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An update on the use of alpha-defensin for the diagnosis of prosthetic joint infection: a narrative review [PDF]
The Egyptian Orthopaedic JournalBackground: The diagnosis of prosthetic joint infection (PJI) remains a clinical challenge. Recently, there has been growing interest in synovial fluid biomarkers, particularly alpha-defensin (AD), as tools to aid in PJI diagnosis.Methods: This narrative
Mohamed Askar +3 more
doaj +1 more source
Inhibition of pathologic retinal neovascularization by -defensins
Blood, 2005 Proliferative retinopathies, such as those complicating prematurity and diabetes, are major causes of blindness. A prominent feature of these retinopathies is excessive neovascularization, which is orchestrated by the hypoxia-induced vascular endothelial growth factor (VEGF) stimulating endothelial cells and the integrin-mediated adhesive interactions ...
Matina, Economopoulou +9 more
openaire +3 more sources
Inhibition of Pertussis Toxin by Human α-Defensins-1 and -5: Differential Mechanisms of Action
, 2023 Whooping cough is a severe childhood disease, caused by the bacterium Bordetella pertussis, which releases pertussis toxin (PT) as a major virulence factor.
Katharina Ernst +12 more
core +1 more source
Mechanism of Adenovirus Neutralization by Human α-Defensins [PDF]
Cell Host & Microbe, 2008 Defensins are naturally occurring antimicrobial peptides that disrupt bacterial membranes and prevent bacterial invasion of the host. Emerging studies indicate that certain defensins also block virus infection; however, the mechanism(s) involved are poorly understood.
Smith, Jason G., Nemerow, Glen R.
openaire +2 more sources
Bone & Joint ResearchAims: The diagnosis of periprosthetic joint infection (PJI) remains a challenge, as no single diagnostic test shows high diagnostic accuracy. Recently, the measurement of synovial biomarkers has shown promising results.
Martina Maritati +3 more
doaj +1 more source
, 2001 Copyright © 2001 by International Society for Peritoneal DialysisOBJECTIVE: To investigate the expression and regulation of defensins in the peritoneal cavity of peritoneal dialysis (PD) patients.
Atkins, G. +4 more
core +1 more source
Serum defensin levels in patients with systemic sclerosis
Advances in Rheumatology, 2020 Background Systemic sclerosis (SSc) is an autoimmune disease characterized by fibrosis of skin and lung as well as involvement of kidney, gastrointestinal system and heart. Aetiology and exact mechanism of disease is poorly understood.
Tugce Emiroglu Gedik +8 more
doaj +1 more source
Defensin alpha 6 (DEFA6) is a prognostic marker in colorectal cancer
Cancer Biomarkers, 2019 Defensin alpha 6 (DEFA6) is a member of the alpha defensin family of microbicidal and cytotoxic peptides that defend against bacteria and viruses. Here, we provide a novel function of DEFA6 in tumorigenesis of colorectal cancer (CRC) in vitro and in vivo.
Jeong, Dongjun +14 more
openaire +2 more sources
The Journal of biological chemistry, 2009 Paneth cells are a secretory epithelial lineage that release dense core granules rich in host defense peptides and proteins from the base of small intestinal crypts. Enteric alpha-defensins, termed cryptdins (Crps) in mice, are highly abundant in Paneth cell secretions and inherently resistant to proteolysis.
Jennifer R, Mastroianni +1 more
openaire +1 more source
Ibn Al-Haitham Journal for Pure and Applied SciencesNeutrophils in saliva cause tissue death in inflammatory disorders, including periodontal disease. Identifying biomarkers for neutrophil mediators is crucial for accurate diagnosis in periodontics research.
Fatima Sabah Jasim +1 more
doaj +1 more source