Alpha-lipoic acid drugs in the treatment of diabetic neuropathy
Медицинский совет, 2014 Diabetic neuropathy is the most common complication of diabetes mellitus. Among the large number of drugs used as symptomatic therapy to reduce its manifestations, alpha-lipoic acid medications are specific for providing pathogenic effect on many ...
L. Y. Morgunov
doaj +1 more source
The Evolving Pharmacotherapeutic Landscape for the Treatment of Sickle Cell Disease. [PDF]
, 2020 Sickle cell disease (SCD) is an extremely heterogeneous disease that has been associated with global morbidity and early mortality. More effective and inexpensive therapies are needed.
Ballas, Samir K
core +1 more source
alpha-lipoic acid suppresses 6-hydroxydoparnine-induced ROS generation and apoptosis through the stimulation of glutathione synthesis but not by the expression of heme oxygenase-1 [PDF]
, 2008 We previously reported that the generation of reactive oxygen species (ROS) is the initial event in cell death induced by 6-hydroxydopamine (6-OHDA), an experimental model of Parkinsonism.
Akagi, Reiko +9 more
core +1 more source
Advanced Science, EarlyView.ABSTRACT Advancements in tissue engineering have revolutionized therapeutic paradigms for diabetic tissue defects; however, the lack of applicable scaffold containing various bioactive substance aggregates remained a critical bottleneck hindering satisfactory repair effect.
Tao Wang +8 more
wiley +1 more source
The use of rosuvastatin and alpha lipoic acid in patients with unstable angina
Acta Medica Leopoliensia, 2017 Aim. To investigate the blood lipid profile, indices of functional condition of the liver in patients with unstable angina in the treatment of statins in combination with alpha lipoic acid. Material and Methods.
E.H. Zaremba +3 more
doaj +1 more source
The Effect of Alpha Lipoic Acid in Preventing Atherosclerosis Lesion on the Abdominal Aorta of Diabetes Mellitus Type 2 Rats [PDF]
, 2017 Various studies have studied the clinical use of alpha-lipoic acid (ALA) for treating diabetic complications. The protective effect of lipoic acid in atherosclerosis induced by diabetes mellitus type 2 (DM type 2) still needs further ...
ismawati, I. (Ismawati) +1 more
core
In Vivo Anti-inflammatory Activity of Lipoic Acid Derivatives in Mice [PDF]
, 2013 Background: In mammals lipoic acid (LA) and its reduced form dihydrolipoic acid (DHLA) function as cofactors for multienzymatic complexes catalyzing the decarboxylation of α-ketoacids.
Anna Bilska-Wilkosz +10 more
core +1 more source
Advanced Science, EarlyView.This work identifies M1 macrophage‐mediated inflammation as a key driver of BMSC senescence and bone microstructural deterioration at the enthesis. A tissue‐adhesive hydrogel delivering senomorphic small extracellular vesicles suppresses this inflammatory‐senescent cascade and enhances BMSC resilience by inhibiting the cGAS‐STING‐NF‐κB pathway.
Lingzhi Kong +8 more
wiley +1 more source
Antioxidative effects of α-lipoic acid in the brain, liver and kidneys in selected mouse organs exposed to zymosan [PDF]
, 2015 This study investigated the role of exogenous α-lipoic acid (ALA) in the inflammation caused by zymosan application. Seventy-two adult male white mice were divided into twelve groups: three control groups, three Zymosan groups, three ALA groups and three
Dziubek, Karol +4 more
core +1 more source
Clinical, biochemical, and genetic spectrum of seven patients with NFU1 deficiency [PDF]
, 2015 Disorders of the mitochondrial energy metabolism are clinically and genetically heterogeneous. An increasingly recognized subgroup is caused by defective mitochondrial iron-sulfur (Fe-S) cluster biosynthesis, with defects in 13 genes being linked to ...
Angela eHagendorff +26 more
core +3 more sources