Results 241 to 250 of about 130,849 (328)

Disarming the Hsp70–Bim Alliance: Small‐Molecule and Peptidic Disruptors of a Chaperone‐Apoptotic Switch in Cancer

ChemistryOpen, EarlyView.
Targeting a nucleotide‐sensitive groove on Hsp70 that binds the Bim BH3 helix, we integrate structures, biophysics, and SAR from peptides, fragments, and phenalene‐dicarbonitrile “wedges.” These disrupt the Hsp70–Bim complex with sub‐µM cellular engagement and in vivo activity while sparing Hsp90/mortalin.
Emadeldin M. Kamel, Mohammed Al‐zharani, Lina M. Alneghery, Noha A. Ahmed, Faris F. Aba Alkhayl, Al Mokhtar Lamsabhi   +5 more
wiley   +1 more source

Conformational Remodeling and Allosteric Regulation Underlying EGFR Mutant-Induced Activation: A Multi-Scale Analysis Using MD, MSMs, and NRI. [PDF]

Int J Mol Sci
Duan H, Zhao DR, Liu MT, Yang LQ, Sang P.   +4 more
europepmc   +1 more source

Crystal Structures of the Global Regulator DasR from Streptomyces coelicolor: Implications for the Allosteric Regulation of GntR/HutC Repressors

, 2016
S.B. Fillenberg, Mario D. Friess, С. Körner, Rainer A. Böckmann, Yves A. Muller   +4 more
openalex   +1 more source

Regulation of Insulin Secretion Through Long‐Chain Fatty Acid Receptors

iNew Medicine, EarlyView.
Stefan Offermanns
wiley   +1 more source

The continuing significance of chiral agrochemicals

Pest Management Science, Volume 81, Issue 4, Page 1697-1716, April 2025.
In the time frame 2018–2023, around 43% of the 35 chiral agrochemicals introduced to the market (herbicides, fungicides, insecticides, acaricides, and nematicides) contain one or more stereogenic centers in the molecule, and almost 69% of them have been marketed as racemic mixtures of enantiomers or stereoisomers.
Peter Jeschke
wiley   +1 more source

Surface Dynamics in Allosteric Regulation of Protein-Protein Interactions: Modulation of Calmodulin Functions by Ca2+

, 2013
Yosef Y. Kuttner, Tal Nagar, Stanislav Engel   +2 more
openalex   +2 more sources

Allosteric regulation of phosphonoacetaldehyde hydrolase by n-butylphosphonic acid [PDF]

, 1991
Catherine Dumora, A. M. LACOSTE, A Cassaigne, Jean‐Pierre Mazat   +3 more
openalex   +1 more source

Dissecting the Structural Features of Folding Asymmetry and Transient Misfolding in a Multidomain PDZ Scaffold

Small Science, EarlyView.
This study reveals how a multidomain protein can misfold through subtle internal frustrations rather than by swapping entire domains. Using Φ‐value analysis, the authors map the structural features that govern folding and misfolding in the X11 PDZ1–PDZ2 scaffold.
Valeria Pennacchietti, Mariana Di Felice, Julian Toso, Lucia Marcocci, Paola Pietrangeli, Eduarda S. Ventura, Francesca Malagrinò, Angelo Toto, Stefano Gianni   +8 more
wiley   +1 more source

Structural basis for allosteric regulation of human phosphofructokinase-1. [PDF]

Nat Commun
Lynch EM, Hansen H, Salay L, Cooper M, Timr S, Kollman JM, Webb BA.   +6 more
europepmc   +1 more source

Design, Mechanisms, and Applications of DNA‐Mediated Dynamically Reconfigurable Plasmonic Gold Nanostructures

Small Methods, EarlyView.
This review provides key principles of designing and synthesizing reconfigurable plasmonic gold nanostructures for generating and controlling physical, chemical, and biological properties and functions. The recent advances in the biological and materials applications of dynamically reconfigurable plasmonic gold nanostructures are also summarized ...
So Young Choi, Jieun Kim, Eun Ho Song, Eunhye Park, Jingrui Wu, Juyeon Yoo, Jwa‐Min Nam   +6 more
wiley   +1 more source