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Antagonism of androgen receptor signaling by aloe-emodin
Food and Chemical Toxicology, 2023Over the past decades, androgen receptor (AR) signaling has been a key driver of both primary and recurrent prostate cancer. In this work, aloe-emodin was identified as a novel AR antagonist, effectively inhibiting AR signaling. Firstly, aloe-emodin can inhibit LNCaP cell growth by promoting apoptosis. Then, the results of Western blot and quantitative
Jingqi, Zhao +4 more
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Inhibition of CYP3A4 enhances aloe-emodin induced hepatocyte injury
Toxicology in Vitro, 2022Aloe-emodin (AE) is a natural hydroxyanthraquinone derivative that was found in many medicinal plants and ethnic medicines. AE showed a wide array of pharmacological activities including anticancer, antifungal, laxative, antiviral, and antibacterial effects. However, increasing number of published studies have shown that AE may have some hepatotoxicity
Ying-Huan, Hu +4 more
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Photochemistry and Phototoxicity of Aloe Emodin¶
Photochemistry and Photobiology, 2002Photochemical pathways leading to the phototoxicity of the aloe vera constituent aloe emodin were studied. The results indicate a photochemical mechanism involving singlet oxygen to be the most likely pathway responsible for the observed phototoxicity. Aloe emodin was found to efficiently generate singlet oxygen when irradiated with UV light (phidelta =
Peter, Vath +2 more
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Aloe-emodin alleviates doxorubicin-induced cardiotoxicity via inhibition of ferroptosis
Free Radical Biology and Medicine, 2023Aloe-emodin (AE), a novel ferroptosis inhibitor, alleviates the doxorubicin (DOX)-induced cardiotoxicity in H9c2 rat cardiomyocytes. The inhibition of ferroptosis and the protective effect against cardiotoxicity were evaluated via MTT assay in H9c2 cells.
Ying He +4 more
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Einfache Synthese des (?+)-6-Desoxycarminomycinons aus Aloe-Emodin
Angewandte Chemie International Edition in English, 1983AbstractDas vollständige Manuskript dieser Zuschrift erscheint in: Angew. Chem. Suppl. 1983, 1267.
Karsten Krohn, Burkhard Sarstedt
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Potential Antineoplastic Effects of Aloe-emodin: A Comprehensive Review
The American Journal of Chinese Medicine, 2014Aloe-emodin (AE), a bioactive anthraquinone derived from both Aloe vera and Rheum officinale, has recently been demonstrated to have various pharmacological activities. With the widespread popularity of natural products, such as antineoplastic drugs, AE has attracted much attention due to its remarkable antineoplastic activity on multiple tumor cells ...
Ruie, Chen +5 more
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Evaluation of the anti-angiogenic effect of aloe-emodin
Cellular and Molecular Life Sciences, 2006The present study identified aloe-emodin (AE, a hydroxyanthraquinone from Aloe vera and other plants) as a new anti-angiogenic compound with inhibitory effects in an in vivo angiogenesis assay and evaluates its effects on specific key steps of the angiogenic process.
C, Cárdenas, A R, Quesada, M A, Medina
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Aloe-emodin-induced apoptosis in human gastric carcinoma cells
Food and Chemical Toxicology, 2007The purpose of this study was to investigate the anticancer effect of aloe-emodin, an anthraquinone compound present in the leaves of Aloe vera, on two distinct human gastric carcinoma cell lines, AGS and NCI-N87. We demonstrate that aloe-emodin induced cell death in a dose- and time-dependent manner.
Sheng-Hsuan, Chen +4 more
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