Results 51 to 60 of about 3,275,969 (247)
Clinical Approaches to the Treatment of Diabetic Neuropathy
Mìžnarodnij Endokrinologìčnij Žurnal, 2014 The article is devoted to the treatment of diabetic neuropathy. The described scheme of application of preparations of alpha-lipoic (thioctic) acid. Recently in Europe and the United States conducted a series of clinical studies that have shown that the ...
A.V. Kaminsky
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Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2020 Diabetic neuropathy (DN) is the most common chronic complication of diabetes mellitus. Hyperglycemia-induced oxidative stress induces programmed cell death of nerves, which contributes to the pathology of Diabetic neuropathy. Many clinical trials depend
Rusul AbdulKareem Hadi +2 more
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Chemical Bond‐Orchestrated Energy Depletion to Augment Lung Cancer Chemo‐Immunotherapy
Advanced Science, EarlyView.This study grafted dichloroacetic acid (DCA) into perylenediimide (PDI) skeleton via ionic or covalent bond to create novel metabolic agent PDIC‐AC and PDIC‐NAC, explicitly elaborated the underlying energy metabolism and therapeutic mechanism, and developed a promising strategy for energy metabolism‐targeting chemo‐immunotherapy by chemical bond ...
Xuejie Zhao +5 more
wiley +1 more source
Anticholesterol Activity of α-Lipoic Acid [PDF]
Nature, 1958 SINCE α-lipoic acid is known to affect lipid metabolism, we have investigated the effect of this acid on the lipid content of plasma, liver and aorta from rabbits which had been fed on a diet containing an excess of cholesterol1. Rabbits weighing 2.5–3 kgm. were divided into four groups, each containing five animals.
L, ANGELUCCI, E, MASCITELLI-CORIANDOLI
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Advanced Science, EarlyView.A bioactive adhesive hydrogel capable of long‐term uterine retention (>14 days) and local microenvironment modulation is developed by straightforward integration of α‐lipoic acid, L‐arginine, tannic acid, and Lactobacillus johnsonii, which can markedly enhance endometrial repair and restore fertility in a rat model of endometrial injury.
Lifa Chen +9 more
wiley +1 more source
Efficacy of the R(+)-enantiomer of alpha-lipoic acid in clinical practice
Mìžnarodnij Endokrinologìčnij Žurnal, 2021 The article presents current data from the scientific medical literature on the effective use of the R(+)-enantiomer of α-lipoic acid in various pathological conditions.
N.О. Kravchun, I.P. Dunaieva
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α-Lipoic Acid and Cardiovascular Disease [PDF]
The Journal of Nutrition, 2003 Alpha-lipoic acid (ALA) has been identified as a powerful antioxidant found naturally in our diets, but appears to have increased functional capacity when given as a supplement in the form of a natural or synthetic isolate. ALA and its active reduced counterpart, dihydrolipoic acid (DHLA), have been shown to combat oxidative stress by quenching a ...
Stephanie D, Wollin, Peter J H, Jones
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The effects of lipoic acid on rat submandibular salivary gland in valproic acid induced oxidative stress [PDF]
576-583Valproic acid (VA), an anticonvulsant drug, has been associated with various toxic effects, primarily through the induction of oxidative stress.
Veli Ustundag, Unsal +12 more
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Advanced Science, EarlyView.The DLST K409 succinylation mediated by CPT1A promotes OXPHOS and redox homeostasis through regulating enzyme activity, thereby promoting the malignant progression of LUAD. Notably, the succinylation of DLST can enhance the cuproptosis resistance by inhibiting its lipoylation.
Xuanxuan Li +9 more
wiley +1 more source
A Case of Multiple Mitochondrial Dysfunctions Syndrome 1 and Review of the Literature
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT Multiple mitochondrial dysfunctions syndrome 1 (MMDS1, MIM #605711) due to NFU1 gene defects is an ultra‐rare autosomal recessive inborn error of metabolism associated with reduced function of NFU1 iron–sulfur cluster (ISC) scaffold protein.
Charles R. DiFalco +6 more
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