Results 61 to 70 of about 3,499,347 (226)
Clinical Approaches to the Treatment of Diabetic Neuropathy
Mìžnarodnij Endokrinologìčnij Žurnal, 2014 The article is devoted to the treatment of diabetic neuropathy. The described scheme of application of preparations of alpha-lipoic (thioctic) acid. Recently in Europe and the United States conducted a series of clinical studies that have shown that the ...
A.V. Kaminsky
doaj +1 more source
Journal of Diabetes Research, 2015 After evaluating the prevalence of early endothelial dysfunction, as measured by means of reactive hyperemia in adolescents with type 1 diabetes, we started a 6-month, double-blind, randomized trial to test the efficacy of an antioxidant diet (± alpha ...
Andrea Scaramuzza +8 more
doaj +1 more source
Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2020 Diabetic neuropathy (DN) is the most common chronic complication of diabetes mellitus. Hyperglycemia-induced oxidative stress induces programmed cell death of nerves, which contributes to the pathology of Diabetic neuropathy. Many clinical trials depend
Rusul AbdulKareem Hadi +2 more
doaj +1 more source
Anticholesterol Activity of α-Lipoic Acid [PDF]
Nature, 1958 SINCE α-lipoic acid is known to affect lipid metabolism, we have investigated the effect of this acid on the lipid content of plasma, liver and aorta from rabbits which had been fed on a diet containing an excess of cholesterol1. Rabbits weighing 2.5–3 kgm. were divided into four groups, each containing five animals.
L, ANGELUCCI, E, MASCITELLI-CORIANDOLI
openaire +2 more sources
, 2011 Courtney E McIlduff, Seward B RutkoveDepartment of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USABackground: The most common of the neuropathies associated with diabetes mellitus, diabetic sensorimotor polyneuropathy (DSPN) is a ...
Seward Rutkove +3 more
core +1 more source
Alpha lipoic acid for dementia
, 2004 BACKGROUND: Oxidative processes have been implicated in the pathogenesis of neurodegenerative dementias including Alzheimer's disease. Protecting the central nervous system against these damaging mechanisms may be a useful therapeutic approach.
Tabet, N, Sauer, J, Howard, R
core +3 more sources
α-Lipoic Acid and Cardiovascular Disease [PDF]
The Journal of Nutrition, 2003 Alpha-lipoic acid (ALA) has been identified as a powerful antioxidant found naturally in our diets, but appears to have increased functional capacity when given as a supplement in the form of a natural or synthetic isolate. ALA and its active reduced counterpart, dihydrolipoic acid (DHLA), have been shown to combat oxidative stress by quenching a ...
Stephanie D, Wollin, Peter J H, Jones
openaire +2 more sources
Translational development of crisugabalin for neuropathic pain
British Journal of Clinical Pharmacology, EarlyView.Abstract Crisugabalin (HSK16149) is a next‐generation α2δ ligand developed to preserve the mechanistic rationale of gabapentinoids while refining target engagement and exposure‐related tolerability constraints. We performed a translational review of molecular/structural studies, in vivo pharmacology and behavioural safety assessments, phase I clinical ...
Rafael Batista João +5 more
wiley +1 more source
Efficacy of the R(+)-enantiomer of alpha-lipoic acid in clinical practice
Mìžnarodnij Endokrinologìčnij Žurnal, 2021 The article presents current data from the scientific medical literature on the effective use of the R(+)-enantiomer of α-lipoic acid in various pathological conditions.
N.О. Kravchun, I.P. Dunaieva
doaj +1 more source
Tackling cancer stemness with nanotechnology in the era of precision medicine
BMEMat, EarlyView.Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo +9 more
wiley +1 more source