Mutations in the PKM2 exon-10 region are associated with reduced allostery and increased nuclear translocation. [PDF]
, 2019 PKM2 is a key metabolic enzyme central to glucose metabolism and energy expenditure. Multiple stimuli regulate PKM2's activity through allosteric modulation and post-translational modifications.
Chen, Tsan-Jan +11 more
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Prediction and confirmation of a switch-like region within the N-terminal domain of hSIRT1
Biochemistry and Biophysics Reports, 2022 Many proteins display conformational changes resulting from allosteric regulation. Often only a few residues are crucial in conveying these structural and functional allosteric changes.
Angelina T. Huynh +10 more
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Computational modeling of cAMP-dependent protein kinase allostery [PDF]
Proceedings of the Estonian Academy of Sciences, 2023 Allosteric regulation by ATP of peptide binding with a cAMP-dependent protein kinase catalytic subunit was comÂputationally modeled by combining conventional docking analysis and molecular dynamics calculations.
Andrei Izvolski, Aleksei Kuznetsov
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Binding leverage as a molecular basis for allosteric regulation.
PLoS Computational Biology, 2011 Allosteric regulation involves conformational transitions or fluctuations between a few closely related states, caused by the binding of effector molecules.
Simon Mitternacht, Igor N Berezovsky
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Nature Communications, 2021 The allosteric regulation of the bienzyme complex imidazole glycerol phosphate synthase (HisFH) remains to be elucidated. Here, the authors provide structural insights into the dynamic allosteric mechanism by which ligand binding to the cyclase and ...
Jan Philip Wurm +6 more
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Molecular determinants of pH regulation in the cardiac Na+-Ca2+ exchanger. [PDF]
, 2018 The cardiac Na+-Ca2+ exchanger (NCX) plays a critical role in the heart by extruding Ca2+ after each contraction and thus regulates cardiac contractility.
Goldhaber, Joshua I +4 more
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Hairpin and allosteric regulation in ADAMTS13 [PDF]
Blood, 2019 In this issue of Blood , Muia et al 1 and Zhu et al, 2 using complementary approaches, provide important insights into the structure and function of ADAMTS13 (a disintegrin and metalloproteinase with thrombospondin-1 repeats, member 13), identifying critical structural features and interactions that allosterically regulate its proteolytic activity ...
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Chimeric glutamate receptor subunits reveal the transmembrane domain is sufficient for NMDA receptor pore properties but some positive allosteric modulators require additional domains [PDF]
, 2016 NMDA receptors are ligand-gated ion channels that underlie transmission at excitatory synapses and play an important role in regulating synaptic strength and stability.
Huettner, Jmaes E +2 more
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The structural basis of allosteric regulation in proteins [PDF]
FEBS Letters, 2009 Allosteric regulation of protein function occurs when the regulatory trigger, such as the binding of a small‐molecule effector or inhibitor, takes place some distance from the protein's, or protein complex's, active site. This distance can be a few Å, or tens of Å.
Fabian Gerick +2 more
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Discovery of intramolecular signal transduction network based on a new protein dynamics model of energy dissipation. [PDF]
PLoS ONE, 2012 A novel approach to reveal intramolecular signal transduction network is proposed in this work. To this end, a new algorithm of network construction is developed, which is based on a new protein dynamics model of energy dissipation. A key feature of this
Cheng-Wei Ma, Zhi-Long Xiu, An-Ping Zeng
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