Heliyon, 2020 Alpha7 nicotinic acetylcholine receptor (α7nAChR) is one of the main subtypes of nAChRs that modulates various cancer-related properties including proliferative, anti-apoptotic, pro-angiogenic and pro-metastatic activities in most of the cancers. It also
Khalil Hajiasgharzadeh +2 more
exaly +4 more sources
Alpha7 nicotinic receptors as novel therapeutic targets for inflammation-based diseases [PDF]
Cellular and Molecular Life Sciences, 2010 In recent years the etiopathology of a number of debilitating diseases such as type 2 diabetes, arthritis, atherosclerosis, psoriasis, asthma, cystic fibrosis, sepsis, and ulcerative colitis has increasingly been linked to runaway cytokine-mediated inflammation.
Rudolf Lucas
exaly +4 more sources
Alpha7 Nicotinic Receptors as Therapeutic Targets in Schizophrenia [PDF]
Nicotine & Tobacco Research, 2018 While current treatments for schizophrenia often provide much relief for positive symptoms such as hallucinations, other symptoms, particularly cognitive deficits, persist and contribute to substantial suffering and reduced quality of life for patients. In searching for novel therapeutic avenues to treat cognitive deficits in schizophrenia, recent work
Jason R, Tregellas, Korey P, Wylie
openaire +3 more sources
The Novel, Nicotinic Alpha7 Receptor Partial Agonist, BMS-933043, Improves Cognition and Sensory Processing in Preclinical Models of Schizophrenia. [PDF]
PLoS ONE, 2016 The development of alpha7 nicotinic acetylcholine receptor agonists is considered a promising approach for the treatment of cognitive symptoms in schizophrenia patients. In the present studies we characterized the novel agent, (2R)-N-(6-(1H-imidazol-1-yl)
Linda J Bristow +22 more
doaj +2 more sources
Alpha7 nicotinic receptors as therapeutic targets for Parkinson's disease [PDF]
Biochemical Pharmacology, 2015 Accumulating evidence suggests that CNS α7 nicotinic acetylcholine receptors (nAChRs) are important targets for the development of therapeutic approaches for Parkinson's disease. This progressive neurodegenerative disorder is characterized by debilitating motor deficits, as well as autonomic problems, cognitive declines, changes in affect and sleep ...
Maryka, Quik +3 more
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Nicotine withdrawal-induced inattention is absent in alpha7 nAChR knockout mice [PDF]
Psychopharmacology, 2017 Smoking is the leading cause of preventable death in the USA, but quit attempts result in withdrawal-induced cognitive dysfunction and predicts relapse. Greater understanding of the neural mechanism(s) underlying these cognitive deficits is required to develop targeted treatments to aid quit attempts.We examined nicotine withdrawal-induced inattention ...
Higa, KK +11 more
openaire +5 more sources
The Expression of the Alpha7 Nicotinic Acetylcholine Receptor and the Effect of Smoking in Curdlan-Administered SKG Mice [PDF]
Biomedicines, 2023 Nicotine, an abundant molecule in tobacco, has immunomodulatory effects on inflammatory diseases, primarily due to the activation of alpha7 nicotinic acetylcholine receptor (α7 nAChR).
Young-Eun Kim +10 more
doaj +2 more sources
The alpha7 nicotinic acetylcholine receptor as a pharmacological target for inflammation [PDF]
British Journal of Pharmacology, 2007 The physiological regulation of the immune system encompasses comprehensive anti‐inflammatory mechanisms that can be harnessed for the treatment of infectious and inflammatory disorders. Recent studies indicate that the vagal nerve, involved in control of heart rate, hormone secretion and gastrointestinal motility, is also an immunomodulator.
W J, de Jonge, L, Ulloa
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Alpha7 Nicotinic Acetylcholine Receptor Is a Target in Pharmacology and Toxicology [PDF]
International Journal of Molecular Sciences, 2012 Alpha7 nicotinic acetylcholine receptor (α7 nAChR) is an important part of the cholinergic nerve system in the brain. Moreover, it is associated with a cholinergic anti-inflammatory pathway in the termination of the parasympathetic nervous system. Antagonists of α7 nAChR are a wide group represented by conotoxin and bungarotoxin.
M. Pohanka
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Cas9- and Cas12a-mediated excision and replacement of the celiac disease-related α-gliadin immunogenic complex in hexaploid wheat. [PDF]
Plant Biotechnol JSummary Celiac disease (CD) is a chronic enteropathy affecting approximately 1% of the global population. Wheat α‐gliadins are a major contributor to the autoimmune response, as they contain one of the most immunogenic peptides, the 33‐mer, along with numerous variants.
Marín-Sanz M +5 more
europepmc +2 more sources