Results 31 to 40 of about 10,851 (203)

74 Alpha Lipoic Acid Responsive Hypergeusia [PDF]

CNS Spectrums, 2019
AbstractIntroductionImprovement in hypergeusia in response to alpha lipoic acid treatment has not heretofore been described. Such a case is presented.MethodsCase Study: A 64 year old right handed nasute female noted the sudden onset of salty hypergeusia, about 200% saltier than foods should be.
Sarah E. Cormie, Alan R. Hirsch
openaire   +1 more source

Asymmetric Cu─N─Ru Bridgedsite Nanozyme‐Loaded Injectable Thermogel Boosts Cuproptosis‐Like Death for Multidrug‐Resistant Urinary Tract Infections

Advanced Science, EarlyView.
To address multidrug‐resistant urinary tract infections (MDR‐UTIs), we developed Cu‐ZIF8‐Ru nanozyme featuring an asymmetric Cu─N─Ru catalytic site. This unique structure enhances multienzyme‐mimetic activity, eradicating resistant bacteria by inducing a cuproptosis‐like death pathway through intracellular Cu2+ accumulation and energy depletion.
Guanlin Li, Shike Zhang, Jinggong Liu, Xin Wang, Heng Wang, Hongcan Yang, Yuhao Zhou, Wen Liu, Hongxing Liu, Wenqi Wu   +9 more
wiley   +1 more source

Metarhizium anisopliaeMitigates the Phytotoxicity of Lead and Nanoplastics on Rice by Modifying Physiological, Transcriptomic, Metabolomic Activities, and Soil Microbiome

Advanced Science, EarlyView.
Metarhizium anisopliae alleviates the phytotoxic effects of polyethylene nanoplastics (NP) and lead (Pb) in rice by decreasing Pb uptake, restoring antioxidant and hormonal equilibrium, and promoting growth. Additionally, the fungus modifies the rhizosphere microbiota, enhancing both contaminant tolerance and plant growth, thereby effectively ...
Jing Peng, Qi Yan, Muhammad Umair Hassan, Muhammad Imran, Fasih Ullah Haider, Jianfeng Liang, Xingmin Wang, Shaukat Ali   +7 more
wiley   +1 more source

The Effect of Alpha-Lipoic Acid against Methotrexate on Testicular Damage in Rats

Journal of Contemporary Medicine, 2023
Aim: The toxic effects of methotrexate, a chemotherapeutic, on the testicles is an important side effect. Methotrexate impairs spermatogenesis and fertility and causes oligospermia. In this study, we aimed to minimize the testicular toxicity, those being
Ahmetcan Varel, Meltem Özgöçmen, Hamit Hakan Armağan, İbrahim Aydın Candan, Dilek Bayram, İlkay Armağan   +5 more
doaj   +1 more source

Alpha-lipoic acid for diabetic peripheral neuropathy. [PDF]

Cochrane Database Syst Rev, 2018
Diabetic peripheral neuropathy (DPN) is a frequent complication in people living with type 1 or type 2 diabetes. There is currently no effective treatment for DPN. Although alpha-lipoic acid (ALA, also known as thioctic acid) is widely used, there is no consensus about its benefits and harms.To assess the effects of alpha-lipoic acid as a disease ...
Baicus C, Purcarea A, von Elm E, Delcea C, Furtunescu FL.   +4 more
europepmc   +4 more sources

Combining Electrochemical Reduction with Biosynthesis for Directed Conversion of CO2 into a Library of C3 Chemicals

Advanced Science, EarlyView.
In the H‐type electrolytic cell, carbon dioxide is reduced to acetic acid via electro‐microbial catalysis. The simply processed acetic acid is further converted through biological fermentation into high‐value‐added products, including acrylic acid, L‐lactic acid, and β‐alanine.
Kaixing Xiao, Shanquan Liang, Xujun Zhao, Zhiyao Peng, Ruoshi Luo, Jikai Zong, Ling Zhou, Yude Su, Dan Wang   +8 more
wiley   +1 more source

Protective effect and mechanism of alpha-lipoic acid on lead-induced Sertoli cell damage in rooster testes

Asian Pacific Journal of Reproduction
Objective: To investigate the protective effect of alpha-lipoic acid on lead-induced Sertoli cell injury and its potential molecular mechanisms using primary Sertoli cells from rooster testes. Methods: Primary Sertoli cells from 6-week-old rooster testes
Junrong Li, Shanli Zhu, Nanwei Ye, Fangxiong Shi   +3 more
doaj   +1 more source

Metal‐Supramolecular Drug Delivery System Empowered Meningeal Lymphatic Vessels‐Bridged Intracranial‐Peripheral Dual Immune Modulation for Reversing Glioblastoma Immune Suppression

Advanced Science, EarlyView.
A novel metal‐supramolecular nanoplatform (FLM@VC) enables efficient brain delivery via meningeal lymphatic vessels (MLVs), bypassing the blood‐brain barrier (BBB) through subcutaneous administration. It reprograms tumor‐associated macrophages (TAMs) and remodels the MLVs to promote DC trafficking and CD8+ T cell activation.
Chenxi Zhang, Zhongsheng Xu, Xiaowen Xu, Zening Zhang, Ranran Luo, Pengchen Ren, Yingying Luo, Qiuchi Wu, Xinyu Liu, Guodong Liu, Xiaojing He, Yun Liu   +11 more
wiley   +1 more source

Alpha-lipoic acid drugs in the treatment of diabetic neuropathy

Медицинский совет, 2014
Diabetic neuropathy is the most common complication of diabetes mellitus. Among the large number of drugs used as symptomatic therapy to reduce its manifestations, alpha-lipoic acid medications are specific for providing pathogenic effect on many ...
L. Y. Morgunov
doaj   +1 more source

Advances and Challenges in Micro/Nanocarrier‐Based Dermal Drug Delivery Systems for Acne Treatment

Advanced NanoBiomed Research, EarlyView.
Topical acne treatment faces challenges from skin barriers and complex causes. Micro/nanocarriers improve drug delivery by enhancing bioavailability, targeting, and duration. Combining carriers creates synergistic effects for systematic intervention.
Jintao Yang, Jie Chen, Yunmiao Ma, Qingwei Zhou, Yu Kong, Yingxiang Chen, Junjie Chi, Haihua Hu   +7 more
wiley   +1 more source