Results 131 to 140 of about 2,375 (163)
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Annals of Surgical Oncology, 2011
The objective was to study the mechanism of nicotine-enhanced migration of gastric cancer cells. Long-term cigarette smoking increases the risk of gastric cancer mortality. Tobacco-specific mitogen, nicotine, was reported to correlate with cancer progression on gastric cancer.
Yung-Chang, Lien +8 more
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The objective was to study the mechanism of nicotine-enhanced migration of gastric cancer cells. Long-term cigarette smoking increases the risk of gastric cancer mortality. Tobacco-specific mitogen, nicotine, was reported to correlate with cancer progression on gastric cancer.
Yung-Chang, Lien +8 more
openaire +2 more sources
Schizophrenia and the α7 Nicotinic Acetylcholine Receptor
2007In addition to the devastating symptoms of psychosis, many people with schizophrenia also suffer from cognitive impairment. These cognitive symptoms lead to marked dysfunction and can impact employability, treatment adherence, and social skills. Deficits in P50 auditory gating are associated with attentional impairment and may contribute to cognitive ...
Laura F, Martin, Robert, Freedman
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Alpha7 nicotinic acetylcholine receptor activation attenuated intestine-derived acute lung injury
Journal of Surgical Research, 2016Intestinal ischemia-reperfusion (IIR) could lead to acute lung injury, associated with severe alveolar epithelial cells inflammatory and oxidative injury. Alpha7 nicotinic acetylcholine receptor (α7nAChR) is an essential component of the cholinergic anti-inflammatory pathway. The aim of this study was to investigate the important role of α7nAChR on the
Ye, He +6 more
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Anti-Inflammatory Effect of Alpha7 Nicotinic Acetylcholine Receptor Modulators on BV2 Cells
Neuroimmunomodulation, 2020<b><i>Objective:</i></b> The development of neuroinflammation shares numerous risk factors and involves many complex interactions which contribute to disease pathology. An important cell type in neuroinflammation is the active microglia cell – the resident immune cell of the CNS.
Aripaka, Sanjay S., Mikkelsen, Jens D.
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Fractional Ca2+ current through human neuronal α7 nicotinic acetylcholine receptors
Cell Calcium, 2003The neuronal alpha7 nicotinic acetylcholine (ACh) receptor is believed to be a highly Ca(2+) permeable ligand-gated receptor-channel. However, the contribution of Ca(2+) to cationic current generated by ACh has not yet been directly measured to date.
FUCILE, Sergio +3 more
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Crosstalk between tau and alpha7 nicotinic acetylcholine receptors at the synapse
Alzheimer's & Dementia, 2023AbstractBackgroundThe failure of cholinergic transmission and the increase of amyloid‐β peptide (Aβ) and tau protein are key players in Alzheimer’s disease (AD). The interaction between α7 nicotinic acetylcholine receptors (α7‐nAChRs) and Aβ has been previously investigated, but few studies have focused on the crosstalk between α7‐nAChRs and tau.
Maria Rosaria Tropea +8 more
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Selective alpha7 nicotinic acetylcholine receptor ligands.
Current medicinal chemistry, 2006Neuronal nicotinic acetylcholine receptors (nAChRs) are ligand gated ion channels of broad distribution and structural heterogeneity. Their functional diversity demonstrated involvement in a variety of neuronal processes (e.g., sensory gating and cognitive function) and generated great interest in them as targets for therapeutic intervention in a ...
Anatoly, Mazurov +2 more
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Virtual screening for alpha7 nicotinic acetylcholine receptor for treatment of Alzheimer's disease
Journal of Molecular Graphics and Modelling, 2013Alzheimer's disease (AD) is the most common form of dementia. Although its cause and mechanism of progression are not well understood, various in vitro and in vivo experiments have proved that the decreased activity of the cholinergic neuron is responsible for the memory damage that is observed in these patients.
Shi-Gao, Chen +3 more
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Pharmaceutical Research, 2010
Inflammatory disorders are characterized by the influx of immune cells into the vascular wall of veins and/or arteries in response to stimuli such as oxidized-LDL and various pathogens. These factors stimulate the local production of pro-inflammatory cytokines by macrophages and other cells that promote various inflammatory diseases such as ...
Mario B, Marrero +3 more
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Inflammatory disorders are characterized by the influx of immune cells into the vascular wall of veins and/or arteries in response to stimuli such as oxidized-LDL and various pathogens. These factors stimulate the local production of pro-inflammatory cytokines by macrophages and other cells that promote various inflammatory diseases such as ...
Mario B, Marrero +3 more
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Nicotinic Acetylcholine Receptors and the Roles of the Alpha7 Subunit
2014Nicotinic acetylcholine receptors (nAChR) are members of the Cys-loop superfamily of ligand-gated ion channels that includes glycine, γ-aminobutyric acid (GABAA), and serotonin receptor channels. The members of the family are defined by a similar pentameric structure with five membrane-spanning subunits surrounding a central water-filled, cation ...
Michael Paolini +2 more
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