Results 11 to 20 of about 24,353 (199)

Aloe-Emodin Induces Mitochondrial Dysfunction and Pyroptosis by Activation of the Caspase-9/3/Gasdermin E Axis in HeLa Cells

Frontiers in Pharmacology, 2022
Aloe-emodin (1,8-dihydroxy-3-hydroxymethyl-anthraquinone), derived from some Chinese edible medicinal herbs, exerts a potential anticancer activity on various cancer cells, making it a drug candidate for cancer therapy.
Tonghui Li, Tonghui Li, Liuliu Shi, Wenqiang Liu, Xuhao Hu, Yuanjian Hui, Maojun Di, Shen Xue, Yan Zheng, Yan Zheng, Mengjuan Yao, Chen Li, Chen Li, Kun Meng, Kun Meng   +14 more
doaj   +3 more sources

Inhibitory Mechanism of Aloe Emodin on α-Glucosidase and Synergistic Effect with Acarbose [PDF]

Shipin Kexue
In order to investigate the interaction between aloe emodin and α-glucosidase, enzyme kinetics, ultraviolet (UV) spectroscopy, infrared (IR) spectroscopy and fluorescence spectroscopy were employed to investigate the inhibitory mechanism of aloe emodin ...
QIN Chaofeng, LI Jiao, HAO Jingwen, BU Yaqin, LI Sheng, CHEN Naidong
doaj   +3 more sources

Aloe-emodin glycosides of senna leaf

Journal of Pharmacy and Pharmacology, 1966
Abstract A new glucoside has been isolated from senna leaf (Cassia senna L.) and shown to be identical with the aloe-emodin-8-mono-β-D-glucoside recently isolated from Rheum palmatum. This new quinone glucoside is insoluble in water and is present in only small quantities and therefore unlikely to contribute much to the activity of the ...
J W, Fairbairn, A B, Shrestha
openaire   +3 more sources

Antiglycation Activity and HT-29 Cellular Uptake of Aloe-Emodin, Aloin, and Aloe arborescens Leaf Extracts [PDF]

Molecules, 2019
Aloe arborescens is a relevant species largely used in traditional medicine of several countries. In particular, the decoction of leaves is prepared for various medicinal purposes including antidiabetic care. The aim of this research was the study of the
Guglielmina Froldi, Federica Baronchelli, Elisa Marin, Margherita Grison   +3 more
doaj   +2 more sources

In vitro studies on the photobiological properties of aloe emodin and aloin A [PDF]

Free Radical Biology and Medicine, 2003
Plants containing aloin A, aloe emodin, and structurally related anthraquinones have long been used as traditional medicines and in the formulation of retail products such as laxatives, dietary supplements, and cosmetics. Since a recent study indicated that topically applied aloe emodin increases the sensitivity of skin to UV light, we examined the ...
Wamer, Wayne G., Vath, Peter, Falvey, Daniel E.   +2 more
openaire   +4 more sources

Aloe-emodin as drug candidate for cancer therapy

Oncotarget, 2018
As a leading cause of global mortality, cancer frequently cannot be cured due to the development of drug resistance. Therefore, novel drugs are required. Naturally occurring anthraquinones are mostly present in Rumex and Rhamnus species and are of interest because of their structural similarity to anthracyclines as well established anticancer drugs. In
ÖZENVER, NADİRE, DEMİREZER, LÜTFİYE ÖMÜR, EFFERTH, Thomas, SAEED, Mohamed   +3 more
openaire   +5 more sources

Antiplasmodial potential and quantification of aloin and aloe-emodin in Aloe vera collected from different climatic regions of India

BMC Complementary and Alternative Medicine, 2017
Background In this study, Aloe vera samples were collected from different climatic regions of India. Quantitative HPTLC (high performance thin layer chromatography) analysis of important anthraquinones aloin and aloe-emodin and antiplasmodial activity of
Sandeep Kumar, Manila Yadav, Amita Yadav, Pooja Rohilla, Jaya Parkash Yadav   +4 more
doaj   +2 more sources

Aloe emodin disrupts Candida albicans mitochondrial iron homeostasis against its hyphal development and oral candidiasis [PDF]

Applied Microbiology and Biotechnology
Candida albicans, a critical pathogen listed on the WHO fungal priority pathogens list, is a major cause of candidiasis and candidemia, particularly in immunocompromised populations.
Jiawei Shen, Chuanli Zhang, Yifan Lin, Chunfei Zhang, Jingzhi Zhou, Yujie Zhou, Lichen Gou, Ga Liao, Zhuoli Zhu, Lei Cheng, Binyou Liao, Biao Ren   +11 more
doaj   +2 more sources

Aloe-emodin, a hydroxyanthracene derivative, is not genotoxic in an in vivo comet test [PDF]

Regulatory Toxicology and Pharmacology, 2021
Aloe-emodin, one of the molecules belonging to the group of hydroxyanthracene derivatives, was recently described as genotoxic in vivo. Indeed, the EFSA judged that aloe-emodin, together with other similar molecules (emodin and danthron) and extracts from the leaf of Aloe species containing hydroxyanthracene derivatives, could represent a risk factor ...
Corrado L. Galli, Serena Cinelli, Paola Ciliutti, Gloria Melzi, Marina Marinovich   +4 more
openaire   +4 more sources

Aloe emodin promotes mucosal healing by modifying the differentiation fate of enteroendocrine cells via regulating cellular free fatty acid sensitivity [PDF]

Acta Pharmaceutica Sinica B
The proper differentiation and reorganization of the intestinal epithelial cell population is critical to mucosal regeneration post injury. Label retaining cells (LRCs) expressing SRY-box transcription factor 9 (SOX9) promote epithelial repair by ...
Weilian Bao, Jiaren Lyu, Guize Feng, Linfeng Guo, Dian Zhao, Keyuan You, Yang Liu, Haidong Li, Peng Du, Daofeng Chen, Xiaoyan Shen   +10 more
doaj   +2 more sources