Experimental Study of the Possible Protective Effect of Alpha-Lipoic Acid on Paracetamol induced Oxidative Stress and Hepatic Toxicity in albino rats [PDF]
Ain Shams Journal of Forensic Medicine and Clinical Toxicology, 2021 Background: Paracetamol, is the most widely used over-the-counter analgesic and antipyretic medication in the world, which has minimal adverse effects at therapeutic dosages. But in high doses causes hepatic damage and oxidative stress.
Maha Hilal +4 more
doaj +1 more source
Alpha-Lipoic Acid for the Prevention of Diabetic Macular Edema [PDF]
, 2011 Introduction: To evaluate the effect of alpha-lipoic acid (ALA) on the occurrence of diabetic macular edema. Methods: Randomized, double-blind, placebo-controlled, multicenter, multinational study. Patients were randomized to the treatment group with 600
Haritoglou, Christos +10 more
core +1 more source
Activity of serum paraoxonase 1, lipid profile and atherogenic indexes in diabetic induced rats treated with alpha lipoic acid [PDF]
Journal of Nephropathology, 2018 Background: Paraoxonase 1 (PON1) is an enzyme attached to high density lipoprotein (HDL-C) which has antioxidant and anti-atherogenic activities. Objectives: In this study, we investigated the effects of alpha lipoic acid on PON1 activity, lipid profile ...
Parisa Jamor +3 more
doaj +1 more source
Estimation of pharmacokinetic parameters of alpha-lipoic acid in the chicks model
Baghdad Journal of Biochemistry and Applied Biological Sciences, 2022 Background and objective: Alpha-lipoic acid is a drug used to treat diabetic neuropathy, and it has other uses as a dietary supplement. The target of the study was to investigate the concentration of therapeutic doses of Alpha-lipoic acid in the blood ...
Marwa R. Abdulghani, Ahmed S. Naser
doaj +1 more source
Apicoplast lipoic acid protein ligase B is not essential for Plasmodium falciparum [PDF]
, 2007 Lipoic acid (LA) is an essential cofactor of α-keto acid dehydrogenase complexes (KADHs) and the glycine cleavage system. In Plasmodium, LA is attached to the KADHs by organelle-specific lipoylation pathways.
Ryan Bissett +45 more
core +1 more source
Качественная клиническая практика, 2021 Rational pharmacotherapy in the Program of Preferential Medicinal Providing can be implemented subject to high-quality information support from healthcare professionals.
E. V. Eliseeva +4 more
doaj +1 more source
Role of Alpha Lipoic Acid on Cyclophosphamide Induced Cardiotoxicity in Adult Male Albino Rat: Histological Study [PDF]
The Egyptian Journal of Histology, 2019 Background: Cyclophosphamide is a chemotherapeutic agent used for treatment of leukemia, lymphoma and myeloma. Several studies reported wide range of cyclophosphamide induced cardiotoxicity in cancerous patients.
manar bashandy, omyma zedan
doaj +1 more source
Knockout studies reveal an important role of plasmodium lipoic acid protein ligase a1 for asexual blood stage parasite survival [PDF]
, 2009 Lipoic acid (LA) is a dithiol-containing cofactor that is essential for the function of a-keto acid dehydrogenase complexes. LA acts as a reversible acyl group acceptor and 'swinging arm' during acyl-coenzyme A formation.
Sylke Müller +9 more
core +2 more sources
Alpha-Lipoic Acid Is an Effective Nutritive Antioxidant for Healthy Adult Dogs
Animals, 2021 This study was designed to determine the effect of alpha-lipoic acid on the glutathione status in healthy adult dogs. Following a 15 month baseline period during which dogs were fed a food containing no alpha-lipoic acid, dogs were randomly allocated ...
Reshma M. Anthony +4 more
doaj +1 more source
Alpha-lipoic acid – a health-promoting compound [PDF]
, 2021 Nutrition is one of the most important factors influencing health status and physical performance. Alpha-lipoic acid is a potent antioxidant. It regulates mitochondrial metabolism and protects cells against oxidative stress.
Mirowski, Adam
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