Results 11 to 20 of about 63,430 (242)
Hairpin and allosteric regulation in ADAMTS13 [PDF]
Blood, 2019 In this issue of Blood , Muia et al 1 and Zhu et al, 2 using complementary approaches, provide important insights into the structure and function of ADAMTS13 (a disintegrin and metalloproteinase with thrombospondin-1 repeats, member 13), identifying critical structural features and interactions that allosterically regulate its proteolytic activity ...
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The structural basis of allosteric regulation in proteins [PDF]
FEBS Letters, 2009 Allosteric regulation of protein function occurs when the regulatory trigger, such as the binding of a small‐molecule effector or inhibitor, takes place some distance from the protein's, or protein complex's, active site. This distance can be a few Å, or tens of Å.
Fabian Gerick +2 more
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Pathways of allosteric regulation in Hsp70 chaperones [PDF]
Nature Communications, 2015 AbstractCentral to the protein folding activity of Hsp70 chaperones is their ability to interact with protein substrates in an ATP-controlled manner, which relies on allosteric regulation between their nucleotide-binding (NBD) and substrate-binding domains (SBD).
Roman Kityk +4 more
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Structural Basis for Allosteric Regulation of the Monomeric Allosteric Enzyme Human Glucokinase [PDF]
Structure, 2004 Glucokinase is a monomeric enzyme that displays a low affinity for glucose and a sigmoidal saturation curve for its substrate, two properties that are important for its playing the role of a glucose sensor in pancreas and liver. The molecular basis for these two properties is not well understood.
Yasufumi Nagata +4 more
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Allosteric regulation of phenylalanine hydroxylase [PDF]
Archives of Biochemistry and Biophysics, 2012 The liver enzyme phenylalanine hydroxylase is responsible for conversion of excess phenylalanine in the diet to tyrosine. Phenylalanine hydroxylase is activated by phenylalanine; this activation is inhibited by the physiological reducing substrate tetrahydrobiopterin.
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Allosteric regulation of Argonaute proteins by miRNAs [PDF]
Nature Structural & Molecular Biology, 2010 Small interfering RNAs (siRNAs) and microRNAs (miRNAs) bind to Argonaute (AGO) family proteins to form a related set of effector complexes that have diverse roles in post-transcriptional gene regulation throughout the eukaryotic lineage. Here sequence and structural analysis of the MID domain of the AGO proteins identified similarities with a family of
Elizabeth J. Rogers +6 more
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Allosteric regulation of rhomboid intramembrane proteolysis [PDF]
The EMBO Journal, 2014 AbstractProteolysis within the lipid bilayer is poorly understood, in particular the regulation of substrate cleavage. Rhomboids are a family of ubiquitous intramembrane serine proteases that harbour a buried active site and are known to cleave transmembrane substrates with broad specificity.
Elena Arutyunova +5 more
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Markov models for the elucidation of allosteric regulation [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2018 Allosteric regulation refers to the process where the effect of binding of a ligand at one site of a protein is transmitted to another, often distant, functional site. In recent years, it has been demonstrated that allosteric mechanisms can be understood by the conformational ensembles of a protein.
Ushnish Sengupta, Birgit Strodel
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TRAF2 binds to TIFA via a novel motif and contributes to its autophagic degradation
FEBS Letters, EarlyView.TRAF family members couple receptor signalling complexes to downstream outputs, but how they interact with these complexes is not always clear. Here, we show that during ADP‐heptose signalling, TRAF2 binding to TIFA requires two short sequence motifs in the C‐terminal tail of TIFA, which are distinct from the TRAF6 binding motif.
Tom Snelling +4 more
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From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
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