Results 71 to 80 of about 909,137 (164)

The Putative Role of Human Peritoneal Adipocytes in the Fight against Bacteria: Synthesis of the Antimicrobial Active Peptide DEFA1-3 [PDF]

, 2010
Background: Spontaneous peritonitis is a rather rare event, even in peritoneal dialysis (PD). As defensins are natural antimicrobial peptides, we hypothesized that adipocytes as the major constituents of the omentum could play an important role in ...
Paslakis, Georgios, Schmid, Holger, Schloendorff, Detlef, Keuneke, Christian, Schroppel, Bernd, Groene, Hermann-Josef   +5 more
core   +1 more source

Plectasin, First Animal Toxin-Like Fungal Defensin Blocking Potassium Channels through Recognizing Channel Pore Region

Toxins, 2015
The potassium channels were recently found to be inhibited by animal toxin-like human β-defensin 2 (hBD2), the first defensin blocker of potassium channels. Whether there are other defensin blockers from different organisms remains an open question. Here,
Fang Xiang, Zili Xie, Jing Feng, Weishan Yang, Zhijian Cao, Wenxin Li, Zongyun Chen, Yingliang Wu   +7 more
doaj   +1 more source

Paneth cell alpha-defensin misfolding correlates with dysbiosis and ileitis in Crohn's disease model mice

, 2020
Crohn's disease (CD) is an intractable inflammatory bowel disease, and dysbiosis, disruption of the intestinal microbiota, is associated with CD pathophysiology.
Ohira, Shuya, Sugimoto, Rina, Shinozaki, Ryuga, Nakamura, Kiminori, Yoshii, Aki, Nakamura, Shunta, Yokoi, Yuki, Ayabe, Tokiyoshi, Shimizu, Yu, Kikuchi, Mani   +9 more
core   +1 more source

Human alpha defensin CNV haplotype diversity [PDF]

Humans have highly variable number of alpha defensin genes, with between 3-16 diploid copies. Alpha-defensin genes have important roles in human innate immunity and diseases.
Xu, Xiao
core  

Antimicrobial peptides and other potential biomarkers of critical illness in SARS‐CoV‐2 patients with acute kidney injury. AMPAKI‐CoV study

Physiological Reports
Antimicrobial peptides (AMPs) constitute a complex network of 10–100 amino acid sequence molecules widely distributed in nature. While over 300 AMPs have been described in mammals, cathelicidins and defensins remain the most extensively studied.
Lucas Ferreira Theotonio dos Santos, Hermes Vieira Barbeiro, Denise Frediani Barbeiro, Heraldo Possolo deSouza, Fabiano Pinheiro da Silva   +4 more
doaj   +1 more source

Interactions of mouse Paneth cell alpha-defensins and alpha-defensin precursors with membranes. Prosegment inhibition of peptide association with biomimetic membranes.

The Journal of biological chemistry, 2003
The bactericidal activity of mouse alpha-defensins (cryptdins) requires proteolytic activation of inactive precursors by matrix metalloproteinase-7 (matrilysin, EC, MMP-7(a)). To investigate mechanisms of cryptdin-4 (Crp4) peptide interactions with membrane bilayers and to determine whether MMP-7-mediated proteolysis activates the membrane disruptive ...
Donald P, Satchell, Tanya, Sheynis, Yoshinori, Shirafuji, Sofiya, Kolusheva, Andre J, Ouellette, Raz, Jelinek   +5 more
openaire   +2 more sources

Der Stellenwert von Alpha Defensin in der Diagnostik von periprothetischen Infektionen (PPI)

, 2021
Die Implantation von Kunstgelenken ist eine erfolgreiche und viel verwendete Operation, welche aufgrund der stetig älter werdenden Bevölkerung weiter zunimmt.
Kouba, Lukas
core   +1 more source

Distribution of human Β-defensin 2, TNF-alpha, IL-1 alpha, IL-6 and IL-8 in psoriatic skin

, 2011
Psoriasis is a chronic, inflammatory, proliferative condition of the skin, clinically characterized by red, scaly plaques. Psoriasis has a large and heterogenous genetic and immunologic background with the dysregulation of the host defense system.
Pilmane, Māra, Možeika, Elga, Ķīsis, Jānis   +2 more
core  

Alpha-defensin and the Synovasure lateral flow device for the diagnosis of prosthetic joint infection: a systematic review and meta-analysis [PDF]

, 2018
AimsThe aim of this review is to evaluate the available literature and to calculate a pooled diagnostic sensitivity and specificity for the different alpha-defensin test systems to diagnose peri-prosthetic infection.Materials and MethodsStudies using ...
B. A. Marson, Grindlay, D. J. C., D. J. C. Grindlay, B. E. Scammell, S. R. Deshmukh, Scammell, B. E., Marson, B. A., Deshmukh, S. R.   +7 more
core   +1 more source

α-Defensin Levels in Whole Saliva of Totally Edentulous Subjects

International Journal of Immunopathology and Pharmacology, 2008
Salivary levels of α-defensins 1–4 and histatins 1, 3 and 5 were determined in 11 totally edentulous patients, 11 younger healthy adults with normal gingival mucosa (Control group I) and 8 subjects, age-matched with edentulous patients, having a minimum of 25 teeth (Control group II).
FANALI C, INZITARI R, CABRAS, TIZIANA, PISANO E, CASTAGNOLA M, CELLETTI R, MANNI A, MESSANA, IRENE   +7 more
openaire   +4 more sources