Results 31 to 40 of about 130,849 (328)
Allosteric regulation of rhomboid intramembrane proteolysis [PDF]
The EMBO Journal, 2014 AbstractProteolysis within the lipid bilayer is poorly understood, in particular the regulation of substrate cleavage. Rhomboids are a family of ubiquitous intramembrane serine proteases that harbour a buried active site and are known to cleave transmembrane substrates with broad specificity.
Elena, Arutyunova +5 more
openaire +2 more sources
Binding leverage as a molecular basis for allosteric regulation.
PLoS Computational Biology, 2011 Allosteric regulation involves conformational transitions or fluctuations between a few closely related states, caused by the binding of effector molecules.
Simon Mitternacht, Igor N Berezovsky
doaj +1 more source
Computational modeling of cAMP-dependent protein kinase allostery [PDF]
Proceedings of the Estonian Academy of Sciences, 2023 Allosteric regulation by ATP of peptide binding with a cAMP-dependent protein kinase catalytic subunit was comÂputationally modeled by combining conventional docking analysis and molecular dynamics calculations.
Andrei Izvolski, Aleksei Kuznetsov
doaj +1 more source
Molecular determinants of pH regulation in the cardiac Na+-Ca2+ exchanger. [PDF]
, 2018 The cardiac Na+-Ca2+ exchanger (NCX) plays a critical role in the heart by extruding Ca2+ after each contraction and thus regulates cardiac contractility.
Goldhaber, Joshua I +4 more
core +1 more source
Allosteric regulation of phenylalanine hydroxylase [PDF]
Archives of Biochemistry and Biophysics, 2012 The liver enzyme phenylalanine hydroxylase is responsible for conversion of excess phenylalanine in the diet to tyrosine. Phenylalanine hydroxylase is activated by phenylalanine; this activation is inhibited by the physiological reducing substrate tetrahydrobiopterin.
openaire +2 more sources
Nature Communications, 2021 The allosteric regulation of the bienzyme complex imidazole glycerol phosphate synthase (HisFH) remains to be elucidated. Here, the authors provide structural insights into the dynamic allosteric mechanism by which ligand binding to the cyclase and ...
Jan Philip Wurm +6 more
doaj +1 more source
Structural basis of frizzled 7 activation and allosteric regulation. [PDF]
Nat CommunBous J +7 more
europepmc +3 more sources
Engineering and exploiting synthetic allostery of NanoLuc luciferase
Nature Communications, 2022 Allosteric regulation of proteins allows transduction and interconversion of biochemical signals. Here the authors construct an allosteric version of circular permutated NanoLuc that can be activated by a ligand; they use this to create biosensors to ...
Zhong Guo +10 more
doaj +1 more source
Investigation of Structural Dynamics of Enzymes and Protonation States of Substrates Using Computational Tools. [PDF]
, 2016 This review discusses the use of molecular modeling tools, together with existing experimental findings, to provide a complete atomic-level description of enzyme dynamics and function.
Chang, Chia-En A +3 more
core +2 more sources
PLoS ONE, 2014 HCV NS3/4A protein is an attractive therapeutic target responsible for harboring serine protease and RNA helicase activities during the viral replication.
Weiwei Xue +4 more
doaj +1 more source