Results 41 to 50 of about 5,528 (200)

Negative and positive allosteric modulators of the α7 nicotinic acetylcholine receptor regulates the ability of adolescent binge alcohol exposure to enhance adult alcohol consumption

Frontiers in Behavioral Neuroscience, 2023
Rationale and Objectives: Ethanol acts directly on the α7 Nicotinic acetylcholine receptor (α7). Adolescent-binge alcohol exposure (ABAE) produces deleterious consequences during adulthood, and data indicate that the α7 receptor regulates these damaging ...
Zachary A. Rodd, Zachary A. Rodd, H. Scott Swartzwelder, R. Aaron Waeiss, R. Aaron Waeiss, Serhii O. Soloviov, Serhii O. Soloviov, Debomoy K. Lahiri, Debomoy K. Lahiri, Debomoy K. Lahiri, Debomoy K. Lahiri, Debomoy K. Lahiri, Eric A. Engleman, Eric A. Engleman, William A. Truitt, William A. Truitt, Richard L. Bell, Richard L. Bell, Sheketha R. Hauser, Sheketha R. Hauser   +19 more
doaj   +1 more source

A sequence‐based foldability score combined with AlphaFold2 predictions to disentangle the protein order/disorder continuum

Proteins: Structure, Function, and Bioinformatics, Volume 91, Issue 4, Page 466-484, April 2023., 2023
Abstract Order and disorder govern protein functions, but there is a great diversity in disorder, from regions that are—and stay—fully disordered to conditional order. This diversity is still difficult to decipher even though it is encoded in the amino acid sequences.
Apolline Bruley, Tristan Bitard‐Feildel, Isabelle Callebaut, Elodie Duprat   +3 more
wiley   +1 more source

Central Activation of Alpha7 Nicotinic Signaling Attenuates LPS-Induced Neuroinflammation and Sickness Behavior in Adult but Not in Aged Animals

Molecules, 2021
We previously reported that lipopolysaccharide (LPS) challenge caused microglial-mediated neuroinflammation and sickness behavior that was amplified in aged mice.
Elisa Navarro, Diana M. Norden, Paige J. Trojanowski, Jonathan P. Godbout, Manuela G. López   +4 more
doaj   +1 more source

Alpha7 cholinergic‐agonist prevents systemic inflammation and improves survival during resuscitation [PDF]

Journal of Cellular and Molecular Medicine, 2009
AbstractSevere haemorrhage is a common cause of death despite the recent advances in critical care. Conventional resuscitation fluids are designed to re‐establish tissue perfusion, but they fail to prevent inflammatory responses during resuscitation.
Cai, Bolin, Chen, Fei, Ji, Yan, Kiss, Levente, de Jonge, Wouter J., Conejero-Goldberg, Concepcion, Szabo, Csaba, Deitch, Edwin A., Ulloa, Luis   +8 more
openaire   +3 more sources

Neuronal nicotinic alpha7 receptors modulate early neutrophil infiltration to sites of skin inflammation

Journal of Neuroinflammation, 2010
Background A major site of initiation of inflammatory responses upon physical perturbation(s) and infection by invading organisms is the skin. Control of responses in this organ is, in part, modulated by the neuronal nicotinic acetylcholine receptor ...
Osborne Amber V, Gahring Lorise C, Reed Michelle, Rogers Scott W   +3 more
doaj   +1 more source

Pharmacologic activation of cholinergic alpha7 nicotinic receptors mitigates depressive-like behavior in a mouse model of chronic stress

Journal of Neuroinflammation, 2017
BackgroundIt has been shown that chronic stress-induced depression is associated with exaggerated inflammatory response in the brain. Alpha7 nicotinic acetylcholine receptors (α7nAChRs) regulate the cholinergic anti-inflammatory pathway, but the role of ...
Dan Zhao, Xulin Xu, Lin-na Pan, Wei Zhu, Xiaopei Fu, Lian-Jun Guo, Q. Lu, Jian Wang   +7 more
semanticscholar   +1 more source

NAD+ biosynthesis ameliorates a zebrafish model of muscular dystrophy.

PLoS Biology, 2012
Muscular dystrophies are common, currently incurable diseases. A subset of dystrophies result from genetic disruptions in complexes that attach muscle fibers to their surrounding extracellular matrix microenvironment.
Michelle F Goody, Meghan W Kelly, Christine J Reynolds, Andre Khalil, Bryan D Crawford, Clarissa A Henry   +5 more
doaj   +1 more source

Facilitation and inhibition of firing activity and N-methyl-D-aspartate-evoked responses of CA1 hippocampal pyramidal cells by alpha7 nicotinic acetylcholine receptor selective compounds in vivo

Scientific Reports, 2019
Alpha7 nicotinic acetylcholine receptors (nAChRs) are promising novel targets for the treatment of neurocognitive disorders. Although the cognitive enhancer potential of alpha7 nAChR agonists and positive allosteric modulators (PAMs) has been confirmed ...
Z. K. Bali, L. V. Nagy, D. Budai, I. Hernádi   +3 more
semanticscholar   +1 more source

Identification of new bile alcohols, 5 beta-cholestane-3 alpha,7 alpha,24,26-tetrol, 5 beta-cholestane-3 alpha,7 alpha,25,26-tetrol, and 5 beta-cholestane-3 alpha,7 alpha,26,27-tetrol in human gallbladder bile.

Journal of Lipid Research, 1990
The nature of cholestanetetrols present as the glucurono-conjugates in human gallbladder bile was studied. Glucurono-conjugated bile alcohols were isolated by ion exchange chromatography and, after enzymatic hydrolysis, were fractionated by reversed ...
M Une, Y Shinonaga, N Matoba, S Kuroki, K Kihira, T Hoshita   +5 more
doaj   +1 more source

Beneficial impacts of neuromuscular electrical stimulation on muscle structure and function in the zebrafish model of Duchenne muscular dystrophy

eLife, 2022
Neuromuscular electrical stimulation (NMES) allows activation of muscle fibers in the absence of voluntary force generation. NMES could have the potential to promote muscle homeostasis in the context of muscle disease, but the impacts of NMES on diseased
Elisabeth A Kilroy, Amanda C Ignacz, Kaylee L Brann, Claire E Schaffer, Devon Varney, Sarah S Alrowaished, Kodey J Silknitter, Jordan N Miner, Ahmed Almaghasilah, Tashawna L Spellen, Alexandra D Lewis, Karissa Tilbury, Benjamin L King, Joshua B Kelley, Clarissa A Henry   +14 more
doaj   +1 more source