Results 41 to 50 of about 2,375 (163)
Diabetic Medicine, Volume 39, Issue 6, June 2022., 2022 Abstract Aims Our aim was to synthesize current evidence on the association between parental smoking and incidence of type 1 diabetes and islet autoantibody positivity (IA) in the offspring by conducting a systematic review and meta‐analysis. Methods We searched Medline, Embase, and Cochrane Library until January 21, 2021, for human studies with ...
Jessica Edstorp +2 more
wiley +1 more source
Allenamides Playing Domino: A Redox‐Neutral Photocatalytic Synthesis of Functionalized 2‐Aminofurans
Advanced Synthesis &Catalysis, Volume 364, Issue 2, Page 362-371, January 18, 2022., 2022 Abstract A photoredox catalytic synthesis of functionalized 2‐aminofurans is proposed starting from α‐halo carbonyl substrates and N‐allenamides. The protocol proves to be efficient and sustainable thanks to: i) the use of visible light as green energy source, ii) the redox‐neutral nature of the transformation, allowing to avoid additives and strong ...
Arianna Quintavalla +6 more
wiley +1 more source
Alzheimer's disease drug development pipeline: 2022
Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 8, Issue 1, 2022., 2022 Abstract Introduction Alzheimer's disease (AD) represents a global health crisis. Treatments are needed to prevent, delay the onset, slow the progression, improve cognition, and reduce behavioral disturbances of AD. We review the current clinical trials and drugs in development for the treatment of AD.
Jeffrey Cummings +6 more
wiley +1 more source
Disease Markers, Volume 2022, Issue 1, 2022., 2022 Background. Exposure to nicotine has been observed associated with tumor progression, metastasis, and therapy resistance of many cancers. Hepatocellular carcinoma (HCC) is one major cancer related to the liver and the most difficult to treat malignancies worldwide.
Ching-Li Li +8 more
wiley +1 more source
Nicotinic Acetylcholine Receptors Assembled from the α7 and β3 Subunits [PDF]
Journal of Biological Chemistry, 1999 Intracellular recordings were performed in voltage-clamped Xenopus oocytes upon injection with a mixture of cDNAs encoding the beta3 and mutant alpha7 (L247Talpha7) neuronal nicotinic acetylcholine receptor (nAChR) subunits. The expressed receptors maintained sensitivity to methyllycaconitine and to alpha-bungarotoxin but exhibited a functional profile
PALMA, Eleonora +4 more
openaire +4 more sources
Stem Cell Research, 2018 CHRNA7, encoding the neuronal alpha7 nicotinic acetylcholine receptor (a7nAChR), is highly expressed in the brain, particularly in the hippocampus. It is situated in the 15q13.3 chromosome region, frequently associated with a Copy Number Variation (CNV),
Elisa Maria Turco +13 more
doaj +1 more source
Discovery of the Nicotinic Receptor Toxin Anabaseine in a Polystiliferan Nemertean
Toxins, 2023 Nemerteans (also called Nemertines) are a phylum of predominantly marine worms that use toxins to capture prey and to defend themselves against predators.
William R. Kem +3 more
doaj +1 more source
Alpha7 nicotinic acetylcholine receptor in macrophage apoptosis and efferocytosis
The FASEB Journal, 2012 The development of atherosclerotic lesions depends on an important inflammatory component mediated mostly by macrophages. Notably, apoptosis of macrophages within the lesion and efficient clearance of apoptotic cells are key factors in lesion progression.
Robert Lee, Guillermo Vazquez
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Stem Cell Research, 2019 The α7 nicotinic acetylcholine receptor has been extensively researched as a target for treatment of cognitive impairment in Alzheimer's disease and schizophrenia.
Hjalte M. Larsen +4 more
doaj +1 more source
Proteomic Analysis of an α7 Nicotinic Acetylcholine Receptor Interactome [PDF]
Journal of Proteome Research, 2009 The alpha7 nicotinic acetylcholine receptor (nAChR) is well established as the principal high-affinity alpha-bungarotoxin-binding protein in the mammalian brain. We isolated carbachol-sensitive alpha-bungarotoxin-binding complexes from total mouse brain tissue by affinity immobilization followed by selective elution, and these proteins were ...
Joao A, Paulo +2 more
openaire +2 more sources