Results 31 to 40 of about 67,162 (289)

Engineering and exploiting synthetic allostery of NanoLuc luciferase

Nature Communications, 2022
Allosteric regulation of proteins allows transduction and interconversion of biochemical signals. Here the authors construct an allosteric version of circular permutated NanoLuc that can be activated by a ligand; they use this to create biosensors to ...
Zhong Guo, Rinky D. Parakra, Ying Xiong, Wayne A. Johnston, Patricia Walden, Selvakumar Edwardraja, Shayli Varasteh Moradi, Jacobus P. J. Ungerer, Hui-wang Ai, Jonathan J. Phillips, Kirill Alexandrov   +10 more
doaj   +1 more source

Computational study on the inhibitor binding mode and allosteric regulation mechanism in hepatitis C virus NS3/4A protein.

PLoS ONE, 2014
HCV NS3/4A protein is an attractive therapeutic target responsible for harboring serine protease and RNA helicase activities during the viral replication.
Weiwei Xue, Ying Yang, Xiaoting Wang, Huanxiang Liu, Xiaojun Yao   +4 more
doaj   +1 more source

Discovery of intramolecular signal transduction network based on a new protein dynamics model of energy dissipation. [PDF]

PLoS ONE, 2012
A novel approach to reveal intramolecular signal transduction network is proposed in this work. To this end, a new algorithm of network construction is developed, which is based on a new protein dynamics model of energy dissipation. A key feature of this
Cheng-Wei Ma, Zhi-Long Xiu, An-Ping Zeng
doaj   +1 more source

Autopromotion of K-Ras4B Feedback Activation Through an SOS-Mediated Long-Range Allosteric Effect

Frontiers in Molecular Biosciences, 2022
The Ras-specific guanine nucleotide exchange factors Son of Sevenless (SOS) regulates Ras activation by converting inactive GDP-bound to active GTP-bound states.
Xuan He, Kui Du, Yuanhao Wang, Jigang Fan, Mingyu Li, Duan Ni, Shaoyong Lu, Shaoyong Lu, Xiaolan Bian, Yaqin Liu   +9 more
doaj   +1 more source

The allosteric regulation of pyruvate kinase [PDF]

FEBS Letters, 1996
Crystallographic and mutagenesis studies have unravelled the general features of the allosteric transition mechanism in pyruvate kinase. The enzyme displays a dramatic conformational change in going from the T‐ to the R‐state. All three domains forming each subunit of the tetrameric enzyme undergo simultaneous and concerted rotations, in such a way ...
MATTEVI, ANDREA, VALENTINI, GIOVANNA, BOLOGNESI M.   +2 more
openaire   +3 more sources

Dimeric allostery mechanism of the plant circadian clock photoreceptor ZEITLUPE.

PLoS Computational Biology, 2021
In Arabidopsis thaliana, the Light-Oxygen-Voltage (LOV) domain containing protein ZEITLUPE (ZTL) integrates light quality, intensity, and duration into regulation of the circadian clock.
Francesco Trozzi, Feng Wang, Gennady Verkhivker, Brian D Zoltowski, Peng Tao   +4 more
doaj   +1 more source

Allosteric modulation of G protein-coupled receptor signaling

Frontiers in Endocrinology, 2023
G protein-coupled receptors (GPCRs), the largest family of transmembrane proteins, regulate a wide array of physiological processes in response to extracellular signals. Although these receptors have proven to be the most successful class of drug targets,
Siyuan Shen, Chang Zhao, Chao Wu, Suyue Sun, Ziyan Li, Wei Yan, Zhenhua Shao   +6 more
doaj   +1 more source

Allosteric Regulation of E-Cadherin Adhesion [PDF]

Journal of Biological Chemistry, 2015
Cadherins are transmembrane adhesion proteins that maintain intercellular cohesion in all tissues, and their rapid regulation is essential for organized tissue remodeling. Despite some evidence that cadherin adhesion might be allosterically regulated, testing of this has been hindered by the difficulty of quantifying altered E-cadherin binding affinity
Nitesh, Shashikanth, Yuliya I, Petrova, Seongjin, Park, Jillian, Chekan, Stephanie, Maiden, Martha, Spano, Taekjip, Ha, Barry M, Gumbiner, Deborah E, Leckband   +8 more
openaire   +2 more sources

The energy landscape analysis of cancer mutations in protein kinases. [PDF]

PLoS ONE, 2011
The growing interest in quantifying the molecular basis of protein kinase activation and allosteric regulation by cancer mutations has fueled computational studies of allosteric signaling in protein kinases.
Anshuman Dixit, Gennady M Verkhivker
doaj   +1 more source

Engineering allosteric regulation in protein kinases [PDF]

Science Signaling, 2018
Mutations in conserved surface regions facilitate the regulatory diversity of kinases.
David Pincus, Jai P. Pandey, Zoë A. Feder, Pau Creixell, Orna Resnekov, Kimberly A. Reynolds   +5 more
openaire   +2 more sources