the distant regulation nature, how allosteric mutations, modifications, and effector binding impact protein function is difficult to forecast.
Juan Xie+4 more
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Conformational change associated with allosteric regulation in a protein is ultimately driven by energy transformation. However, little is known about the latter process.
Shizhen Wang+2 more
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Quaternary structure is an essential component that contributes to the sophisticated allosteric regulation mechanism in a key enzyme from Mycobacterium tuberculosis. [PDF]
The first enzyme of the shikimate pathway, 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase (DAH7PS), adopts a range of distinct allosteric regulation mechanisms in different organisms, related to different quaternary assemblies.
Wanting Jiao+3 more
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