Nicotine Causes Nephrotoxicity through the Induction of NLRP6 Inflammasome and Alpha7 Nicotinic Acetylcholine Receptor [PDF]
Toxics, 2020 Current cigarette smoking is associated with chronic kidney disease (CKD) or death from end-stage renal disease (ESRD). Mainstream cigarette smoke includes over 4000 compounds.
Cai-Mei Zheng +6 more
doaj +7 more sources
The dual role of alpha7 nicotinic acetylcholine receptor in inflammation-associated gastrointestinal cancers [PDF]
Heliyon, 2020 Alpha7 nicotinic acetylcholine receptor (α7nAChR) is one of the main subtypes of nAChRs that modulates various cancer-related properties including proliferative, anti-apoptotic, pro-angiogenic and pro-metastatic activities in most of the cancers. It also
Khalil Hajiasgharzadeh +8 more
doaj +4 more sources
Cognitive Enhancer Effects of Low Memantine Doses Are Facilitated by an Alpha7 Nicotinic Acetylcholine Receptor Agonist in Scopolamine-Induced Amnesia in Rats [PDF]
Frontiers in Pharmacology, 2019 Alpha7 nicotinic acetylcholine receptors (nAChRs) play an important role in learning and memory and are promising targets for pharmacological cognitive enhancement.
Zsolt Kristóf Bali +15 more
doaj +4 more sources
Alpha7 nicotinic acetylcholine receptor mediates chronic nicotine inhalation-induced cardiopulmonary dysfunction. [PDF]
Clin Sci (Lond), 2022 Abstract Cigarette smoking remains the leading modifiable risk factor for cardiopulmonary diseases; however, the effects of nicotine alone on cardiopulmonary function remain largely unknown. Previously, we have shown that chronic nicotine vapor inhalation in mice leads to the development of pulmonary hypertension (PH) with right ...
Whitehead AK +10 more
europepmc +3 more sources
Effect of stimulated platelets in COVID-19 thrombosis: Role of alpha7 nicotinic acetylcholine receptor [PDF]
Frontiers in Cardiovascular Medicine, 2022 Since early 2020, SARS-CoV-2-induced infection resulted in global pandemics with high morbidity, especially in the adult population. COVID-19 is a highly prothrombotic condition associated with subsequent multiorgan failure and lethal outcomes. The exact
Lina Jankauskaite +3 more
doaj +2 more sources
Autophagy is Involved in Neuroprotective Effect of Alpha7 Nicotinic Acetylcholine Receptor on Ischemic Stroke [PDF]
Frontiers in Pharmacology, 2021 The α7 nicotinic acetylcholine receptor (α7nAChR) belongs to the superfamily of cys loop cationic ligand-gated channels, which consists of homogeneous α7 subunits.
Zhe-Qi Xu +7 more
doaj +2 more sources
The Expression of the Alpha7 Nicotinic Acetylcholine Receptor and the Effect of Smoking in Curdlan-Administered SKG Mice [PDF]
Biomedicines, 2023 Nicotine, an abundant molecule in tobacco, has immunomodulatory effects on inflammatory diseases, primarily due to the activation of alpha7 nicotinic acetylcholine receptor (α7 nAChR).
Young-Eun Kim +10 more
doaj +2 more sources
GTS-21, a selective alpha7 nicotinic acetylcholine receptor agonist, ameliorates diabetic nephropathy in Leprdb/db mice [PDF]
Scientific Reports, 2022 Diabetic nephropathy (DN) is a serious complicating factor in human type 2 diabetes mellitus (T2DM), and it commonly results in end-stage renal disease (ESRD) that requires kidney dialysis.
Qinghe Meng +6 more
doaj +2 more sources
Target identification and validation of the alpha7 nicotinic acetylcholine receptor as a potential therapeutic target in retinal disease [PDF]
Frontiers in Ophthalmology, 2023 The role of acetylcholine (ACh) in visual processing in the mammalian retina has been the focus of research for many decades. Pioneering work on the localization of ACh discovered that the neurotransmitter is synthesized and stored in a distinct ...
David M. Linn
doaj +2 more sources
The human alpha7 nicotinic acetylcholine receptor is a host target for the rabies virus glycoprotein [PDF]
Frontiers in Cellular and Infection MicrobiologyThe rabies virus enters the nervous system by interacting with several molecular targets on host cells to modify behavior and trigger receptor-mediated endocytosis of the virion by poorly understood mechanisms.
Brittany C. V. O’Brien +6 more
doaj +2 more sources