Results 81 to 90 of about 10,851 (203)

NADH‐Reductive Stress Induced by Dihydrolipoamide Dehydrogenase Activation Contributes to Cuproptosis

Advanced Science, Volume 13, Issue 9, 13 February 2026.
This study demonstrates a cuproptosis mechanism involving nicotinamide adenine dinucleotide (NADH)‐reductive stress in neural cells. Copper activates dihydrolipoamide dehydrogenase under mitochondrial pH, accumulating NADH. Copper also induces mitochondrial permeability transition pore opening, facilitating NADH translocation to the cytosol and ...
Si‐Yi Zhang, Xing‐Hua Ren, Cheng‐Hong Zhang, Zhan‐You Wang   +3 more
wiley   +1 more source

Neuroprotective effects of α-lipoic acid on the development of oxidative stress and astrogliosis in the brain of STZ-diabetic rats

Regulatory Mechanisms in Biosystems, 2014
The aim of this study was to examine whether the antioxidant alpha-lipoic acid protects neurons from diabetic-reperfusion injury. The streptozotocin (STZ) rat model was used to study the glial reactivity and prevention of gliosis by alpha-lipoic acid ...
S. Kyrychenko, I. Prishchepa, V. Lagoda, M. Velika, V. Nedzvetsky   +4 more
doaj   +1 more source

Bridging Scales in Flexible Perovskite Solar Cells: Mechanisms, Interfaces, and Applications

Advanced Science, Volume 13, Issue 12, 27 February 2026.
This perspective focuses on the advancement of flexible perovskite solar cells (f‐PSCs) from the energetic point of view, and summarizes the mechanisms, material characteristics, device performance, and failure mechanisms across the microscopic, mesoscopic, and macroscopic scales through mechanical energy dissipation theory.
Yan Wang, Zexin Yu, Chunlei Zhang, Ning Wang, Francesco Vanin, Bo Li, Nan Li, Meng Liao, Zonglong Zhu   +8 more
wiley   +1 more source

Efficacy of Using Alpha-Lipoic Acid in Diabetic Neuropathy

Mìžnarodnij Endokrinologìčnij Žurnal, 2015
The article presents a review of literature and research demonstrating the effectiveness of using alpha-lipoic acid in diabetic neuropathy.
V.I. Pankiv
doaj   +1 more source

New Insights on Heat Shock Proteins as Regulators of Reactive Oxygen Species Across Various Stressors in Diseases

Cell Biochemistry and Function, Volume 44, Issue 2, February 2026.
ABSTRACT Living beings are persistently challenged by stress. Stress can be induced by internal stressors and external stressors. External stressors, including radiation, heat, heavy metals, nutritional imbalances, infections, and psychological stress, can induce protein denaturation, leading to misfolded or aggregated proteins.
Paka Sravan Kumar, Triveni Kodi, Adarsh Gopinathan, Bharath Harohalli Byregowda, Krishnadas Nandakumar, Anoop Kishore   +5 more
wiley   +1 more source

Clinical Presentation and Treatment of Hyperemesis Gravidarum in a Lady Carrying Twins in the First Trimester: A Case Reports

Clinical Case Reports, Volume 14, Issue 2, February 2026.
ABSTRACT We report a 12‐week‐old pauci‐geste carrying twins who experienced potentially fatal hyperemesis gravidarum. Clinical and paraclinical investigations revealed severe hypovolemic shock/dehydration, ionic disruption, undernutrition, and acute renal failure (GFR: 36.8 mL/min/1.73 m2 according to modified MDRD). The patient spent almost 3 weeks in
Kesheni Banyanga David, Carmel Mbalo Walemba, Vanessa Ndamuso Nshombo, Marc Burume, Bushambale Rudeha Agath, Laurent Kasongo, Germain Mugisho Matabaro, Gaston Masimango, Trésor Okamba Alangi, Philémon Matabishi, Patient Wimba Mijiriro   +10 more
wiley   +1 more source

Effect of alpha Lipoic Acid on Some Reproductive Hormones in Adult Male Wister Rats Exposed to Hydrogen Peroxide

Kufa Journal for Veterinary Medical Sciences, 2019
The present study was aimed to investigate the role of alpha lipoic acid (ALA) on reproductive hormonal profile in adult male Wister rats treated with hydrogen Peroxide.
Mohammed Salih Alwan, Baraa Najim Al-Okialy   +1 more
doaj   +1 more source

Alpha-Lipoic Acid

Nguyen H, Pellegrini MV, Gupta V.
europepmc   +2 more sources

BACH2 alleviates immune checkpoint inhibitors‐induced cardiac pyroptosis via transcriptionally promoting GRSF1

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
Immune checkpoint inhibitors cause elevated cardiac injuries in humans and mice. ICIs cause myocyte pyroptosis and cardiotoxicity, not via the adaptive immune system BACH2 ameliorates ICIs‐induced pyroptosis through transcriptionally promoting GRSF1. Lipoic acid, as a transcriptional inducer of BACH2, suppresses ICIs‐induced cardiotoxicity.
Mengying Cao, Zilong Liu, Di Zhao, Hongyuan Zhang, Xinjie He, Wenhao Wang, Xiaolin Wang, Cheng Yang, Pan Gao, Yunzeng Zou   +9 more
wiley   +1 more source

Protective role of feed additives against gossypol-induced immunosuppression and oxidative damage in quails

Discover Animals
This study investigated the protective effects of four feed additives-turmeric (Curcuma longa), probiotic, multi-enzyme, and alpha-lipoic acid-against gossypol-induced immunosuppression and oxidative damage in quails.
Bagher Heydari-Sadegh, Kamal Shojaeian, Farzad Bagherzadeh-Kasmani, Mahmoud Ghazaghi, Aida Davari   +4 more
doaj   +1 more source