Results 101 to 110 of about 3,499,347 (226)

Consensus Guidelines for Diagnosis and Management of Pyruvate Dehydrogenase Complex Deficiency

Journal of Inherited Metabolic Disease, Volume 49, Issue 6, November 2026.
ABSTRACT Primary pyruvate dehydrogenase complex deficiency (PDCD) comprises a group of monogenic disorders caused by pathogenic variants in genes encoding subunits of, or regulatory components affecting, the pyruvate dehydrogenase complex. The clinical phenotype spans a broad continuum, ranging from early onset congenital lactic acidosis to infantile ...
Nandaki Keshavan, Julia Neugebauer, Marcello Bellusci, Enrico Bertini, Garry Brown, Niklas Darin, Suzanne DeBrosse, Lucy Drexler, Stefan Drexler, Gregory M. Enns, Rebecca D. Ganetzky, Kelly Gilbert, Austin Larson, Rebecca Legi, April N. Lehman, Camile Newby, Manuel Schiff, Rachel Skeath, Peter W. Stacpoole, Sarah Thompson, Emma Watt, Saskia B. Wortmann, Jirair K. Bedoyan, Shamima Rahman   +23 more
wiley   +1 more source

Histological Study on The Effect of Tamoxifen on The Retina of Adult Male Albino Rats and The Potential Ameliorative Effect of Alpha Lipoic Acid [PDF]

Ain Shams Medical Journal
Background: Tamoxifen is used in cases of gynecomastia, benign prostatic hyperplasia and breast cancer. Alpha-lipoic acid (ALA) is a natural antioxidant found in human diet.
Nehal El-Helbawy
doaj   +1 more source

Chelation‐Assisted Metal‐Catalyzed Ligation and Cleavage Reactions for Chemical Biology

European Journal of Organic Chemistry, Volume 29, Issue 39, 22 October 2026.
Chelation‐assisted transition metal catalysis has emerged as a promising complement to bioorthogonal click chemistry for studying biological processes. By pre‐organizing catalytic metal centers, designed coordinating substrates enhance reactivity and biocompatibility, enabling site‐selective ligation and decaging reactions in complex biological media ...
Emilie Plantiveau, Maxime Riberaud, Frédéric Taran, Antoine Sallustrau   +3 more
wiley   +1 more source

Hypotensive effect of alpha-lipoic acid after a single administration in rats [PDF]

, 2016
Objective: The effect of alpha-lipoic acid on blood pressure was investigated many times in chronic studies, but there are no studies on the effect of this compound after a single administration.
Razny, Katarzyna, Bilska-Wilkosz, Anna, Filipek, Barbara, Sapa, Jacek, Włodek, Lidia B., Kotańska, Magdalena, Iciek, Małgorzata   +6 more
core   +1 more source

Effect of the Administration of Alpha-Lipoic Acid on Contrast Sensitivity in Patients with Type 1 and Type 2 Diabetes

Mediators of Inflammation, 2014
The aim of this study was to estimate the effects of oral supplementation of alpha-lipoic acid (ALA) on contrast sensitivity (CS) in patients with type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM).
Anna Gębka, Ewelina Serkies-Minuth, Dorota Raczyńska   +2 more
doaj   +1 more source

Transformative Masked Ortho‐Quinone Chemistry: From Direct Guaiacol Activation to Lignin‐Based Adhesives

Angewandte Chemie International Edition, Volume 65, Issue 43, 19 October 2026.
Renewable guaiacols are rapidly oxidized by phenyliodine(III)diacetate to masked ortho‐quinones, giving a new class of monomers that undergo selective Michael‐type polyaddition with multithiols to from thiol‐guaiacol connectivity‐bearing polymers. The activation applies to discrete monomers and directly to lignin, enabling two‐component adhesives that ...
Dominik P. Hoch, Keven Walter, Oliver Sipura, Jana Falkenhagen, Xinyang Peng, Leon Gerndt, Hamy Nguyen, Hans G. Börner   +7 more
wiley   +1 more source

Targeting Oxidative and Immune Dysregulation in Wound Healing via Gold Nanoparticle Conjugate Chitosan

The FASEB Journal, Volume 40, Issue 19, 15 October 2026.
This gold nanoparticle–chitosan (AuNP@chitosan) composite promotes burn wound healing by simultaneously regulating endothelial and immune responses. In vitro, the composite protects TNF‐α‐injured HUVECs by reducing ROS, restoring thrombomodulin, and upregulating hypoxia‐adaptive markers.
Sheng‐Der Hsu, Shu‐Jen Chang, Cheng‐An Lin, Gang‐Yi Fan, Hsin‐Da Tsai, Amber Lin, Juin‐Hong Cherng   +6 more
wiley   +1 more source

Effects of Alpha-Lipoic Acids on Sperm Membrane Integrity during Liquid Storage of Boar Semen

Scientific Papers Animal Science and Biotechnologies, 2023
Preliminary studies have shown that sperm membrane from swine shows high sensitivity to cryopreservation process, causing a dramatic reduction in sperm quality.
Laura Parlapan Pîndaru, Ioan Ștefan Groza   +1 more
doaj  

The impact of alpha-lipoic acid on amikacin-induced nephrotoxicity

Renal Failure, 2014
Amikacin (AK) is an antibacterial drug, but it has remarkable nephrotoxic and ototoxic side effects due to increase in reactive oxygen radicals. This study was established to determine the possible protective effects of alpha-lipoic acid (ALA), a powerful antioxidant, on AK-induced nephrotoxicity.
AŞCI, Halil, İLHAN, İlter, CANKARA, Fatma Nihan, YEŞİLOT, Sukriye, BAYRAM, Dilek, SAYGIN, Mustafa, CANDAN, Ibrahim Aydin   +6 more
openaire   +5 more sources

Antimicrobial Effect of Alpha Lipoic Acid Against Oral Microorganisms. [PDF]

, 2020
Aim: This study was aimed to assess the antibacterial effect of alpha lipoic acids against various oral microorganisms. Background: Oral microorganisms are responsible for oral related diseases.Oral microorganisms implicated in the etiology of dental ...
S , SHEBI, D, EZHILARASAN
core