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Aloe‐emodin: A review of its pharmacology, toxicity, and pharmacokinetics
Phytotherapy Research, 2019Aloe‐emodin is a naturally anthraquinone derivative and an active ingredient of Chinese herbs, such as Cassia occidentalis, Rheum palmatum L., Aloe vera, and Polygonum multiflorum Thunb. Emerging evidence suggests that aloe‐emodin exhibits many pharmacological effects, including anticancer, antivirus, anti‐inflammatory, antibacterial, antiparasitic ...
Xiaoxv Dong +6 more
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Metabolic Activation and Cytotoxicity of Aloe-Emodin Mediated by Sulfotransferases
Chemical Research in Toxicology, 2019Aloe-emodin (AE) is a major anthraquinone ingredient of numerous traditional Chinese medicines with a variety of beneficial biological activities in vitro. Previous studies suggested that AE possessed cytotoxicity and genotoxicity. Nevertheless, the mechanisms of the toxic action of AE have not yet been fully clarified.
Ruihong Li +5 more
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Potential Antineoplastic Effects of Aloe-emodin: A Comprehensive Review
The American Journal of Chinese Medicine, 2014Aloe-emodin (AE), a bioactive anthraquinone derived from both Aloe vera and Rheum officinale, has recently been demonstrated to have various pharmacological activities. With the widespread popularity of natural products, such as antineoplastic drugs, AE has attracted much attention due to its remarkable antineoplastic activity on multiple tumor cells ...
Ruie, Chen +5 more
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Remote Loading of Aloe Emodin in Gemini-Based Cationic Liposomes
Langmuir, 2014Anthraquinone compound aloe-emodin (AE) has shown antineoplastic, antibacterial, antiviral, and anti-inflammatory properties and scavenging activity on free radicals. Because of these therapeutic features, AE has been attracting increasing interest and could be applied in the curing of many diseases.
Chiara Giuliani +5 more
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Rhein and Aloe-Emodin Kinetics from Senna Laxatives in Man
Pharmacology, 2008Therapeutic doses of two laxatives (Agiolax® and Sennatin®) were repeatedly administered to 10 healthy volunteers in a two-way change-over design. Blood samples were collected up to 96 h after the first dose, and plasma levels of total aloe-emodin and rhein were determined simultaneously with a sensitive (lower limit of quantification: 0.5 ng aloe ...
G, Krumbiegel, H U, Schulz
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Chemical Reactivity of Aloe-Emodin and Its Hydroxylation Metabolites to Thiols
Chemical Research in Toxicology, 2019Aloe-emodin (AE), an anthraquinone derivative, is a bioactive ingredient isolated from rhubarb which is used to treat inflammatory illnesses in China and many other countries in Asia. AE has shown a wide range of pharmacological effects. Recent studies showed that exposure to AE could cause DNA damage and cytotoxicity.
Xu Wang +8 more
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Aloe emodin decreases the ERK-dependent anticancer activity of cisplatin
Cellular and Molecular Life Sciences, 2005The present study describes the ability of an anthraquinone derivative aloe emodin (AE) to reduce the cytotoxic activity of the platinum(II)-based anticancer agent cisplatin toward murine L929 fibrosarcoma and C6 glioma cell lines. The protective effect of AE was demonstrated by MTT and crystal violet assays for cell viability, and involved supression ...
Mijatović, Sanja +6 more
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Einfache Synthese des (?+)-6-Desoxycarminomycinons aus Aloe-Emodin
Angewandte Chemie International Edition in English, 1983AbstractDas vollständige Manuskript dieser Zuschrift erscheint in: Angew. Chem. Suppl. 1983, 1267.
Karsten Krohn, Burkhard Sarstedt
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Cell-type dependent response of melanoma cells to aloe emodin
Food and Chemical Toxicology, 2012Intrinsic characteristics of melanoma cells such as expression of inducible nitric oxide synthase (iNOS), redox status, and activity of signaling pathways involved in proliferation, differentiation and cell death define the response of the cells to the diverse treatments.
Radović, Julijana M +8 more
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Acitretin and aloe-emodin loaded chitin nanogel for the treatment of psoriasis
European Journal of Pharmaceutics and Biopharmaceutics, 2016The present study focuses on the development of an effective topical nanogel formulation of two anti-psoriatic drugs; Acitretin (Act) and Aloe-emodin (AE) using natural polymer chitin. Simple regeneration chemistry was used to prepare Chitin Nanogel Systems (CNGs). The developed control chitin (CNGs) nanogels, acitretin loaded chitin nanogels (ActCNGs)
G, Divya +4 more
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