Results 11 to 20 of about 130,849 (328)

Quaternary structure is an essential component that contributes to the sophisticated allosteric regulation mechanism in a key enzyme from Mycobacterium tuberculosis. [PDF]

PLoS ONE, 2017
The first enzyme of the shikimate pathway, 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase (DAH7PS), adopts a range of distinct allosteric regulation mechanisms in different organisms, related to different quaternary assemblies.
Wanting Jiao, Nicola J Blackmore, Ali Reza Nazmi, Emily J Parker   +3 more
doaj   +1 more source

Prospects for the use of allosteric drugs in real-world clinical practice

Реальная клиническая практика: данные и доказательства, 2023
While the clinical validity of the use of allosteric regulation is known, scientists are working on the discovery of new methods for the development of allosteric drugs that can modulate the functions of enzymes, depending on the desired therapeutic ...
I. R. Svechkareva, A. S. Kolbin
doaj   +1 more source

Allosteric Regulation at the Crossroads of New Technologies: Multiscale Modeling, Networks, and Machine Learning

Frontiers in Molecular Biosciences, 2020
Allosteric regulation is a common mechanism employed by complex biomolecular systems for regulation of activity and adaptability in the cellular environment, serving as an effective molecular tool for cellular communication.
Gennady M. Verkhivker, Gennady M. Verkhivker, Steve Agajanian, Guang Hu, Peng Tao   +4 more
doaj   +1 more source

Molecular Structure Underlying the Allosteric Mechanism of Caffeine Detection in Taste Sensor

Chemosensors, 2023
The use of taste sensors with lipid/polymer membranes is one of the methods to evaluate taste. As previously reported, taste sensors can detect non-charged substances such as caffeine by modifying the lipid/polymer membranes with hydroxybenzoic acids ...
Hengwei Xu, Zeyu Zhao, Shunsuke Kimura, Takeshi Onodera, Kiyoshi Toko   +4 more
doaj   +1 more source

Allosteres to regulate neurotransmitter sulfonation [PDF]

Journal of Biological Chemistry, 2019
Catecholamine neurotransmitter levels in the synapses of the brain shape human disposition-cognitive flexibility, aggression, depression, and reward seeking-and manipulating these levels is a major objective of the pharmaceutical industry. Certain neurotransmitters are extensively sulfonated and inactivated by human sulfotransferase 1A3 (SULT1A3).
Kristie, Darrah, Ting, Wang, Ian, Cook, Mary, Cacace, Alexander, Deiters, Thomas S, Leyh   +5 more
openaire   +2 more sources

Computational Analysis of Residue Interaction Networks and Coevolutionary Relationships in the Hsp70 Chaperones: A Community-Hopping Model of Allosteric Regulation and Communication. [PDF]

PLoS Computational Biology, 2017
Allosteric interactions in the Hsp70 proteins are linked with their regulatory mechanisms and cellular functions. Despite significant progress in structural and functional characterization of the Hsp70 proteins fundamental questions concerning modularity
Gabrielle Stetz, Gennady M Verkhivker
doaj   +1 more source

Multiple conformations in solution of the maize C4-phosphoenolpyruvate carboxylase isozyme

Heliyon, 2021
The photosynthetic phosphoenolpyruvate carboxylase isozyme from C4 plants (PEPC-C4) has a complex allosteric regulation, involving positive cooperativity in binding the substrate phosphoenolpyruvate as well as positive and negative allosteric effectors ...
Fátima Barreda-Huerta, Ismael Bustos-Jaimes, Carlos Mújica-Jiménez, Rosario A. Muñoz-Clares   +3 more
doaj   +1 more source

The Allosteric Regulation of Pyruvate Kinase [PDF]

Journal of Biological Chemistry, 2000
Pyruvate kinase (PK) is critical for the regulation of the glycolytic pathway. The regulatory properties of Escherichia coli were investigated by mutating six charged residues involved in interdomain salt bridges (Arg(271), Arg(292), Asp(297), and Lys(413)) and in the binding of the allosteric activator (Lys(382) and Arg(431)).
VALENTINI, GIOVANNA, CHIARELLI, LAURENT, SPERANZA, MARIA LUISA, GALIZZI, ALESSANDRO, MATTEVI, ANDREA, FORTIN R   +5 more
openaire   +4 more sources

Novel allosteric inhibition of phosphoribulokinase identified by ensemble kinetic modeling of Synechocystis sp. PCC 6803 metabolism

Metabolic Engineering Communications, 2020
The present study attempted a computer simulation of the metabolism of a model cyanobacteria, Synechocystis sp. PCC 6803 (PCC 6803) to predict allosteric inhibitions that are likely to occur in photoautotrophic and mixotrophic conditions as well as in a ...
Hiroki Nishiguchi, James Liao, Hiroshi Shimizu, Fumio Matsuda   +3 more
doaj   +1 more source

Activity modulation and allosteric control of a scaffolded DNAzyme using a dynamic DNA nanostructure. [PDF]

, 2016
Recognition of the fundamental importance of allosteric regulation in biology dates back to not long after its discovery in the 1960s. Our ability to rationally engineer this potentially useful property into normally non-allosteric catalysts, however ...
Fan, Chunhai, Huang, Qing, Li, Jiang, Mao, Xiuhai, Pei, Hao, Plaxco, Kevin W, Shi, Jiye, Simon, Anna J   +7 more
core   +1 more source