Results 111 to 120 of about 27,826 (225)

Elevated serum HER‐2 predicts poor prognosis in breast cancer and is correlated to ADAM10 expression

Cancer Medicine, 2019
Human epidermal growth factor receptor‐2 (HER‐2) overexpression in breast tumor tissues is associated with a poor prognosis but may benefit from treatment with trastuzumab.
Hui Zheng, Ailing Zhong, Suhong Xie, Yanchun Wang, Jiajun Sun, Jie Zhang, Ying Tong, Miaomiao Chen, Guihong Zhang, Qian Ma, Jinyan Kai, Lin Guo, Renquan Lu   +12 more
doaj   +1 more source

Neuroprotective role of epigallocatechin-3-gallate, albeginin and melanoxetin in alzheimer's disease

Phytomedicine Plus
Background: Alzheimer's disease (AD) is a heterogeneous and progressive neurodegenerative disorder characterized by cognitive impairment and behavioral disturbances.
Arif Malik, Mehreen Hassan, Sulayman Waquar, Muhammad Wasim, Anam Naz, Faryal M. Awan, Muhammad T. Khan, Ali I. Khawaja, Sumera Zaib, Jamshed Iqbal, Ayesha Zahid, Marvi Marvi, Javeid Iqbal, Heng Wang, Dong-Qing Wei   +14 more
doaj   +1 more source

The potential role of dietary polyphenols in Parkinson’s disease [PDF]

, 2011
Cumulative evidence now suggests that the abnormal aggregation of the neuronal protein alpha-synuclein is critically involved in the pathogenesis of synucleinopathies, of which Parkinson’s disease (PD) is the most prevalent. Development of neuropathology
Caruana, Mario, Vassallo, Neville
core  

Alpha-lipoic acid alleviates cognitive deficits in transgenic APP23/PS45 mice through a mitophagy-mediated increase in ADAM10 α-secretase cleavage of APP

Alzheimer’s Research & Therapy
Background Alpha-lipoic acid (ALA) has a neuroprotective effect on neurodegenerative diseases. In the clinic, ALA can improve cognitive impairments in patients with Alzheimer’s disease (AD) and other dementias.
Jie Zhang, Yanshuang Jiang, Xiangjun Dong, Zijun Meng, Liangye Ji, Yu Kang, Mingjing Liu, Weihui Zhou, Weihong Song   +8 more
doaj   +1 more source

Genetic and molecular markers of cortical brain biopsy in idiopathic normal pressure Hydrocephalus: A scoping review

Interdisciplinary Neurosurgery
Introduction: Idiopathic normal pressure hydrocephalus (iNPH) is a condition classically defined by the triad of gait disturbance, cognitive dysfunction, and urinary incontinence.
James Kelbert, Rishika Bhojanapalli, Gilberto Perez Rodriguez Garcia, Dana Saleh, Rosa Araujo, Ganesh Murthy, Robert W Bina   +6 more
doaj   +1 more source

Putative long range mossy fiber sprouting and regional cytochrome c oxidase alteration in the hippocampus of patients with mesial temporal lobe epilepsy

Scientific Reports
Mesial temporal lobe epilepsy (MTLE) is known as a distributed network disorder, and regional neuroanatomical changes may significantly contribute to aberrant network formation.
Tian Tu, Lily Wan, Qi-Lei Zhang, Chen Yang, Hong-Shu Zhou, Zhong-Ping Sun, Hong-Yu Long, Bei-Sha Tang, Aihua Pan, Ewen Tu, Jian Wang, Zhi-Quan Yang, Zhen-Yan Li, Xiao-Xin Yan   +13 more
doaj   +1 more source

Inhibition of Notch signaling affects hepatic oval cell response in rat model of 2AAF-PH

Hepatic Medicine: Evidence and Research, 2011
Houda Darwiche, Seh-Hoon Oh, Nicole C Steiger-Luther, Jennifer M Williams, Dana G Pintilie, Thomas D Shupe, Bryon E PetersenDepartment of Pathology, Immunology, and Laboratory Medicine, Program in Stem Cell Biology and Regenerative Medicine, College of ...
Darwiche H, Oh S-H, Steiger-Luther NC, Williams JM, Pintilie DG, Shupe TD, Petersen BE   +6 more
doaj  

Effects of antihypertensive agents on Alzheimer’s disease biomarkers in hypertensive rats with experimentally induced Alzheimer’s

Zanco Journal of Medical Sciences
Background and objective: The most common cause of dementia in the elderly is Alzheimer's disease (AD). Numerous research studies have demonstrated a connection between hypertension (HTN) and the risk of developing AD.
Marwan Qasim Nadir, Rojgar Hamed Ali
doaj   +1 more source

BACE2 tunes lipid uptake through lipid transporters shedding supporting cancer cell proliferation

Journal of Experimental & Clinical Cancer Research
Background Lipids play crucial roles in signal transduction, membrane integrity, and energy metabolism. In cancer, lipid metabolism is frequently dysregulated. Proliferating cancer cells exhibit enhanced lipid uptake, synthesis, and storage; however, the
Vittoria Matafora, Alice Elhagh, Alessandra Morelli, Laura Tronci, Angela Cattaneo, Camilla Conti, Francesca Casagrande, Francesco Farris, Angela Bachi   +8 more
doaj   +1 more source

Regulation of Alpha-Secretase ADAM10 In vitro and In vivo: Genetic, Epigenetic, and Protein-Based Mechanisms. [PDF]

Front Mol Neurosci, 2017
Endres K, Deller T.
europepmc   +1 more source