Results 31 to 40 of about 2,375 (163)

The alpha7 nicotinic acetylcholine receptor as a pharmacological target for inflammation [PDF]

British Journal of Pharmacology, 2007
The physiological regulation of the immune system encompasses comprehensive anti‐inflammatory mechanisms that can be harnessed for the treatment of infectious and inflammatory disorders. Recent studies indicate that the vagal nerve, involved in control of heart rate, hormone secretion and gastrointestinal motility, is also an immunomodulator.
W J, de Jonge, L, Ulloa
openaire   +3 more sources

Human Platelets Express Functional α7-Nicotinic Acetylcholine Receptors [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2011
Objective—Nicotinic acetylcholine receptors, especially α7 (nAChRα7), form Ca2+channels and are expressed on a variety of neuronal and nonneuronal cells. Also, megakaryocytic cells have been shown to contain components of a nonneuronal cholinergic system, including acetylcholine and acetylcholine esterase.
Angelika, Schedel, Sophia, Thornton, Patrick, Schloss, Harald, Klüter, Peter, Bugert   +4 more
openaire   +2 more sources

Hypothalamic α7 nicotinic acetylcholine receptor (α7nAChR) is downregulated by TNFα‐induced Let‐7 overexpression driven by fatty acids

The FASEB Journal, Volume 37, Issue 9, September 2023., 2023
(A) Mice acutely exposed to an obesogenic diet have higher TNFα and Let‐7a, while lower Chrna7 levels in the hypothalamus, as well as the hypothalamic neuronal cells exposed to fatty acids overload. (B) In vitro assays confirmed that Let‐7a can directly regulate Chrna7 levels. (C) When the hypothalamic neuronal cells exposed to fatty acids overload are
Laís A. P. Simino, Mayara N. Baqueiro, Carolina Panzarin, Priscilla K. F. Lopes, Mariana M. Góis, Fernando M. Simabuco, Letícia M. Ignácio‐Souza, Marciane Milanski, Michael G. Ross, Mina Desai, Adriana S. Torsoni, Marcio A. Torsoni   +11 more
wiley   +1 more source

A sequence‐based foldability score combined with AlphaFold2 predictions to disentangle the protein order/disorder continuum

Proteins: Structure, Function, and Bioinformatics, Volume 91, Issue 4, Page 466-484, April 2023., 2023
Abstract Order and disorder govern protein functions, but there is a great diversity in disorder, from regions that are—and stay—fully disordered to conditional order. This diversity is still difficult to decipher even though it is encoded in the amino acid sequences.
Apolline Bruley, Tristan Bitard‐Feildel, Isabelle Callebaut, Elodie Duprat   +3 more
wiley   +1 more source

In vivo evaluation of alpha7 nicotinic acetylcholine receptor agonists [11C]A-582941 and [11C]A-844606 in mice and conscious monkeys. [PDF]

PLoS ONE, 2010
BackgroundThe alpha7 nicotinic acetylcholine receptors (nAChRs) play an important role in the pathophysiology of neuropsychiatric diseases such as schizophrenia and Alzheimer's disease.
Jun Toyohara, Kiichi Ishiwata, Muneyuki Sakata, Jin Wu, Shingo Nishiyama, Hideo Tsukada, Kenji Hashimoto   +6 more
doaj   +1 more source

Speculation on How RIC-3 and Other Chaperones Facilitate α7 Nicotinic Receptor Folding and Assembly

Molecules, 2022
The process of how multimeric transmembrane proteins fold and assemble in the endoplasmic reticulum is not well understood. The alpha7 nicotinic receptor (α7 nAChR) is a good model for multimeric protein assembly since it has at least two independent and
Ralph H. Loring
doaj   +1 more source

Dietary choline intake is necessary to prevent systems‐wide organ pathology and reduce Alzheimer's disease hallmarks

Aging Cell, Volume 22, Issue 2, February 2023., 2023
Dietary choline deficiency throughout adulthood induces motor impairments, weight gain, impaired glucose metabolism, cardiac and liver pathology, and exacerbates Alzheimer's Disease (AD) hallmarks. If generalized to humans, these findings may help mitigate the estimated increase in the prevalence of AD and illustrates the importance of adequate dietary
Nikhil Dave, Jessica M. Judd, Annika Decker, Wendy Winslow, Patrick Sarette, Oscar Villarreal Espinosa, Savannah Tallino, Samantha K. Bartholomew, Alina Bilal, Jessica Sandler, Ian McDonough, Joanna K. Winstone, Erik A. Blackwood, Christopher Glembotski, Timothy Karr, Ramon Velazquez   +15 more
wiley   +1 more source

Nicotinic receptor Alpha7 expression during tooth morphogenesis reveals functional pleiotropy. [PDF]

PLoS ONE, 2012
The expression of nicotinic acetylcholine receptor (nAChR) subtype, alpha7, was investigated in the developing teeth of mice that were modified through homologous recombination to express a bi-cistronic IRES-driven tau-enhanced green fluorescent protein (
Scott W Rogers, Lorise C Gahring
doaj   +1 more source

Physiologic Functions and Therapeutic Applications of α7 Nicotinic Acetylcholine Receptor in Brain Disorders

Pharmaceutics, 2022
Accumulating data suggest that α7 nicotinic acetylcholine receptors (α7nAChRs) are an important therapeutic target for the treatment of Alzheimer’s disease (AD) and schizophrenia.
Chien-Hsing Lee, Shih-Ya Hung
doaj   +1 more source

Heart development and regeneration—a multi‐organ effort

The FEBS Journal, Volume 290, Issue 4, Page 913-930, February 2023., 2023
Development and regeneration of the heart are processes controlled not only by intrinsic cardiac factors but also by molecular signals originating from other organs. While the former have been the focus of intense research, the importance of the latter has been recognized only more recently.
Alessandro Filosa, Suphansa Sawamiphak
wiley   +1 more source