Results 171 to 180 of about 16,063 (220)
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A closer look at alpha-secretase.
Current Alzheimer research, 2008Accumulation of amyloid beta-peptides (Abeta) in the brain is believed to contribute to the development of Alzheimer disease (AD). Abeta, a 40-42 amino acid-comprising proteolytical fragment of the amyloid precursor protein (APP), is released from APP by sequential cleavages via beta- and gamma-secretases.
Bruno, Vincent +4 more
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The alpha secretase ADAM10: A metalloprotease with multiple functions in the brain
Progress in Neurobiology, 2015Proteins belonging to the 'A Disintegrin And Metalloproteinase' (ADAM) family are membrane-anchored proteases that are able to cleave the extracellular domains of several membrane-bound proteins in a process known as 'ectodomain shedding'. In the central nervous system, ADAM10 has attracted the most attention, since it was described as the amyloid ...
Saftig, Paul, Lichtenthaler, Stefan
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Alpha-secretase inhibition reduces human glioblastoma stem cell growth in vitro and in vivo by inhibiting Notch [PDF]
Neuro-Oncology, 2012 The Notch pathway is dysregulated and a potential target in glioblastoma multiforme (GBM). Currently available Notch inhibitors block γ-secretase, which is necessary for Notch processing. However, Notch is first cleaved by α-secretase outside the plasma membrane, via a disintegrin and metalloproteinase-10 and -17.
Olga Mykhaylyk +2 more
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Journal of Alzheimer's Disease, 2006
Development of therapeutics begins with delineating the precise disease pathology along with a reasonable understanding of the sequence of events responsible for the development of disease, or disease pathogenesis. For Alzheimer's disease (AD), the classical pathology is now known for quite some time; however, the disease pathogenesis has eluded our ...
Van Broeckhoven, Christine +1 more
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Development of therapeutics begins with delineating the precise disease pathology along with a reasonable understanding of the sequence of events responsible for the development of disease, or disease pathogenesis. For Alzheimer's disease (AD), the classical pathology is now known for quite some time; however, the disease pathogenesis has eluded our ...
Van Broeckhoven, Christine +1 more
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Alpha-Secretase As a Therapeutic Target
Current Alzheimer Research, 2007In the non-amyloidogenic pathway the alpha-secretase cleaves the amyloid precursor protein (APP) within the sequence of Abeta-peptides and precludes their formation. In addition, alpha-secretase cleavage releases an N-terminal extracellular domain with neurotrophic and neuroprotective properties.
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Alzheimer's & Dementia, 2023
AbstractBackgroundAD (Alzheimer’s disease) is a progressive neurodegenerative disease characterized by extensive neuronal losses and deposits of neurofibrillary tangles and senile plaques. Patients with T2DM (type 2 diabetes mellitus) have structural brain changes and cognitive impairment, with a high risk of developing AD.
Danielle dos Santos Maia Salheb de Oliveira +2 more
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AbstractBackgroundAD (Alzheimer’s disease) is a progressive neurodegenerative disease characterized by extensive neuronal losses and deposits of neurofibrillary tangles and senile plaques. Patients with T2DM (type 2 diabetes mellitus) have structural brain changes and cognitive impairment, with a high risk of developing AD.
Danielle dos Santos Maia Salheb de Oliveira +2 more
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Biochemical and Biophysical Research Communications, 2017
Breast cancer affects one in eight women throughout the course of their lifetime creating a demand for novel prevention strategies against this disease. The Notch signaling pathway is often aberrantly activated in human malignancies including breast cancer.
Violet A, Kiesel, Silvia D, Stan
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Breast cancer affects one in eight women throughout the course of their lifetime creating a demand for novel prevention strategies against this disease. The Notch signaling pathway is often aberrantly activated in human malignancies including breast cancer.
Violet A, Kiesel, Silvia D, Stan
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Phytomedicine, 2015
Alzheimer's disease represents one of the main neurological disorders in the aging population. Treatment options so far are only of symptomatic nature and efforts in developing disease modifying drugs by targeting amyloid beta peptide-generating enzymes remain fruitless in the majority of human studies.
Florian, Schuck +7 more
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Alzheimer's disease represents one of the main neurological disorders in the aging population. Treatment options so far are only of symptomatic nature and efforts in developing disease modifying drugs by targeting amyloid beta peptide-generating enzymes remain fruitless in the majority of human studies.
Florian, Schuck +7 more
openaire +2 more sources
Therapeutic targeting of the alpha-secretase pathway to treat Alzheimer's disease.
Discovery medicine, 2010Alzheimer's disease (AD) is a progressive and degenerative disorder pathophysiologically characterized by the accumulation of beta-amyloid peptides (A-beta) in the brain. A-beta is indicated to be the primary agent in the pathogenesis of AD. A-beta is generated from the amyloid precursor protein (APP) via two proteolytic enzymes, beta- and gamma ...
Can, Zhang, Aleister J, Saunders
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