Results 161 to 170 of about 27,057 (295)

OSA Initiates Histone Lactylation That Drives PDE4B/FUS/AGT Axis to Pulmonary Hypertension

Cell Proliferation, Volume 59, Issue 5, May 2026.
This study illustrates how chronic intermittent hypoxia (CIH) in obstructive sleep apnea (OSA) leads to hypertension via increased oxidative stress and mitochondrial dysfunction in pulmonary artery smooth muscle cells (PASMCs), causing glycolytic dysregulation. Lactate accumulation enhances histone lactylation, upregulating phosphodiesterase 4B (PDE4B),
Li Yang, Qing Ni, Yan He, Shijie Liu, Lulu Gan, Anni Dai, Yang Hu, Qian Liu, Xueling Yang, Jiqian Li, Yi Tao, Yunyu Li, Mingyue Xu   +12 more
wiley   +1 more source

Antioxidants and Regulation of Antioxidant Enzymes by Cellular Redox Status [PDF]

, 2010
It has been well known that free radicals have numerous detrimental effects in both in vitro and in vivo in biological systems because of their unavoidable and tremendous reactivity against biological macromolecules especially proteins, carbohydrates and
Sadi, Gökhan, Sadi, Özlem
core  

Alpha-lipoic acid attenuates iron-overload-induced structural changes in the liver of the laboratory mouse (Mus musculus)

, 2018
William Sibuor, Fidel Gwala, Jeremiah Munguti, Moses Obimbo   +3 more
openalex   +2 more sources

The influence of alpha-lipoic acid on ovarian follicle growth in induced aging mice [PDF]

, 2023
Isam B. Sharum, Enas O. Hussien, Fadwa Tawfeeq   +2 more
openalex   +1 more source

A Multicenter Trial of an Enhanced Serum Comprised of 13 Plant‐Based Adaptogens Targeting Skin Quality in Females Impacted by Hormonal Decline

Journal of Cosmetic Dermatology, Volume 25, Issue 5, May 2026.
ABSTRACT Objectives To assess the effectiveness and tolerability of a serum comprised of plant‐based adaptogens (MYS‐REV) for visible improvements in skin changes caused by hormonal fluctuations associated with perimenopause and postmenopause in women. Study Designs A 16‐week open‐label multicenter study evaluated the efficacy and tolerability of twice‐
Zoe D. Draelos, Amir Moradi, Amber Smathers   +2 more
wiley   +1 more source

Mitigative Effects of Alpha-lipoic Acid on the Toxicity of Dimethoate in Male Rats

, 2019
Hani M Abdelsalam
openalex   +2 more sources

Skin Glycomics: Unmasking the Role of Glycation End Products in Cutaneous Aging and Dermatology

Journal of Cosmetic Dermatology, Volume 25, Issue 5, May 2026.
ABSTRACT Background Skin aging is a multifactorial process influenced by intrinsic and extrinsic factors. Beyond photoaging and oxidative stress, glycation and advanced glycation end products (AGEs) are increasingly recognized as key drivers of cutaneous senescence.
Diala Haykal
wiley   +1 more source

Identification and Validation of DLD as a Cuproptosis‐Associated Biomarker in Preeclampsia

The FASEB Journal, Volume 40, Issue 8, 30 April 2026.
DLD is identified as a preeclampsia‐associated cuproptosis hub gene by bioinformatics. DLD overexpression inhibits trophoblast proliferation, invasion, and migration, disrupts TCA cycle metabolism, and alters mitochondrial ultrastructure. These findings reveal that DLD may contribute to preeclampsia pathogenesis through cuproptosis.
Shuisen Zheng, Xiaoling Chen, Wanrou Tang, Danlin Yang, Qing Han   +4 more
wiley   +1 more source

Quantification of simvastatin in mice plasma by near-infrared and chemometric analysis of spectral data

Drug Design, Development and Therapy, 2016
Usama A Fahmy Department of Pharmaceutics & Industrial Pharmacy, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia Abstract: Time and cost saving is an essential requirement in pharmacokinetics and bioequivalence studies. The aim
Fahmy UA
doaj  

Effect of alpha-lipoic acid and caffeine-loaded chitosan nanoparticles on obesity and its complications in liver and kidney in rats [PDF]

, 2023
Hussein G. Sawie, Yasser A. Khadrawy, Mayada M. El-Gizawy, Hagar H. Mourad, Enayat A. Omara, Eman N. Hosny   +5 more
openalex   +1 more source