Results 191 to 200 of about 27,826 (225)
Some of the next articles are maybe not open access.
Regulation of APP cleavage by alpha-, beta- and gamma-secretases.
FEBS letters, 2000Proteolytic cleavage of the amyloid protein from the amyloid protein precursor (APP) by APP secretases is a key event in Alzheimer's disease (AD) pathogenesis. alpha-Secretases cleave APP within the amyloid sequences, whereas beta- and gamma-secretases cleave on the N- and C-terminal ends respectively.
J, Nunan, D H, Small
openaire +1 more source
Furin is an endogenous regulator of α-secretase associated APP processing
Biochemical and Biophysical Research Communications, 2006Constitutive and PKC-regulated alpha-secretase pathways have been reported to produce the secreted form of alpha-secretase-derived APP (sAPPalpha). Here, we examined putative role of furin in the regulation of alpha-secretase activity in vitro and in vivo.
Eun Mi, Hwang +6 more
openaire +2 more sources
Klotho is a substrate for alpha-, beta- and gamma-secretase.
FEBS letters, 2009Klotho is an anti-aging protein with different functions of the full-length membrane protein and the secreted hormone-like form. Using overexpression and knock-down approaches as well as embryonic fibroblasts of knock-out mice we present evidence that Klotho is shedded by the alpha-secretases ADAM10 and 17 as well as by the beta-secretase beta-APP ...
Laura, Bloch +6 more
openaire +1 more source
The Non-Amyloidogenic Pathway: Structure and Function of α-Secretases
2006The amyloid cascade hypothesis is the most accepted explanation for the pathogenesis of Alzheimer's disease (AD). APP is the precursor of the amyloid beta peptide (Abeta), the principal proteinaceous component of amyloid plaques in brains of Alzheimer's disease patients.
Elzbieta, Kojro, Falk, Fahrenholz
openaire +2 more sources
Upregulation of the α‐secretase ADAM10 – risk or reason for hope?
The FEBS Journal, 2010A decade ago, a disintegrin and metalloproteinase 10 (ADAM10) was identified as an α‐secretase and as a key proteinase in the processing of the amyloid precursor protein. Accordingly, the important role that it plays in Alzheimer’s disease was manifested.
Kristina, Endres, Falk, Fahrenholz
openaire +2 more sources
Therapeutic targeting of the alpha-secretase pathway to treat Alzheimer's disease.
Discovery medicine, 2010Alzheimer's disease (AD) is a progressive and degenerative disorder pathophysiologically characterized by the accumulation of beta-amyloid peptides (A-beta) in the brain. A-beta is indicated to be the primary agent in the pathogenesis of AD. A-beta is generated from the amyloid precursor protein (APP) via two proteolytic enzymes, beta- and gamma ...
Can, Zhang, Aleister J, Saunders
openaire +1 more source
[S2‐01‐01]: Alpha‐secretase as a therapeutic target
Alzheimer's & Dementia, 2005Falk Fahrenholz +4 more
openaire +1 more source
SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10.
Cell, 2010A hallmark of Alzheimer's disease (AD) is the accumulation of plaques of Abeta 1-40 and 1-42 peptides, which result from the sequential cleavage of APP by the beta and gamma-secretases. The production of Abeta peptides is avoided by alternate cleavage of APP by the alpha and gamma-secretases.
Gizem, Donmez +3 more
openaire +1 more source
Structural basis of γ-secretase inhibition and modulation by small molecule drugs
Cell, 2021Guanghui Yang, Rui Zhou, Xuefei Guo
exaly