Frontiers in Pharmacology, 2019 Alpha7 nicotinic acetylcholine receptors (nAChRs) play an important role in learning and memory and are promising targets for pharmacological cognitive enhancement.
Zsolt Kristóf Bali, Istvan Hernadi
exaly +4 more sources
Nicotine improves probabilistic reward learning in wildtype but not alpha7 nAChR null mutants, yet alpha7 nAChR agonists do not improve probabilistic learning [PDF]
European Neuropsychopharmacology, 2018 Cognitive impairments, e.g., reward learning, are present in various psychiatric disorders and warrant treatment. Improving reward-related learning could synergistically enhance psychosocial treatments and cognition generally. A critical first step is to understand the mechanisms underlying reward learning.
Morgane Milienne-Petiot +2 more
exaly +7 more sources
Nicotinic receptor alpha7 expression identifies a novel hematopoietic progenitor lineage. [PDF]
PLoS ONE, 2013 How inflammatory responses are mechanistically modulated by nicotinic acetylcholine receptors (nAChR), especially by receptors composed of alpha7 (α7) subunits, is poorly defined.
Lorise C Gahring +8 more
doaj +5 more sources
Nicotinic receptor Alpha7 expression during tooth morphogenesis reveals functional pleiotropy. [PDF]
PLoS ONE, 2012 The expression of nicotinic acetylcholine receptor (nAChR) subtype, alpha7, was investigated in the developing teeth of mice that were modified through homologous recombination to express a bi-cistronic IRES-driven tau-enhanced green fluorescent protein (
Scott W Rogers, Lorise C Gahring
doaj +3 more sources
Nicotinic receptor Alpha7 expression during mouse adrenal gland development. [PDF]
PLoS ONE, 2014 The nicotinic acetylcholine receptor alpha 7 (α7) is a ligand-activated ion channel that contributes to a diversity of cellular processes involved in development, neurotransmission and inflammation. In this report the expression of α7 was examined in the
Lorise C Gahring +3 more
doaj +4 more sources
Target identification and validation of the alpha7 nicotinic acetylcholine receptor as a potential therapeutic target in retinal disease [PDF]
Frontiers in Ophthalmology, 2023 The role of acetylcholine (ACh) in visual processing in the mammalian retina has been the focus of research for many decades. Pioneering work on the localization of ACh discovered that the neurotransmitter is synthesized and stored in a distinct ...
David M. Linn
doaj +2 more sources
HIV, smoking, and the brain: a convergence of neurotoxicities [PDF]
AIDS Research and TherapyPurpose of review The purpose of this review is to characterize the combined effects of tobacco smoking and human immunodeficiency virus (HIV) infection in people with HIV (PWH) and identify possible therapeutic targets through shared mechanisms for ...
Benjamin L. Orlinick +1 more
doaj +2 more sources
Characterizing the binding of TC-5619 and encenicline on the alpha7 nicotinic acetylcholine receptor using PET imaging in the pig [PDF]
Frontiers in NeuroimagingThe alpha7 nicotinic acetylcholine receptor (α7-nAChR) has has long been considered a promising therapeutic target for addressing cognitive impairments associated with a spectrum of neurological and psychiatric disorders, including Alzheimer's disease ...
Janus H. Magnussen +11 more
doaj +2 more sources
18 F-ASEM PET/MRI targeting alpha7-nicotinic acetylcholine receptor can reveal skeletal muscle denervation [PDF]
EJNMMI ResearchBackground The increased expression of the nicotinic acetylcholine receptor (nAChR) in muscle denervation is thought to be associated with electrophysiological acetylcholine supersensitivity after nerve injury.
Yong-il Kim +10 more
doaj +2 more sources
Quantification of Proliferating and Mitotically Active Retinal Cells in Mice by Flow Cytometry [PDF]
Bio-ProtocolAdult mammals lack the ability to regenerate retinal neurons after injury. However, in previous studies from this lab, topical application of the selective alpha7 nicotinic acetylcholine receptor (nAChR) agonist, PNU-282987, has been associated with an ...
Hope Vanzo-Sparks +3 more
doaj +2 more sources