Results 101 to 110 of about 16,063 (220)

Synaptic Deficits Are Rescued in the p25/Cdk5 Model of Neurodegeneration by the Reduction of β-Secretase (BACE1) [PDF]

open access: yes, 2011
Alzheimer's disease (AD) is the most common cause of dementia, and is characterized by memory loss and cognitive decline, as well as amyloid β (Aβ) accumulation, and progressive neurodegeneration.
Gao, Jun   +5 more
core   +3 more sources

Investigating the Interactions Between Protocadherin-19 and Ryk and its Effect on Neurogenesis [PDF]

open access: yes, 2016
Protocadherins are a large, diverse family of neural cell adhesion proteins, but their functions are not understood. Mutations or in several protocadherins have been associated with neurological disorders.
Liebau, Brandon
core  

Elevated serum HER‐2 predicts poor prognosis in breast cancer and is correlated to ADAM10 expression

open access: yesCancer Medicine, 2019
Human epidermal growth factor receptor‐2 (HER‐2) overexpression in breast tumor tissues is associated with a poor prognosis but may benefit from treatment with trastuzumab.
Hui Zheng   +12 more
doaj   +1 more source

Neuroprotective role of epigallocatechin-3-gallate, albeginin and melanoxetin in alzheimer's disease

open access: yesPhytomedicine Plus
Background: Alzheimer's disease (AD) is a heterogeneous and progressive neurodegenerative disorder characterized by cognitive impairment and behavioral disturbances.
Arif Malik   +14 more
doaj   +1 more source

Alpha-lipoic acid alleviates cognitive deficits in transgenic APP23/PS45 mice through a mitophagy-mediated increase in ADAM10 α-secretase cleavage of APP

open access: yesAlzheimer’s Research & Therapy
Background Alpha-lipoic acid (ALA) has a neuroprotective effect on neurodegenerative diseases. In the clinic, ALA can improve cognitive impairments in patients with Alzheimer’s disease (AD) and other dementias.
Jie Zhang   +8 more
doaj   +1 more source

Implications of cholesterol and cholesterol-lowering therapy in Alzheimer s disease [PDF]

open access: yes, 2007
BACKGROUND: Alzheimer s disease (AD) is a severe neurodegenerative disease that mainly afflicts elderly persons, with a characteristic progressive decline of cognitive functions and dementia.
Famer, Daniel
core  

Is anti-cholinesterase therapy of Alzheimer's disease delaying progression? [PDF]

open access: yes, 2018
During the last decade, a systematic effort to develop a pharmacological treatment for Alzheimer's disease (AD) resulted in three drugs being registered for the first time in the US and Europe.
Giacobini, E.
core  

Genetic and molecular markers of cortical brain biopsy in idiopathic normal pressure Hydrocephalus: A scoping review

open access: yesInterdisciplinary Neurosurgery
Introduction: Idiopathic normal pressure hydrocephalus (iNPH) is a condition classically defined by the triad of gait disturbance, cognitive dysfunction, and urinary incontinence.
James Kelbert   +6 more
doaj   +1 more source

Pathologische Veränderungen im Thalamus in einem Tiermodell für die Alzheimer-Krankheit [PDF]

open access: yes, 2010
Die Akkumulation von β-Amyloid-Plaques und neurofibrillären Tangles, die aus hyperphosphoryliertem Tau-Protein bestehen, sind typische pathologische Veränderungen, welche bei der Alzheimer-Erkrankung (AD ...
Flohr, Johann-Christian Antonius
core  

Putative long range mossy fiber sprouting and regional cytochrome c oxidase alteration in the hippocampus of patients with mesial temporal lobe epilepsy

open access: yesScientific Reports
Mesial temporal lobe epilepsy (MTLE) is known as a distributed network disorder, and regional neuroanatomical changes may significantly contribute to aberrant network formation.
Tian Tu   +13 more
doaj   +1 more source
medicine
alzheimer’s disease
amyloid precursor protein
alzheimer's disease
adam10
app
beta-secretase
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