Results 181 to 190 of about 16,063 (220)

SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10.

Cell, 2010
A hallmark of Alzheimer's disease (AD) is the accumulation of plaques of Abeta 1-40 and 1-42 peptides, which result from the sequential cleavage of APP by the beta and gamma-secretases. The production of Abeta peptides is avoided by alternate cleavage of APP by the alpha and gamma-secretases.
Gizem, Donmez, Diana, Wang, Dena E, Cohen, Leonard, Guarente   +3 more
openaire   +1 more source

Regulation of alpha-secretase ADAM10 expression and activity

Experimental Brain Research, 2011
The amyloid precursor protein (APP) has a pivotal role in pathogenesis of Alzheimer's disease (AD) via its beta- and gamma-secretase-derived cleavage products--the A-beta peptides. An alternative processing pathway provided by the alpha-secretase prevents formation of those toxic peptides and gives rise to the neurotrophic and neuroprotective cleavage ...
Kristina, Endres, Falk, Fahrenholz
openaire   +2 more sources

Protein kinase C epsilon suppresses Abeta production and promotes activation of alpha-secretase.

Biochemical and biophysical research communications, 2001
Deposition of plaques containing Abeta is considered important in the pathogenesis of Alzheimer's disease. Phorbol esters that activate protein kinase C (PKC) promote alpha-secretase-mediated processing of the beta amyloid precursor protein (APP), which generally reduces formation of Abeta.
G, Zhu, D, Wang, Y H, Lin, T, McMahon, E H, Koo, R O, Messing   +5 more
openaire   +1 more source

Alpha-Secretase Cleavage of the Amyloid Precursor Protein: Proteolysis Regulated by Signaling Pathways and Protein Trafficking

Current Alzheimer Research, 2012
α-secretase is the name for a metalloprotease activity, which is assumed to play a key role in the prevention of the molecular mechanisms underlying Alzheimer's disease (AD). Proteases similar to α-secretase are essential for a wide range of biological processes, such as cell adhesion and embryonic development.
openaire   +3 more sources

Acitretin, an Enhancer of Alpha-Secretase Expression, Crosses the Blood-Brain Barrier and Is Not Eliminated by P-Glycoprotein

Neurodegenerative Diseases, 2012
<i>Background:</i> ADAM10 (a disintegrin and metalloproteinase 10) has been demonstrated to act as the main physiological α-secretase. Enzymatic activity of the α-secretase on the one hand prevents the formation of toxic Aβ peptides and on the other hand promotes the secretion of a neurotrophic and neuroprotective amyloid precursor protein ...
David, Holthoewer, Kristina, Endres, Florian, Schuck, Christoph, Hiemke, Ulrich, Schmitt, Falk, Fahrenholz   +5 more
openaire   +2 more sources

Levels of beta-secretase BACE and alpha-secretase ADAM10 mRNAs in Alzheimer hippocampus.

Neuroreport, 2002
The amyloid cascade hypothesis suggests that amyloid precursor protein (APP) proteolytic processing is a key event in the pathogenesis of Alzheimer's disease (AD). The enzymes beta-site APP cleaving enzyme (BACE) and A disintegrin and metalloproteinase 10 (ADAM10) play an important role in APP proteolysis.
GATTA LB, ALBERTINI A, RAVID R, FINAZZI, Dario   +3 more
openaire   +2 more sources

Part-time alpha-secretases: the functional biology of ADAM 9, 10 and 17.

Current Alzheimer research, 2008
Disintegrin metalloproteases of the ADAM family form a large (at present > 40 members in mammals) family of multidomain membrane proteins that in their ectodomain combine a cystein-rich, disintegrin and a zinc metalloprotease domain. Via their metalloprotease domain, ADAMs are often implicated in ectodomain shedding, either to release e.g.
Miriam, Deuss, Karina, Reiss, Dieter, Hartmann   +2 more
openaire   +1 more source

[Effect of an inhibitor of alpha-secretase metabolizing amyloid precursor protein on memory in rats].

Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova, 2006
Intracortical administration of 10(-4) M batimastat, a specific inhibitor of one of metalloproteinases metabolizing amyloid precursor protein, namely alpha-secretase, to adult rats resulted in a decrease in the number of correct runs in a one-level 8-arm maze down to 92.78 +/- 1.03% of the control values (p < 0.01) already 60 min after an injection ...
N M, Dubrovskaia, N N, Nalivaeva, A J, Turner, I A, Zhuravin   +3 more
openaire   +1 more source

The neuropeptide PACAP promotes the alpha-secretase pathway for processing the Alzheimer amyloid precursor protein.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2006
The neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) has neurotrophic as well as anti-apoptotic properties and is involved in learning and memory processes. Its specific G protein-coupled receptor PAC1 is expressed in several central nervous system (CNS) regions, including the hippocampal formation. Here we examined the effect of
Elzbieta, Kojro, Rolf, Postina, Corinna, Buro, Christoph, Meiringer, Katja, Gehrig-Burger, Falk, Fahrenholz   +5 more
openaire   +1 more source

[S2‐01‐01]: Alpha‐secretase as a therapeutic target

Alzheimer's & Dementia, 2005
Falk Fahrenholz, Rolf Postina, Kristina Endres, Claudia Prinzen, Elzbieta Kojro   +4 more
openaire   +1 more source