Results 31 to 40 of about 19,917 (239)
Cancer Communications, Volume 42, Issue 12, Page 1257-1287, December 2022., 2022 Abstract Clustered regularly interspaced short palindromic repeats‐associated protein (CRISPR/Cas9), an adaptive microbial immune system, has been exploited as a robust, accurate, efficient and programmable method for genome targeting and editing. This innovative and revolutionary technique can play a significant role in animal modeling, in vivo genome
Khaled S. Allemailem +6 more
wiley +1 more source
PLoS ONE, 2014 HCV NS3/4A protein is an attractive therapeutic target responsible for harboring serine protease and RNA helicase activities during the viral replication.
Weiwei Xue +4 more
doaj +1 more source
Dimeric allostery mechanism of the plant circadian clock photoreceptor ZEITLUPE.
PLoS Computational Biology, 2021 In Arabidopsis thaliana, the Light-Oxygen-Voltage (LOV) domain containing protein ZEITLUPE (ZTL) integrates light quality, intensity, and duration into regulation of the circadian clock.
Francesco Trozzi +4 more
doaj +1 more source
Allosteric modulation of G protein-coupled receptor signaling
Frontiers in Endocrinology, 2023 G protein-coupled receptors (GPCRs), the largest family of transmembrane proteins, regulate a wide array of physiological processes in response to extracellular signals. Although these receptors have proven to be the most successful class of drug targets,
Siyuan Shen +6 more
doaj +1 more source
The energy landscape analysis of cancer mutations in protein kinases. [PDF]
PLoS ONE, 2011 The growing interest in quantifying the molecular basis of protein kinase activation and allosteric regulation by cancer mutations has fueled computational studies of allosteric signaling in protein kinases.
Anshuman Dixit, Gennady M Verkhivker
doaj +1 more source
Prediction of protein allosteric signalling pathways and functional residues through paths of optimised propensity [PDF]
arXiv, 2022 Allostery commonly refers to the mechanism that regulates protein activity through the binding of a molecule at a different, usually distal, site from the orthosteric site. The omnipresence of allosteric regulation in nature and its potential for drug design and screening render the study of allostery invaluable.
arxiv
Statistical Mechanics of Allosteric Enzymes [PDF]
Journal Physical Chemistry B 120 (2016) 6021-6037, 2017 The concept of allostery in which macromolecules switch between two different conformations is a central theme in biological processes ranging from gene regulation to cell signaling to enzymology. Allosteric enzymes pervade metabolic processes, yet a simple and unified treatment of the effects of allostery in enzymes has been lacking.
arxiv +1 more source
Real-time observation of ligand-induced allosteric transitions in a PDZ domain [PDF]
Proc. Natl. Acad. Sci. USA 117, 26031-26039 (2020), 2020 While allostery is of paramount importance for protein regulation, the underlying dynamical process of ligand (un)binding at one site, resulting time evolution of the protein structure, and change of the binding affinity at a remote site is not well understood.
arxiv +1 more source
The structural basis of ATP as an allosteric modulator. [PDF]
PLoS Computational Biology, 2014 Adenosine-5'-triphosphate (ATP) is generally regarded as a substrate for energy currency and protein modification. Recent findings uncovered the allosteric function of ATP in cellular signal transduction but little is understood about this critical ...
Shaoyong Lu +6 more
doaj +1 more source
A non-equilibrium dynamic mechanism for the allosteric effect [PDF]
Phys. Rev. Lett. 99, 168103 (2007), 2007 Allosteric regulation is often viewed as thermodynamic in nature. However protein internal motions during an enzymatic reaction cycle can be slow hopping processes over numerous potential barriers. We propose that regulating molecules may function by modifying the nonequilibrium protein dynamics.
arxiv +1 more source