Results 51 to 60 of about 2,375 (163)

Impaired Hippocampal Theta Oscillations in the Mice Null Alpha7 Nicotinic Acetylcholine Receptors [PDF]

CNS Neuroscience & Therapeutics, 2013
Nicotinic acetylcholine receptor (nAChR) a7 subunits are among the most ancient of vertebrate nAChR subunits and have the capacity to assemble as homomers. Naturally expressed a7-nAChRs in the central nervous system play a critical role in modulating the release of various neurotransmitters, neurite outgrowth, and even neuronal survival or death [1 ...
Yu, Jin, Quan-Xi, Su, Jian-Xin, Shen, Michael J, Marks, Jie, Wu   +4 more
openaire   +2 more sources

α7 Nicotinic acetylcholine receptor: a key receptor in the cholinergic anti-inflammatory pathway exerting an antidepressant effect

Journal of Neuroinflammation, 2023
Depression is a common mental illness, which is related to monoamine neurotransmitters and the dysfunction of the cholinergic, immune, glutamatergic, and neuroendocrine systems.
Huiyang Liu, Xiaomei Zhang, Peng Shi, Jiyuan Yuan, Qiang Jia, Chao Pi, Tao Chen, Linjin Xiong, Jinglin Chen, Jia Tang, Ruxu Yue, Zerong Liu, Hongping Shen, Ying Zuo, Yumeng Wei, Ling Zhao   +15 more
doaj   +1 more source

Neuroprotection of rat retinal ganglion cells mediated through alpha7 nicotinic acetylcholine receptors [PDF]

Neuroscience, 2013
Glutamate-induced excitotoxicity is thought to play an important role in several neurodegenerative diseases in the central nervous system (CNS). In this study, neuroprotection against glutamate-induced excitotoxicity was analyzed using acetylcholine (ACh), nicotine and the α7 specific nicotinic acetylcholine receptor (α7 nAChR) agonist, N-[(3R)-1 ...
K, Iwamoto, D, Mata, D M, Linn, C L, Linn   +3 more
openaire   +2 more sources

Modulation of alpha7 nicotinic acetylcholine receptor by cannabidiol

, 2022
Fil: Esandi, María del Carmen. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur.
Chrestia, Juan Facundo, Esandi, María del Carmen, Bouzat, Cecilia Beatriz   +2 more
openaire   +1 more source

Retinal ganglion cell neuroprotection induced by activation of alpha7 nicotinic acetylcholine receptors [PDF]

Neuropharmacology, 2015
The α7nAChR agonist, PNU-282987, has previously been shown to have a neuroprotective effect against loss of retinal ganglion cells (RGCs) in an in vivo glaucoma model when the agent was injected into the vitreous chamber of adult Long Evans rat eyes. Here, we characterized the neuroprotective effect of PNU-282987 at the nerve fiber and retinal ganglion
David Mata, David M. Linn, Cindy L. Linn
openaire   +2 more sources

Selective α7 nicotinic acetylcholine receptor agonists worsen disease in experimental colitis [PDF]

British Journal of Pharmacology, 2010
Background and purpose:  In various models vagus nerve activation has been shown to ameliorate intestinal inflammation, via nicotinic acetylcholine receptors (nAChRs) expressed on immune cells. As the α7 nAChR has been put forward to mediate this effect, we studied the effect of nicotine and two selective α7 nAChR agonists (AR‐R17779, (‐)‐spiro[1 ...
Snoek, Susanne A., Verstege, Marleen I., van der Zanden, Esmerij P., Deeks, Nigel, Bulmer, David C., Skynner, Michael, Lee, Kevin, te Velde, Anje A., Boeckxstaens, Guy E., de Jonge, Wouter J.   +9 more
openaire   +2 more sources

Characterization of a Bovine Serum Albumin‐Derived Pro‐Cognitive Peptide (bSAPP): An Orally Active Peptide Alleviates Cognitive Decline in HFD‐Fed Mice via CCK Signaling Through the Gut‐Brain Axis

The FASEB Journal, Volume 39, Issue 24, 31 December 2025.
The popularity of the Western diet has increased the prevalence of dementia in addition to aging. We found that the digest of bovine serum albumin and a peptide derived from the digest showed an oral pro‐cognitive effect in mice fed a high‐fat diet (HFD). We named the peptide bSAPP (EC50 = 0.01 mg/kg BW). The oral effect of bSAPP was modulated by CCK1R
Biyun Zhang, Mone Ando, Kohei Kawano, Yusaku Iwasaki, Kazuo Inoue, Kousaku Ohinata   +5 more
wiley   +1 more source

Genome‐wide pleiotropy analysis of longitudinal blood pressure and harmonized cognitive performance measures

Alzheimer's &Dementia, Volume 21, Issue 9, September 2025.
Abstract INTRODUCTION Identifying pleiotropy for blood pressure (BP) and cognitive performance measures may indicate mechanistic links between hypertension and Alzheimer's disease (AD). METHODS We performed a pleiotropy genome‐wide association study (GWAS) for paired measures of systolic, diastolic, pulse, and mean arterial pressure with memory ...
Moonil Kang, Ting Fang Alvin Ang, Sherral A. Devine, Richard Sherva, Shubhabrata Mukherjee, Emily H. Trittschuh, Phoebe Scollard, Michael Lee, Seo‐Eun Choi, Brandon Klinedinst, Connie Nakano, Logan C. Dumitrescu, Timothy J. Hohman, Michael L. Cuccaro, Andrew J. Saykin, Walter A. Kukull, David A. Bennett, Li‐San Wang, Richard P. Mayeux, Jonathan L. Haines, Margaret A. Pericak‐Vance, Gerard D. Schellenberg, Paul K. Crane, Rhoda Au, Kathryn L. Lunetta, Jesse Mez, Lindsay A. Farrer   +26 more
wiley   +1 more source

Alpha7 Nicotinic Acetylcholine Receptors Modulate Motivation to Self-Administer Nicotine: Implications for Smoking and Schizophrenia [PDF]

Neuropsychopharmacology, 2011
Individuals diagnosed with schizophrenia have an exceptionally high risk for tobacco dependence. Postmortem studies show that these individuals have significant reductions in α7 nicotinic acetylcholine receptors (nAChRs) in several brain areas. Decreased α7-mediated function might not only be linked to schizophrenia but also to increased tobacco ...
Brunzell, Darlene H, McIntosh, J Michael
openaire   +2 more sources

Matrix Metalloproteinase‐Responsive Controlled Release of Self‐Assembly Nanoparticles Accelerates Heart Valve Regeneration In Situ by Orchestrating Immunomodulation

Advanced Science, Volume 12, Issue 2, January 13, 2025.
After implantation of the immunoregulatory scaffold into the body, infiltrated immune cells produce MMP, enabling the degradation of MMP‐responsive hydrogels. Subsequently, galactose‐modified nanoparticles are exposed and phagocytosed by macrophages, triggering their transformation into an anti‐inflammatory phenotype.
Xing Chen, Yunlong Wu, Peng Song, Liandong Feng, Ying Zhou, Jiawei Shi, Nianguo Dong, Weihua Qiao   +7 more
wiley   +1 more source