Results 171 to 180 of about 27,826 (225)

Subtype-Independent Dysregulation of the Notch Signaling Pathway and Its miRNA Regulators in Breast Cancer. [PDF]

Biomedicines
Mitka-Krysiak E, Król-Jatręga K, Ossowski P, Zmarzły N, Bereza K, Ordon P, Kulej W, Sirek T, Sirek A, Boroń K, Boroń M, Boroń D, Grabarek BO.   +12 more
europepmc   +1 more source

Exploring Gene Expression Patterns in Alzheimer's Disease Using a Human Microarray Data Meta-Analysis. [PDF]

Biology (Basel)
Dermitzaki E, Zogopoulos VL, Malatras A, Georgopoulou V, Aslanoglou PM, Teta A, Kalligianni MR, Karoussiotis C, Iconomidou VA, Sotiropoulos I, Michalopoulos I.   +10 more
europepmc   +1 more source

Editorial: Cellular and molecular pathologies of Alzheimer's disease: understanding the link between different etiological factors for therapeutic exploitation. [PDF]

Front Cell Dev Biol
Sabbir MG.
europepmc   +1 more source

The role of Aß-peptide on spatial memory, EEG, auditory evoked potential and nicotinic cholinergic receptors in A/P transgenic mice (Amyloidi ß-peptidin osuus Alzheimerin taudin mallina käytettävien A/P siirtogeenisten hiirten paikkamuistihäiriössä, EEG- ja kuuloherätevastelöydöksissä sekä kolinergisissa nikotiinireseptoreissa tavatuissa muutoksissa) [PDF]

Wang, Jun
core  

The GPCR Connection: Linking Alzheimer's Disease and Glioblastoma. [PDF]

J Cell Mol Med
Caniceiro AB, Agostinho SP, Piochi LF, Rosário-Ferreira N, Moreira IS.   +4 more
europepmc   +1 more source

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Gelatinase A not alpha-secretase?

Nature, 1994
David Allsop
exaly   +3 more sources

A closer look at alpha-secretase.

Current Alzheimer research, 2008
Accumulation of amyloid beta-peptides (Abeta) in the brain is believed to contribute to the development of Alzheimer disease (AD). Abeta, a 40-42 amino acid-comprising proteolytical fragment of the amyloid precursor protein (APP), is released from APP by sequential cleavages via beta- and gamma-secretases.
Bruno, Vincent, Moustapha Alfa, Cisse, Claire, Sunyach, Marie-Victoire, Guillot-Sestier, Frédéric, Checler   +4 more
openaire   +3 more sources

Regulation of alpha-secretase ADAM10 expression and activity

Experimental Brain Research, 2011
The amyloid precursor protein (APP) has a pivotal role in pathogenesis of Alzheimer's disease (AD) via its beta- and gamma-secretase-derived cleavage products--the A-beta peptides. An alternative processing pathway provided by the alpha-secretase prevents formation of those toxic peptides and gives rise to the neurotrophic and neuroprotective cleavage ...
Kristina, Endres, Falk, Fahrenholz
openaire   +2 more sources

Alpha-Secretase As a Therapeutic Target

Current Alzheimer Research, 2007
In the non-amyloidogenic pathway the alpha-secretase cleaves the amyloid precursor protein (APP) within the sequence of Abeta-peptides and precludes their formation. In addition, alpha-secretase cleavage releases an N-terminal extracellular domain with neurotrophic and neuroprotective properties.
openaire   +2 more sources