Results 31 to 40 of about 5,528 (200)
The expression of nicotinic receptor alpha7 during cochlear development [PDF]
Brain and Behavior, 2012 AbstractNicotinic acetylcholine receptor alpha7 expression was examined in the developing and adult auditory system using mice that were modified through homologous recombination to coexpress either GFP (alpha7GFP) or Cre (alpha7Cre), respectively.
Rogers, Scott W +2 more
openaire +2 more sources
Frontiers in Immunology, 2020 Nicotine acts as a potent modulator of normal cellular responses through the nicotinic acetylcholine receptor subtype alpha7. In a mouse genetic model of alpha7 receptor dysfunction, alpha7E260A:G, 85 percent of 18 month-old mice exhibit an age ...
Scott W. Rogers +4 more
doaj +1 more source
Characterization of a Bovine Serum Albumin-Derived Pro-Cognitive Peptide (bSAPP): An Orally Active Peptide Alleviates Cognitive Decline in HFD-Fed Mice via CCK Signaling Through the Gut-Brain Axis. [PDF]
FASEB JThe popularity of the Western diet has increased the prevalence of dementia in addition to aging. We found that the digest of bovine serum albumin and a peptide derived from the digest showed an oral pro‐cognitive effect in mice fed a high‐fat diet (HFD). We named the peptide bSAPP (EC50 = 0.01 mg/kg BW). The oral effect of bSAPP was modulated by CCK1R
Zhang B +5 more
europepmc +2 more sources
iMeta, Volume 2, Issue 4, November 2023., 2023 We obtained 72 strains of Latilactobacillus sakei from 120 fermentation and fecal samples across China. In total, 16 strains from different sources were initially screened in an in vitro Caco‐2 model. Subsequently, six strains (four exhibiting effectiveness and two exhibiting ineffectiveness) were selected for further validation in an in vivo colitis ...
Yaru Liu +9 more
wiley +1 more source
The knowns and unknowns of cardiac autoimmunity in viral myocarditis
Reviews in Medical Virology, Volume 33, Issue 6, November 2023., 2023 Abstract Myocarditis can result from various infectious and non‐infectious causes that can lead to dilated cardiomyopathy (DCM) and heart failure. Among the infectious causes, viruses are commonly suspected. But the challenge is our inability to demonstrate infectious viral particles during clinical presentations, partly because by that point, the ...
Kiruthiga Mone, Jay Reddy
wiley +1 more source
Two residues determine nicotinic acetylcholine receptor requirement for RIC‐3
Protein Science, Volume 32, Issue 9, September 2023., 2023 Abstract Nicotinic acetylcholine receptors (N‐AChRs) mediate fast synaptic signaling and are members of the pentameric ligand‐gated ion channel (pLGIC) family. They rely on a network of accessory proteins in vivo for correct formation and transport to the cell surface.
Jennifer D. Noonan, Robin N. Beech
wiley +1 more source
Alpha7 nicotinic acetylcholine receptor: A link between inflammation and neurodegeneration [PDF]
Neuroscience & Biobehavioral Reviews, 2008 Alzheimer's disease (AD) is the leading cause of dementia affecting over 25 million people worldwide. Classical studies focused on the description and characterization of the pathological hallmarks found in AD patients including the neurofibrillary tangles and the amyloid plaques.
Concepcion, Conejero-Goldberg +2 more
openaire +2 more sources
The FASEB Journal, Volume 37, Issue 9, September 2023., 2023 (A) Mice acutely exposed to an obesogenic diet have higher TNFα and Let‐7a, while lower Chrna7 levels in the hypothalamus, as well as the hypothalamic neuronal cells exposed to fatty acids overload. (B) In vitro assays confirmed that Let‐7a can directly regulate Chrna7 levels. (C) When the hypothalamic neuronal cells exposed to fatty acids overload are
Laís A. P. Simino +11 more
wiley +1 more source
Targeted molecular dynamics study of C-loop closure and channel gating in nicotinic receptors. [PDF]
PLoS Computational Biology, 2006 The initial coupling between ligand binding and channel gating in the human alpha7 nicotinic acetylcholine receptor (nAChR) has been investigated with targeted molecular dynamics (TMD) simulation. During the simulation, eight residues at the tip of the C-
Xiaolin Cheng +4 more
doaj +1 more source
Cholinergic pairing with visual activation results in long-term enhancement of visual evoked potentials. [PDF]
PLoS ONE, 2009 Acetylcholine (ACh) contributes to learning processes by modulating cortical plasticity in terms of intensity of neuronal activity and selectivity properties of cortical neurons.
Jun Il Kang, Elvire Vaucher
doaj +1 more source