Results 51 to 60 of about 909,137 (164)

In silico docking analysis of beta-defensin 20 against cation channel sperm-associated protein 1–4 to predict its role in the sperm maturation

Asian Journal of Andrology, 2023
Beta-defensin 20 (DEFB20) is widely expressed in the epididymis with gene features involved in epididymal sperm maturation. However, the action mechanism and function of DEFB20 in sperm maturation are still unclear.
Luluk Yunaini, Linda Erlina, Fadilah Fadilah, Dwi Ari Pujianto   +3 more
doaj   +1 more source

Determinants of Mouse Alpha‐Defensin Bactericidal Activity

The FASEB Journal, 2006
Mouse Paneth cell cryptdins are expressed as inactive propeptides and are activated upon proteolysis by MMP‐7. MMP‐7 cleavage sites Ser 43 ↓ Ile 44 , Ala 53 ↓ Leu 54 , and ...
Colby Sanford Weeks, Hiroki Tanabe, Steve P. Crampton, Melanie J. Cocco, Andre J. Ouellette   +4 more
openaire   +1 more source

Comparative Genomics and Evolution of the Alpha-Defensin Multigene Family in Primates [PDF]

Molecular Biology and Evolution, 2010
Defensin genes encode small cationic antimicrobial peptides that form an important part of the innate immune system. They are divided into three families, alpha (α), beta (β), and theta (), according to arrangement of the disulfide bonding pattern between cysteine residues.
Sabyasachi, Das, Nikolas, Nikolaidis, Hiroki, Goto, Chelsea, McCallister, Jianxu, Li, Masayuki, Hirano, Max D, Cooper   +6 more
openaire   +2 more sources

Insights into alpha-defensin modulation of non-enveloped viral infection [PDF]

, 2023
Thesis (Ph.D.)--University of Washington, 2023Alpha-defensins are small antimicrobial peptides that play a crucial role in innate immunity across various mammalian species.
Hu, Ciara Tipping
core  

Expression and clinical significance of defensin alpha 6 in colorectal cancer [PDF]

Korean Journal of Clinical Oncology, 2016
Purpose Defensin alpha 6 (DEFA6) is cationic short peptide with known functional activities in innate antimicrobial immunity. DEFA6 is also highly expressed in colorectal cancer tissue.
Saengjin Park, Taesung Ahn, Hyunyong Lee, Dong Jun Jeong, Hae Il Jeong, Myoung Won Son, Moon Soo Lee, Moo-Jun Baek   +7 more
doaj   +1 more source

Insight into the mechanisms of adenovirus capsid disassembly from studies of defensin neutralization.

PLoS Pathogens, 2010
Defensins are effectors of the innate immune response with potent antibacterial activity. Their role in antiviral immunity, particularly for non-enveloped viruses, is poorly understood.
Jason G Smith, Mariena Silvestry, Steffen Lindert, Wuyuan Lu, Glen R Nemerow, Phoebe L Stewart   +5 more
doaj   +1 more source

Alpha Defensins 1, 2, and 3 [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2007
Objectives— α-Defensins are natural antibiotics made by neutrophils that have been reported to modulate cholesterol metabolism and vascular function; however, their role in vivo remains largely unknown.
Abel, López-Bermejo, Berta, Chico-Julià, Antoni, Castro, Mònica, Recasens, Eduardo, Esteve, Josefina, Biarnés, Roser, Casamitjana, Wifredo, Ricart, José-Manuel, Fernández-Real   +8 more
openaire   +2 more sources

Vitamin D analogs differentially control antimicrobial peptide/"alarmin" expression in psoriasis [PDF]

, 2009
Antimicrobial peptides (AMPs) are strongly expressed in lesional skin in psoriasis and play an important role as proinflammatory "alarmins" in this chronic skin disease.
Koglin, Sarah, Ulrich Zügel, Thomas Ruzicka, Büchau Amanda, Dombrowski, Yvonne, Zügel, Ulrich, Steinmeyer, Andreas, Jürgen Schauber, Schauber, Jürgen, Büchau, Amanda, Sarah Koglin, Steinmeyer Andreas, Bradac, Eva, Mark Peric, Schauber Jürgen, Koglin Sarah, Amanda Büchau, Zügel Ulrich, Yvonne Dombrowski, Eva Bradac, Katrin Gross, Peric Mark, Gross, Katrin, Dombrowski Yvonne, Peric, Mark, Andreas Steinmeyer, Dombrowski, Yvonne; id_orcid, Bradac Eva, Groß Katrin, Ruzicka, Thomas, Ruzicka Thomas   +30 more
core   +2 more sources

Human α-defensins block papillomavirus infection [PDF]

Proceedings of the National Academy of Sciences, 2006
Sexually transmitted human papillomaviruses (HPVs) are the primary cause of cervical cancer. Recent advances in techniques for production of papillomaviral vectors [known as pseudoviruses (PsVs)] have made it possible to perform high-throughput screens for compounds that might block the initial stages of papillomavirus infection ...
Christopher B, Buck, Patricia M, Day, Cynthia D, Thompson, Jacek, Lubkowski, Wuyuan, Lu, Douglas R, Lowy, John T, Schiller   +6 more
openaire   +2 more sources

Data_Sheet_1_β-defensin-4 as an endogenous biomarker in cows with mastitis.docx

, 2023
IntroductionDefensins are peptides with antimicrobial and immunomodulatory effects. Their concentration could be altered during infections and thus provide information on the prognosis and course of the disease.
Anneke Fischer (14835181), Stephan Neumann (464917), Stephan Siegert (14835178)   +2 more
core   +1 more source