Diabetes and alpha lipoic acid [PDF]
Frontiers in Pharmacology, 2011 Diabetes mellitus is a multi-faceted metabolic disorder where there is increased oxidative stress that contributes to the pathogenesis of this debilitating disease.
Issy eLaher
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Alpha-Lipoic Acid Reduces NLRP3/ASC Expression and IL-1β Release in Kupffer Cells and Improves Insulin Signaling in FL83B Hepatocytes Exposed to a Conditioned Medium. [PDF]
Food Sci NutrAlpha‐lipoic acid (ALA) reduced NLRP3/ASC expression, attenuated upstream NF‐κB/ERK signaling, and decreased IL‐1β release while preserving mitochondrial membrane potential in murine Kupffer cells subjected to LPS priming and a second signal. Conditioned medium from ALA‐pretreated Kupffer cells (particularly 100 μM) enhanced glucose uptake and improved
Ko CY +6 more
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The Application of Lipoic Acid in Experimentally Induced Tympanosclerosis in Rats
Journal of Contemporary Medicine, 2020 Background/Aims:Tympanosclerosis is an abnormal tissue reaction resulting in sclerotic and hyalinization changes in the tympanic membrane and middle ear.
Fatih Turan +2 more
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Alpha-lipoic acid reduces body weight and regulates triglycerides in obese patients with diabetes mellitus [PDF]
Medicinski Glasnik, 2015 Aim To determine an influence of alpha-lipoic acid to reduction of body weight and regulation of total cholesterol concentration, triglycerides and glucose serum levels in obese patients with diabetes mellitus type 2.
Azra Okanović +3 more
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Alpha-Lipoic Acid and Diabetic Neuropathy [PDF]
The Review of Diabetic Studies, 2009 Diabetic neuropathy presents a major public health problem. It is defined by the symptoms and signs of peripheral nerve dysfunction in diabetic patients, in whom other causes of neuropathy have been excluded. Pathogenetic mechanisms that have been implicated in diabetic neuropathy are: a) increased flux through the polyol pathway, leading to ...
Natalia, Vallianou +2 more
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Effects of Silver Nanoparticles on the Ovarian Tissue of NMRI Rats Treated with Alpha Lipoic Acid: A Stereological Study [PDF]
مجله دانشگاه علوم پزشکی گرگان, 2023 Background and Objective: Silver nanoparticles are produced in large quantities in the industry and have estrogenic activities and toxic effects on different organs.
Seyed Mohammad Ali Shariatzadeh +2 more
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Flurbiprofen: Determination of safety profile, analgesic effect, and interaction with lipoic acid in murine [PDF]
Iraqi Journal of Veterinary Sciences, 2023 our study aimed study aimed to detect and investigate the safety profile of flurbiprofen and evaluate the analgesic effects of the tail immersion and writhing tests, as well as its interaction with lipoic acid as an analgesic for visceral pain in mice ...
Naktal M. Alberifki, Ahmed S. Naser
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Dietary Alpha-Lipoic Acid Alters Piglet Neurodevelopment [PDF]
Frontiers in Pediatrics, 2016 Alpha-lipoic acid (a-LA) is an antioxidant shown to ameliorate age-associated impairments of brain and cardiovascular function. Human milk is known to have high antioxidant capacity; however, the role of antioxidants in the developing brain is largely uncharacterized.
Austin T Mudd +7 more
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Dihydro-alpha-lipoic acid has more potent cytotoxicity than alpha-lipoic acid
In Vitro Cellular & Developmental Biology - Animal, 2009 Alpha-lipoic acid has been shown to possess cancer-cell-killing activity via activation of the apoptosis pathway. In this study, the cytotoxic activities of alpha-lipoic and dihydro-alpha-lipoic acid were compared in HL-60 cells. The cell-killing activity of dihydro-alpha-lipoic acid was higher than that of alpha-lipoic acid.
Masao, Yamasaki +9 more
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Efficacy of the R(+)-enantiomer of alpha-lipoic acid in clinical practice
Mìžnarodnij Endokrinologìčnij Žurnal, 2021 The article presents current data from the scientific medical literature on the effective use of the R(+)-enantiomer of α-lipoic acid in various pathological conditions.
N.О. Kravchun, I.P. Dunaieva
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