Results 81 to 90 of about 3,445,082 (289)

Studying the Effect of Adding Alpha Lipoic Acid to Gabapentin to Improve Nerve Conduction Velocity and Glycemic Control of Patients with Diabetic Neuropathy (Sample of Iraqi population)

Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2020
Diabetic neuropathy (DN) is the most common chronic complication of diabetes mellitus. Hyperglycemia-induced oxidative stress induces programmed cell death of nerves, which contributes to the pathology of Diabetic neuropathy. Many clinical trials depend
Rusul AbdulKareem Hadi, Mohammed Mahmood Mohammed, Isam Noori salman   +2 more
doaj   +1 more source

Alpha‐lipoic acid downregulates TRPV1 receptor via NF‐κB and attenuates neuropathic pain in rats with diabetes

CNS Neuroscience & Therapeutics, 2020
Painful diabetic neuropathy (PDN) is a refractory complication of diabetes. The study aimed to investigate the role of α‐lipoic acid (ALA) on the regulation of transient receptor potential vanilloid‐1 (TRPV1) in dorsal root ganglion (DRG) neurons of rats
Bing-yu Zhang, Yilian Zhang, Qian Sun, Ping-An Zhang, Xixi Wang, Guang-Yin Xu, Ji Hu, Hong-Hong Zhang   +7 more
semanticscholar   +1 more source

Dietary Alpha-Lipoic Acid Alters Piglet Neurodevelopment [PDF]

Frontiers in Pediatrics, 2016
Alpha-lipoic acid (a-LA) is an antioxidant shown to ameliorate age-associated impairments of brain and cardiovascular function. Human milk is known to have high antioxidant capacity; however, the role of antioxidants in the developing brain is largely uncharacterized.
Austin T Mudd, Austin T Mudd, Rosaline V Waworuntu, Brian M Berg, Brian M Berg, Ryan N Dilger, Ryan N Dilger, Ryan N Dilger   +7 more
openaire   +3 more sources

Chemical Bond‐Orchestrated Energy Depletion to Augment Lung Cancer Chemo‐Immunotherapy

Advanced Science, EarlyView.
This study grafted dichloroacetic acid (DCA) into perylenediimide (PDI) skeleton via ionic or covalent bond to create novel metabolic agent PDIC‐AC and PDIC‐NAC, explicitly elaborated the underlying energy metabolism and therapeutic mechanism, and developed a promising strategy for energy metabolism‐targeting chemo‐immunotherapy by chemical bond ...
Xuejie Zhao, Yuting Liu, Xiao Huang, Liwen Zhao, Chunli Li, Yongwei Huang   +5 more
wiley   +1 more source

Lactobacillus‐Loaded Bioadhesive Hydrogel with Prolonged Retention and Microenvironmental Remodeling for Endometrial Repair and Fertility Restoration

Advanced Science, EarlyView.
A bioactive adhesive hydrogel capable of long‐term uterine retention (>14 days) and local microenvironment modulation is developed by straightforward integration of α‐lipoic acid, L‐arginine, tannic acid, and Lactobacillus johnsonii, which can markedly enhance endometrial repair and restore fertility in a rat model of endometrial injury.
Lifa Chen, Hui Zhou, Yifei Li, Yi Liang, Yifan Zhang, Huiyu Huang, Qiuxian Xie, Youchen Tang, Huixia Ye, Yu Zhang   +9 more
wiley   +1 more source

Efficacy of the R(+)-enantiomer of alpha-lipoic acid in clinical practice

Mìžnarodnij Endokrinologìčnij Žurnal, 2021
The article presents current data from the scientific medical literature on the effective use of the R(+)-enantiomer of α-lipoic acid in various pathological conditions.
N.О. Kravchun, I.P. Dunaieva
doaj   +1 more source

Mitigation of Radiation-induced Pneumonitis and Lung Fibrosis using Alpha-lipoic Acid and Resveratrol

Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 2020
Background: Lung is a radiosensitive organ. Studies have shown that exposure of the lung to acute and high doses of radiation following inhalation of radioactive agents or an accidental radiological event may lead to pneumonitis and fibrosis, which are ...

semanticscholar   +1 more source

The effects of lipoic acid on rat submandibular salivary gland in valproic acid induced oxidative stress [PDF]

576-583Valproic acid (VA), an anticonvulsant drug, has been associated with various toxic effects, primarily through the induction of oxidative stress.
Veli Ustundag, Unsal, Ipekci, Hazal, Alev-Tuzuner, Burcin, Yanardag, Refiye, Tunali-Akbay, Tugba, Akyuz, Serap, Türkyılmaz-Mutlu, İsmet Burcu, Emekli-Alturfan, Ebru, Tunalı-Akbay, Tuğba, Üstündağ, Ünsal Veli, Ahmad, Sarfraz, Yarat, Aysen, Burcu Turkyilmaz-Mutlu, Ismet   +12 more
core   +1 more source

DLST Succinylation‐Mediated Mitochondrial Metabolic Remodeling and Cuproptosis Resistance Promote Malignant Progression of Lung Adenocarcinoma

Advanced Science, EarlyView.
The DLST K409 succinylation mediated by CPT1A promotes OXPHOS and redox homeostasis through regulating enzyme activity, thereby promoting the malignant progression of LUAD. Notably, the succinylation of DLST can enhance the cuproptosis resistance by inhibiting its lipoylation.
Xuanxuan Li, Peijun Zhou, Xingzhi Peng, Qixin Liu, Wenhui Zeng, Rui Wang, Liangfang Shen, Jinwu Peng, Qin Zhou, Lifang Yang   +9 more
wiley   +1 more source

Efficacy and Safety of the Combination of Superoxide Dismutase, Alpha Lipoic Acid, Vitamin B12, and Carnitine for 12 Months in Patients with Diabetic Neuropathy

Nutrients, 2020
Aim: To investigate the efficacy of Superoxide Dismutase, Alpha Lipoic Acid, Acetyl L-Carnitine, and Vitamin B12 (B12) in one tablet in Diabetic Neuropathy (DN).
T. Didangelos, E. Karlafti, Evangelia Kotzakioulafi, Zisis Kontoninas, Charalampos Margaritidis, P. Giannoulaki, K. Kantartzis   +6 more
semanticscholar   +1 more source