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Experimental Neurology, 2008 The study investigates if alpha-lipoic acid is neuroprotective against chemotherapy induced neurotoxicity, if mitochondrial damage plays a critical role in toxic neurodegenerative cascade, and if neuroprotective effects of alpha-lipoic acid depend on ...
Giuseppe Lauria +2 more
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Alpha lipoic acid for dementia
Cochrane Database of Systematic Reviews, 2002Oxidative processes have been implicated in the pathogenesis of neurodegenerative dementias including Alzheimer's disease. Protecting the central nervous system against these damaging mechanisms may be a useful therapeutic approach. Alpha lipoic acid (ALA) is an endogenous antioxidant that interrupts cellular oxidative processes in both its oxidized ...
Anthony Klugman +3 more
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Alpha lipoic acid intoxicatıon: An adult
The American Journal of Emergency Medicine, 2018Alpha lipoic acid (ALA) is a potent antioxidant used to treat a variety of disorders. Although ALA is considered a very safe supplement and intoxication is very rare, acute high-dose ingestions can cause mortality. In this report, we discuss a very rare case of ALA intoxication to increase awareness of this issue.A 22-year-old female was referred to ...
FEREK EMİR, DUYGU +2 more
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Alpha-lipoic acid as a biological antioxidant
Free Radical Biology and Medicine, 1995alpha-Lipoic acid, which plays an essential role in mitochondrial dehydrogenase reactions, has recently gained considerable attention as an antioxidant. Lipoate, or its reduced form, dihydrolipoate, reacts with reactive oxygen species such as superoxide radicals, hydroxyl radicals, hypochlorous acid, peroxyl radicals, and singlet oxygen.
L, Packer, E H, Witt, H J, Tritschler
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Arbor Clinical Nutrition Updates, 2006
In a nutshellALA is a powerful antioxidant, both water and lipid soluble, that can also regenerate other antioxidants.A range of ‘antioxidant’ and other clinical indications (such as chelating toxic metals) have been tested in small, open trials and/or animal studies.
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In a nutshellALA is a powerful antioxidant, both water and lipid soluble, that can also regenerate other antioxidants.A range of ‘antioxidant’ and other clinical indications (such as chelating toxic metals) have been tested in small, open trials and/or animal studies.
openaire +1 more source
ALSUntangled #79: alpha-lipoic acid
Amyotrophic Lateral Sclerosis and Frontotemporal DegenerationAlpha-lipoic acid (ALA) is a naturally occurring fatty acid. It serves as an essential cofactor for enzymatic reactions in mitochondrial energy production, is a potent antioxidant and has anti-inflammatory effects, which are plausible mechanisms in slowing ALS progression.
Alaina Giacobbe +21 more
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The Netherlands Journal of Medicine, 2010
Background: Neuropathic pain is difficult to treat. We identified those studies in the literature in which the effectiveness of alpha lipoic acid as a treatment for neuropathic pain was evaluated.Methods: Systematic literature review. The databases MEDLINE and EMBASE were searched using the keywords "lipoic acid", "thioctic acid", "diabet*", and the ...
Mijnhout, G. S. +3 more
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Background: Neuropathic pain is difficult to treat. We identified those studies in the literature in which the effectiveness of alpha lipoic acid as a treatment for neuropathic pain was evaluated.Methods: Systematic literature review. The databases MEDLINE and EMBASE were searched using the keywords "lipoic acid", "thioctic acid", "diabet*", and the ...
Mijnhout, G. S. +3 more
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The effects of alpha-lipoic acid on diabetic myopathy
Journal of Endocrinological Investigation, 2017Increased oxidative stress and impaired antioxidant defense are important mechanisms in the pathogenesis of diabetic myopathy. Since diabetes mellitus type 1 decreases muscle regeneration capacity the present study was designed to determine the influence of alpha-lipoic acid (ALA), a potent biological antioxidant, on the process of regeneration of ...
Jurišić Eržen, Dubravka +5 more
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Alpha-lipoic acid in the treatment of diabetic polyneuropathy
Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova, 2018The issues of classification, pathogenesis, pathomorphology and treatment of diabetic polyneuropathy (DPN) are addressed. Pathogenetic mechanisms of the action of alpha-lipoic acid in treatment of DPN are justified. The authors present the results of randomized placebo-controlled trials of alpha-lipoic acid that revealed the high clinical efficacy and ...
E I, Chukanova, A S, Chukanova
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Alpha lipoic acid: a novel treatment for depression
Medical Hypotheses, 2000Insulin resistance has been associated with people diagnosed with depression. Conversely, it has also been documented that diabetics have an increased risk of depression. Evidence suggests that insulin activity plays a role in serotonergic activity by increasing the influx of tryptophan into the brain. This increased influx of tryptophan has been shown
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